Oxidative stress and role of antioxidant and ω-3 essential fatty acid supplementation in schizophrenia

Mahadik, Sahebarao P.; Evans, Denise; Lal, Harbans

doi:10.1016/s0278-5846(00)00181-0

Cited by 209 publications

(92 citation statements)

References 186 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…There have been a lot of evidences that ROS may play an important role in the pathogenesis of schizophrenia. [11][12][13]26,27 The controversial data reported in the literature show variation for the activities of antioxidant enzymes. Red blood cell SOD activity was found to be increased, 28 unchanged, 12 or decreased 8 and catalase and GSH-Px activities were found to be increased, 12 or unchanged 15 in patients with schizophrenia.…”

Section: Discussionmentioning

confidence: 99%

“…8,9 Many studies reported great evidences that ROS may play an important role in the pathogenesis of schizophrenia. [10][11][12][13][14] Yao et al have previously demonstrated that individual antioxidants, albumin, bilirubin and uric acid, were significantly reduced in plasma of patients with chronic schizophrenia, during on and off haloperidol treatment conditions. 15 Yao et al showed that superoxide dismutase (SOD) activity but not Glutathione peroxidase (GSHPx) and catalase activities in schizophrenia during the drug-free period became significantly higher compared to normal controls.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Total antioxidant response in patients with schizophrenia

Üstündağ¹,

Atmaca

Kirtaş

et al. 2006

Psychiatry Clin Neurosci

View full text Add to dashboard Cite

There is a large amount of convincing data demonstrating that reactive oxygen species (ROS) are involved in initiation and development of many different forms of neuropsychiatric disorders. The levels of oxidants and antioxidants in schizophrenia have been evaluated. However, measurements of total antioxidant response (TAR) were not evaluated up to now. Therefore, the objectives of this study are to investigate plasma TAR levels in schizophrenia subtypes. A total of 76 patients with schizophrenia and 25 healthy volunteers were included in the study. Positive and Negative Syndrome Scale (SANS and SAPS, respectively) were applied to patients. TAR values were determined in the plasma of normal healthy controls and patients with schizophrenia. Plasma TAR levels of each schizophrenia subtype were significantly lower than healthy controls (P < 0.01 for disorganized, residual and undifferentiated subtypes and P < 0.01 for paranoid subtype). When intragroup comparisons were performed, paranoid subtype had higher plasma TAR levels compared to other subtypes (P < 0.01). Accordingly, as a whole group, patients with schizophrenia had lower plasma TAR levels compared to controls. Plasma TAR levels were significantly and negatively correlated with SANS scores, and duration of illness was evaluated but not related to other parameters. Consequently, the present study further emphasizes the growing consideration that free radical damage may have an important etiopathogenetic role on the development of schizophrenia and suggests that decreased plasma total antioxidant levels may be related to the progression of illness.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Total antioxidant response in patients with schizophrenia

Üstündağ¹,

Atmaca

Kirtaş

et al. 2006

Psychiatry Clin Neurosci

View full text Add to dashboard Cite

show abstract

“…Based on these findings and theoretical grounds, new treatment strategies such as using antioxidants and nitric oxide synthase (NOS) inhibitors in treating schizophrenia may be an effective and safe additional approach. Nevertheless, high intake of sufficient vitamin E dietary supplementation is beneficial for scavenging free radicals, and can keep the dynamic balance between oxidation and antioxidation (Mahadik et al, 2001) and thus it may improve outcome and prognosis of schizophrenia. Studies developed by Zhang et al(2001a; indicated that ginkgo biloba adds haloperidol attribute to chronic or resistant schizophrenia.…”

Section: Discussionmentioning

confidence: 99%

Imbalanced free radicals and antioxidant defense systems in schizophrenia: A comparative study

Chen

et al. 2006

J. Zhejiang Univ. - Sci. B

View full text Add to dashboard Cite

Abstract:Objective: To examine changes of blood oxidative-antiovidative level in schizophrenic patients and its relationship with clinical symptoms. Methods: Forty-six Chinese patients met DSM-IV (Diagnostic and Statistical Manual of Mental Disorders-IV) criteria for schizophrenia and fifty age-and sex-matched healthy controls were enrolled in the present study. Baseline psychiatric symptom severity was assessed with brief psychiatric rating scale, positive and negative syndrome scale on the blood draw day. Fresh blood samples were collected to measure levels of nitric oxide and lipid peroxide in plasma as well as activities of superoxide dismutase, catalase and glutathione peroxidase in red blood cells by spectrophotometric assays simultaneously. Results: Comparison of the biochemical parameters indicated that the level of nitric oxide and lipid peroxide increased in patient group, which represented a positive correlation with positive scale scores; while the activities of three critical enzymes decreased and showed a negative linear correlation. Conclusion: This study showed that there are dysregulation of free radical metabolism and poor activities of the antioxidant defense systems in schizophrenic patients. Excess free radicals formation may play a critical role in the etiology of schizophrenia. Using antioxidants might be an effective therapeutic approach to partially alleviate or prevent the symptoms of schizophrenia.

show abstract

“…[5][6][7] Oxidative stress may alter neurotransmission patterns, neuronal function and brain activity in general, and can also disrupt the membrane integrity. 8,9 Both the importance of fatty acid composition in brain cell membranes and the involvement of PUFAs in the development of various psychiatric disorders have been intensively studied.…”

Section: Introductionmentioning

confidence: 99%

Oxidative status and the severity of clinical symptoms in patients with post-traumatic stress disorder

et al. 2014

View full text Add to dashboard Cite

Background: The aim of this study was to measure the parameters of oxidative stress in the blood of patients with post-traumatic stress disorder. Methods: The study included 80 male war veterans who participated actively in the Homeland war in Croatia. Volunteers were divided into two groups: 50 veterans diagnosed with post-traumatic stress disorder and 30 without diagnosis. The self-assessment Hospital Anxiety and Depression Scale and the Beck Depression Inventory were used to detect the severity of depression and anxiety in the post-traumatic stress disorder patients. Catalytic concentrations of superoxide dismutase and glutathione peroxidase in erythrocytes and the concentration of malondialdehyde in serum were measured spectrophotometrically. Results: Although the catalytic concentrations of erythrocyte superoxide dismutase and erythrocyte glutathione peroxidase were within the reference range for both groups, the values obtained for the post-traumatic stress disorder group were significantly lower (P < 0.001). For serum malondialdehyde concentrations, no statistically significant differences between the groups were found. Conclusions: Lower catalytic concentrations of erythrocyte superoxide dismutase and erythrocyte glutathione peroxidase in patients with post-traumatic stress disorder may indicate a weaker response to oxidative stress due to impaired enzyme activity and/or decreased synthesis. Conversely, no significant changes in serum malondialdehyde concentrations suggest a compensated balance and adaptive response to (oxidative) stress.

show abstract

Oxidative stress and role of antioxidant and ω-3 essential fatty acid supplementation in schizophrenia

Cited by 209 publications

References 186 publications

Total antioxidant response in patients with schizophrenia

Total antioxidant response in patients with schizophrenia

Imbalanced free radicals and antioxidant defense systems in schizophrenia: A comparative study

Oxidative status and the severity of clinical symptoms in patients with post-traumatic stress disorder

Contact Info

Product

Resources

About