volume 155, issue 1, P295-304 2009
DOI: 10.1099/mic.0.020727-0
View full text
|
|
Share

Abstract: The response of a cell to integrated stresses was investigated using environmental and/or genetic perturbations that disrupted labile iron homeostasis and increased oxidative stress. The effects of the perturbations were monitored as nutritional requirements, and were traced to specific enzymic targets. A yggX gshA cyaY mutant strain required exogenous thiamine and methionine for growth. The thiamine requirement, which had previously been linked to the Fe-S cluster proteins ThiH and ThiC, was responsive to ox…

expand abstract