Oxidative stress and brain morphology in individuals with depression, anxiety and healthy controls

Velzen, Laura S. van; Wijdeveld, Madelief; Black, Catherine N.; Tol, M.J. van; Wee, Nic J.A. van der; Veltman, Dick J.; Penninx, Brenda W. J. H.; Schmaal, Lianne

doi:10.1016/j.pnpbp.2017.02.017

Cited by 50 publications

(25 citation statements)

References 32 publications

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“…Besides OS occurring as a part of physiological processes that may be more or less related to normal aging, it is important to note that disease states lead to greater production of ROS and subsequent oxidative damage. As such, OS has been involved in the pathology of various chronic disorders of the brain such as AD [28, 29], PD [30], Huntington's disease [25], amyotrophic lateral sclerosis [31], multiple sclerosis [25], and depression [32], as well as in acute damage that occurs in stroke [33] or traumatic brain injury [34].…”

Section: Oxidative Stress and Its Role In Cns Health And Diseasementioning

confidence: 99%

Oxidative Stress and the Microbiota‐Gut‐Brain Axis

Dumitrescu

Popescu-Olaru

Cozma

et al. 2018

Oxidative Medicine and Cellular Longevity

163

123

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The gut-brain axis is increasingly recognized as an important pathway of communication and of physiological regulation, and gut microbiota seems to play a significant role in this mutual relationship. Oxidative stress is one of the most important pathogenic mechanisms for both neurodegenerative diseases, such as Alzheimer's or Parkinson's, and acute conditions, such as stroke or traumatic brain injury. A peculiar microbiota type might increase brain inflammation and reactive oxygen species levels and might favor abnormal aggregation of proteins. Reversely, brain lesions of various etiologies result in alteration of gut properties and microbiota. These recent hypotheses could open a door for new therapeutic approaches in various neurological diseases.

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Section: Oxidative Stress and Its Role In Cns Health And Diseasementioning

confidence: 99%

Oxidative Stress and the Microbiota‐Gut‐Brain Axis

Dumitrescu

Popescu-Olaru

Cozma

et al. 2018

Oxidative Medicine and Cellular Longevity

163

123

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“…In rodents, different types of chronic stress have been shown to induce increased oxidative stress and decreased anti-oxidant defenses [44,45]. The changes in parameters reflecting the oxidative status can be observed in depressed patients [18]. Patients with late-life depression also exhibit increased obvious oxidative stress damage, in particular lipid peroxidation, and decreased anti-oxidative defenses in the brain [46].…”

Section: Effect Of Sb On Lps-induced Enhancement Of Oxido-nitrosativementioning

confidence: 99%

“…The increased proinflammatory cytokine is also observed in brain tissues in depressed patients [13,14]. Mechanistic studies have revealed that the increased proinflammatory cytokine can trigger oxido-nitrosative stress, a pathological event that could be observed in depressed patients, thereby promoting depression onset and/or progression [15][16][17][18][19]. Previous studies have also found that hippocampus and prefrontal cortex are the key regions of the brain, closely associated with mood and behavior regulation [20,21], and more importantly many compounds that are being studied in preclinical trials have been shown to ameliorate depression-like behaviors in rodents via interfering with neuroinflammatory response and oxido-nitrosative stress in the hippocampus and prefrontal cortex [10,11,22].…”

Section: Introductionmentioning

confidence: 99%

Lipopolysaccharide-Induced Depression-Like Behaviors Is Ameliorated by Sodium Butyrate via Inhibiting Neuroinflammation and Oxido-Nitrosative Stress

Qiu

Liu

et al. 2020

Pharmacology

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Depression is a common disease that afflicts one in 6 people. Numerous hypotheses have been raised in the past decades, but the exact mechanism for depression onset remains obscure. Recently, the neuroinflammatory response and oxidative stress are being attracted more and more attention due to their roles in depression pathogenesis. The inhibition of neuroinflammatory response and oxidative stress is now considered a potential strategy for depression prevention and/or therapy. Sodium butyrate (SB) is a sodium form of the endogenous butyrate. It can inhibit proinflammatory responses and oxidative stress in different models of disease. In the present study, we investigated the effect of SB on lipopolysaccharide (LPS)-induced depression-like behaviors, neuroinflammatory response, and oxido-nitrosative stress in the hippocampus and prefrontal cortex in C57BL6/J mice. Our results showed that 10 days of SB pretreatment at the dose of 300 but not 100 mg/kg markedly ameliorated LPS (0.83 mg/kg)-induced depression-like behaviors in the tail suspension test, forced swimming test, and sucrose preference test. Further analysis showed that 10 days of SB pretreatment not only prevented LPS-induced increases in proinflammatory cytokines, such as interleukin (IL)-1β, IL-6, and tumor necrosis factor-α, in the hippocampus and prefrontal cortex but also prevented LPS-induced enhancement of oxido-nitrosative stress. Taken together, these results demonstrate that SB is such an agent that could be used to prevent depression onset and/or progression, and inhibition of neuroinflammatory response and oxido-nitrosative stress may be a potential mechanism for its antidepressant actions.

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“…Plasma markers of oxidative stress (van Velzen et al, 2017), peripheral inflammatory markers in HIV (Fleischman et al, 2018)expression of glucocorticoid inducible genes in MDD (Frodl et al, 2014a) Socioeconomic status and chronic physiological stress (hair cortisol) (Merz et al, 2019).…”

Section: Neurotoxicitymentioning

confidence: 99%

FreeSurfer based segmentation of hippocampal subfields: a review of methods and applications, with a novel quality control procedure for ENIGMA studies and other collaborative efforts

Sämann¹,

Iglesias²,

Gutman³

et al. 2020

Preprint

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Structural hippocampal abnormalities are common in many neurological and psychiatric disorders, and even variation within the normal range is related to cognitive performance and other complex phenotypes such as stress sensitivity. Hippocampal subregions are increasingly studied, as automated algorithms have become available for mapping and volume quantification. In the context of the ENIGMA Consortium, several Disease Working Groups are using the FreeSurfer software to analyze hippocampal subregion (subfield) volumes in patients with major depressive disorder, bipolar disorders, posttraumatic stress disorder, and other conditions, along with data from matched controls. In this overview, we explain the algorithm’s principle, summarize measurement reliability studies, and demonstrate two additional aspects (subfield autocorrelation and volume/reliability correlation) with illustrative data. We then explain the rationale for a standardized hippocampal subfield segmentation quality control (QC) procedure for improved pipeline harmonization. To guide researchers to make optimal use of the algorithm, we discuss how global size and age effects can be modelled, how QC steps can be incorporated and how subfields may be aggregated into composite volumes. This discussion is based on a synopsis of 162 published neuroimaging studies (01/2013–12/2019) that applied the FreeSurfer hippocampal subfield segmentation in a broad range of domains including cognition and healthy aging, brain development and neurodegeneration, affective disorders, schizophrenia, childhood trauma and posttraumatic stress disorder, inflammatory and systemic disease, alcoholism, stress regulation, neurotoxicity, as well as assessments of heritability, effects of candidate genes, genome-wide association studies and epigenetic effects. Lastly, we highlight points where FreeSurfer-based hippocampal subfield studies may be optimized.

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Oxidative stress and brain morphology in individuals with depression, anxiety and healthy controls

Cited by 50 publications

References 32 publications

Oxidative Stress and the Microbiota‐Gut‐Brain Axis

Oxidative Stress and the Microbiota‐Gut‐Brain Axis

Lipopolysaccharide-Induced Depression-Like Behaviors Is Ameliorated by Sodium Butyrate via Inhibiting Neuroinflammation and Oxido-Nitrosative Stress

FreeSurfer based segmentation of hippocampal subfields: a review of methods and applications, with a novel quality control procedure for ENIGMA studies and other collaborative efforts

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