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citations
Cited by 28 publications
(31 citation statements)
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References 33 publications
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“…It is a critical aspect in human biomonitoring studies associated to physiological state and life style [13]. DNA damage and DNA repair seem to be closely associated with aging as a result of endogenous factors, lifestyle, occupational or environmental exposure [30]. Some atherosclerosisrelated diseases, whose pathogenesis involves both inflammation and oxidative stress, lead to DNA-damage induction [31] and could explain the higher basal DNA damage found in our study in patients and in matched controls [32].…”
Section: Discussionsupporting
confidence: 48%
“…It is a critical aspect in human biomonitoring studies associated to physiological state and life style [13]. DNA damage and DNA repair seem to be closely associated with aging as a result of endogenous factors, lifestyle, occupational or environmental exposure [30]. Some atherosclerosisrelated diseases, whose pathogenesis involves both inflammation and oxidative stress, lead to DNA-damage induction [31] and could explain the higher basal DNA damage found in our study in patients and in matched controls [32].…”
Section: Discussionsupporting
confidence: 48%
“…Exercise can produce an imbalance between ROS and antioxidants, which is referred to as oxidative stress [14]. In the past three decades, several studies have indicated that oxidative stress can result in extensive lipid, protein, and DNA damage, which may lead to cell dysfunction, aging, carcinogenesis, and neurodegenerative and cardiovascular diseases [15]. Accumulated evidence has shown that increased antioxidant enzyme activity, increased resistance to oxidative stress, and lower levels of oxidative damage may protect against oxidative stressrelated damage to tissues and, on a microscopic level, to cellular macromolecules [15,16].…”
Section: Discussionmentioning
confidence: 99%
“…Increased DNA damage can induce the synthesis of a variety of misfolded proteins and therefore impair cellular function [11,15]. 8-hydroxydeoxyguanosine is produced by an enzymatic cleavage following 8-hydroxylation of the guanine base of DNA.…”
Section: Discussionmentioning
confidence: 99%
“…Several molecular and cellular mechanisms are associated with cellular senescence including accumulation of DNA damage, impairment of DNA repair epigenetic modifications in nuclear DNA, protein damage from oxidative stress, and telomere attrition [3,26]. COPD following smoking is a disease-related senescence it causes DNA damage from compounds present in cigarettes that leads to telomere shortening, due to a greater need for repair on airway epithelium, after being injured by toxic substances.…”
Section: Age-related Mechanisms As Probable Causes For Emphysemamentioning
confidence: 99%
“…Reactive oxygen species (ROS) and other free radicals may damage cell membranes, particularly because of the oxidation of lipids, proteins and DNA, which may lead to cell dysfunctions and aging, carcinogenesis, neurodegenerative and cardiovascular diseases. DNA damage and DNA repair seem to be closely associated with aging [3].…”
Section: Introductionmentioning
confidence: 99%