Oxidative stress and DNA damage in Fischer rats following acute exposure to trichloroethylene or perchloroethylene

Toraason, Mark; Clark, John C.; Dankovic, David A.; Mathias, Patty; Skaggs, Steve; Walker, Cynthia V.; Werren, Dwight

doi:10.1016/s0300-483x(99)00083-9

Cited by 68 publications

(46 citation statements)

References 32 publications

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“…We supposed that HHCB increased the rate of damage above background levels and thus enlarged the potential for unrepaired lesions to become permanent mutations. Our hypothesis was supported by an investigation conducted previously on rat liver [19] and on human cells.…”

Section: Discussionsupporting

confidence: 84%

“…Oxidative damage seems to be a major mechanism involved in DNA toxicity induced by organic and inorganic pollutants [19] and our test conducted with HHCB supports this consideration. HHCB was able to produce DNA damages in P. chrysosporium cells probably by some of the products of DNA oxidative damage such as modified bases, primarily 8-oxoguanine, abasic sites, base adducts of carbon-centred radicals and single or double strand breaks in the phospho-sugar back-bone of DNA [20].…”

Section: Discussionsupporting

confidence: 75%

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Cellular and Molecular Damage by Ganaxolide on Phanerochaete Chrysosporium

Xiong¹,

Liu²,

Li³

et al. 2015

IJESD

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Abstract-Galaxolide (1, 3, 4, 6, 7, 8-hexahydro-4, 6, 6, 7, 8, 8-hexamethyl-cyclopenta-γ-2-benzopyran, HHCB) is recognized as a novel contaminant in water and has potential adverse impacts on aquatic organisms. The toxic effect of HHCB on Phanerochaete chrysosporium was investigated by exposure of the fungus in nitrogen-limited culture medium to various concentrations of HHCB. The cultivation results showed that both the size and the quantity of the mycelial pellets of P. chrysosporium could be reduced when the concentration of HHCB was higher than 300 mg/L. DNA damage of P. chrysosporium by HHCB was also detected. Comparing with that in the control, the percent polymorphism under different concentrations of HHCB increased, from 21.4% to 42.9%. In addition, the result of UPGMA (un-weighted pair group method of arithmetic means) dendrogram showed that the Simple Matching Coefficient (SM) was decreased with an increase in the concentrations of HHCB. Thus, as an environmental pollutant, HHCB has the toxic effect on P. chrysosporium at both cellular and molecular level.Index Terms-AFLP, Phanerochaete chrysosporium, HHCB, DNA damaging effects.

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Section: Discussionsupporting

confidence: 84%

Section: Discussionsupporting

confidence: 75%

Cellular and Molecular Damage by Ganaxolide on Phanerochaete Chrysosporium

Xiong¹,

Liu²,

Li³

et al. 2015

IJESD

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“…8-OHdG adduct in DNA has been used most extensively as a biomarker of oxidative stress. 26) As shown in Fig. 2C, STZ treatment increased 13290 pg/ml of 8-OHdG amount compared to 7710 pg/ml in control cells, and KIOM-79 treatment decreased 10650 pg/ml, indicating a protective effect of KIOM-79 on STZ induced DNA damage.…”

Section: Effects Of Kiom-79 On Cellular Dna Damage and Lipid Peroxidamentioning

confidence: 62%

Cytoprotective Effects of KIOM-79 on Streptozotocin Induced Cell Damage by Inhibiting ERK and AP-1

Kang

Lee

Kim

et al. 2007

Biological & Pharmaceutical Bulletin

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“…Furthermore, the levels of 8-OHdG in the postworkshift urines (24.55 ( 5.97 µmol/mol creatinine) were much higher than those in other occupational exposure workers (22,24,47,48,50,(56)(57)(58), even close to the concentrations in cancer patients such as prostate cancer and bladder cancer (Figure 2) (49). Although no tumor or cancer has been found in the workers yet, it is undoubted that there is a high cancer risk originated from the oxidative stress indicated by the elevated urinary 8-OHdG levels in the E-waste dismantling workers exposed to high concentrations of PCDD/Fs, PBDEs, and PCBs.…”

Section: Resultsmentioning

confidence: 85%

Elevated Levels of Urinary 8-Hydroxy-2′-deoxyguanosine in Male Electrical and Electronic Equipment Dismantling Workers Exposed to High Concentrations of Polychlorinated Dibenzo-p-dioxins and Dibenzofurans, Polybrominated Diphenyl Ethers, and Polychlorinated Biphenyls

Wen

Yang

Gong

et al. 2008

Environ. Sci. Technol.

119

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To investigate the occupational exposure levels to polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs), polybrominated diphenyl ethers (PBDEs), and polychlorinated biphenyls (PCBs), indoor dust (n = 3) in workshops and hair samples from male workers (n = 64) were collected at two electrical and electronic equipment waste (E-waste) dismantling factories located in the LQ area in east China in July 11−13, 2006. Pre- and postworkshift urines (64 of each) were also collected from the workers to study oxidative damage to DNA using 8-hydroxy-2′-deoxyguanosine (8-OHdG) as a biomarker. The concentrations of PCDD/Fs, PCDD/F-WHO-TEQs, PBDEs, PCBs and PCB-WHO-TEQs were (50.0 ± 8.1) × 103, 724.1 ± 249.6, (27.5 ± 5.8) × 106, (1.6 ± 0.4) × 109, (26.2 ± 3.0) × 103 pg/g dry weight (dw) in dust, and (2.6 ± 0.6) × 103 , 42.4 ± 9.3, (870.8 ± 205.4) × 103, (1.6 ± 0.2) × 106, 41.5 ± 5.5 pg/g dw in hair, respectively. The homologue and congener profiles in the samples demonstrated that high concentrations of PCDD/Fs, PBDEs, and PCBs were originated from open burning of E-waste. The 8-OHdG levels were detected at 6.40 ± 1.64 µmol/mol creatinine in preworkshift urines. However, the levels significantly increased to 24.55 ± 5.96 µmol/mol creatinine in postworkshift urines (p < 0.05). Then, it is concluded that there is a high cancer risk originated from oxidative stress indicated by the elevated 8-OHdG levels in the E-waste dismantling workers exposed to high concentrations of PCDD/Fs, PBDEs, and PCBs.

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Oxidative stress and DNA damage in Fischer rats following acute exposure to trichloroethylene or perchloroethylene

Cited by 68 publications

References 32 publications

Cellular and Molecular Damage by Ganaxolide on Phanerochaete Chrysosporium

Cellular and Molecular Damage by Ganaxolide on Phanerochaete Chrysosporium

Cytoprotective Effects of KIOM-79 on Streptozotocin Induced Cell Damage by Inhibiting ERK and AP-1

Elevated Levels of Urinary 8-Hydroxy-2′-deoxyguanosine in Male Electrical and Electronic Equipment Dismantling Workers Exposed to High Concentrations of Polychlorinated Dibenzo-p-dioxins and Dibenzofurans, Polybrominated Diphenyl Ethers, and Polychlorinated Biphenyls

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