Oxidative potential and water-soluble heavy metals of size-segregated airborne particles in haze and non-haze episodes: Impact of the “Comprehensive Action Plan” in China

Feng, Xiaolei; Shao, Longyi; Jones, Tim; Li, Yaowei; Cao, Yaxin; Zhang, Mengyuan; Ge, Shuoyi; Yang, Cheng‐Xue; Lu, Jing; Bérubé, Kelly Ann

doi:10.1016/j.scitotenv.2021.152774

Cited by 18 publications

(9 citation statements)

References 73 publications

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“…Oxidative stress, induced by coal mine dust, exhibits a time-dependent increase among miners and has the potential to cause DNA damage ( 5 , 30 ). In addition to oxidative stress, DNA damage can also be induced by water-soluble heavy metals including copper, lead, chromium, and cadmium ( 31 , 32 ). Research indicates that DNA damage is a precursor to karyocyte (cell nucleus) apoptosis ( 33 , 34 ).…”

Section: Discussionmentioning

confidence: 99%

Coal mining environment causes adverse effects on workers

Chen,

Ding,

Zhang

et al. 2024

Front. Public Health

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BackgroundThe objective of this study is to study the adverse effects of coal mining environment on workers to discover early effective biomarkers.MethodsThe molecular epidemiological study was conducted with 502 in-service workers, who were divided into miner and auxiliary. We measured the individual levels of dust exposure for participants. Clinical examinations were conducted by qualified doctors. Peripheral blood was collected to measure biochemistry, hemogram, and karyocyte apoptosis.ResultsAll workers were healthy who have not found with any diseases that can be diagnosed medically in the physical examination and showed no difference in dust exposure level, age, height, weight, and body mass index between groups. The working years of miners were lower than that of auxiliaries (p < 0.001). Compared with auxiliaries, the concentration and percentage of lymphocytes (p = 0.040, p = 0.012), basophils (p = 0.027, p = 0.034), and red blood cells (p < 0.001) and the concentration of hemoglobin of miners were lower (p < 0.001). The percentage of neutrophils (p = 0.003), the concentration of mean corpuscular hemoglobin concentration (p = 0.002), and the proportion of karyocyte apoptosis in miners were higher (p < 0.001). Miners presented higher blood urea nitrogen (p < 0.001), ratio of blood urea nitrogen to creatinine (p < 0.001), the high density lipoprotein cholesterol (p < 0.001), lower creatinine (p < 0.05), and cholesterol (p < 0.001).ConclusionThe coal mining environment impacted mining workers’ immune function, renal function, and the hematopoietic system, including BUN/CRE, HGB, RBC, and LYMPH, which could be used as early biomarkers to screen the health of coal miners.

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Section: Discussionmentioning

confidence: 99%

Coal mining environment causes adverse effects on workers

Chen,

Ding,

Zhang

et al. 2024

Front. Public Health

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“…PSA has been proven in a number of studies to accurately reflect the toxicity of PM [ 3 , 36 ]. Therefore, this study was conducted to verify the feasibility of the hemolysis method for PM toxicity detection using the DNA damage rate.…”

Section: Discussionmentioning

confidence: 99%

“…In a pollution episode, as the mass concentration increased, the toxicity index first increased and then decreased ( Figure 3 ), that is, TI (low pollution levels) < TI (heavy pollution levels) < TI (medium pollution levels). Previous studies have shown that there is no correlation between the concentration of PM 2.5 during the sampling period and its unit toxicity [ 36 ]. The toxicity of PM 2.5 is only related to its composition and, furthermore, to the source of PM 2.5 [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

“…The fiber filters were weighed using an electronic balance (Sartorius CP225D, Göttingen, Germany) with an accuracy of 0.01 mg. The formula calculating the mass concentration, as defined by Feng et al (2022), was employed [36]. According to the mass concentration of PM 2.5 , the pollution degree was divided into low (0-74 µg•m −3 ), medium (75-150 µg•m −3 ), and heavy pollution levels (>150 µg•m −3 ; Table 1).…”

Section: Sample Collectionmentioning

confidence: 99%

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Hemolytic Properties of Fine Particulate Matter (PM2.5) in In Vitro Systems

Bai,

Zhang,

Shao

et al. 2024

Toxics

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Epidemiological studies have suggested that inhalation exposure to particulate matter (PM) air pollution, especially fine particles (i.e., PM2.5 (PM with an aerodynamic diameter of 2.5 microns or less)), is causally associated with cardiovascular health risks. To explore the toxicological mechanisms behind the observed adverse health effects, the hemolytic activity of PM2.5 samples collected during different pollution levels in Beijing was evaluated. The results demonstrated that the hemolysis of PM2.5 ranged from 1.98% to 7.75% and demonstrated a clear dose–response relationship. The exposure toxicity index (TI) is proposed to represent the toxicity potential of PM2.5, which is calculated by the hemolysis percentage of erythrocytes (red blood cells, RBC) multiplied by the mass concentration of PM2.5. In a pollution episode, as the mass concentration increases, TI first increases and then decreases, that is, TI (low pollution levels) < TI (heavy pollution levels) < TI (medium pollution levels). In order to verify the feasibility of the hemolysis method for PM toxicity detection, the hemolytic properties of PM2.5 were compared with the plasmid scission assay (PSA). The hemolysis results had a significant positive correlation with the DNA damage percentages, indicating that the hemolysis assay is feasible for the detection of PM2.5 toxicity, thus providing more corroborating information regarding the risk to human cardiovascular health.

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“…Many metals, including arsenic (As), cadmium (Cd), chromium (Cr), and nickel (Ni), are known carcinogens, and can lead to lung, skin, or bladder cancer [ 1 ]. These metals are also ubiquitous in multiple environments, including the atmosphere [ 2 ], water bodies [ 3 ], and soil [ 4 ]. Some non-carcinogenic metal ions, such as copper (Cu) and iron (Fe), can cause oxidative stress and can subsequently induce DNA damage, lipid peroxidation, protein modification, and other effects.…”

Section: Introductionmentioning

confidence: 99%

Toxic Metals in Particulate Matter and Health Risks in an E-Waste Dismantling Park and Its Surrounding Areas: Analysis of Three PM Size Groups

2022

IJERPH

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Heavy metals generated from e-waste have created serious health risks for residents in e-waste disposal areas. This study assessed how airborne toxic metals from an e-waste dismantling park (EP) influenced surrounding residential areas after e-waste control. PM2.5, PM10, and total suspended particles (TSP) were sampled from 20 sites, including an EP, residential areas, and an urban site; ten kinds of metals were analyzed using ICP-MS and classified as PM2.5, PM2.5–10, and PM10–100. Results showed that metals at the EP tended to be in coarser particles, while metals from residential areas tended to be in finer particles. A source analysis showed that metals from the EP and residential areas may have different sources. Workers’ cancer and non-cancer risks were higher when exposed to PM2.5–10 metals, while residents’ risks were higher when exposed to PM2.5 metals. As and Cr were the most strongly associated with cancer risks, while Mn was the most strongly associated with the non-cancer risk. Both workers and residents had cancer risks (>1.0 × 10−6), but risks were lower for residents. Therefore, e-waste control can positively affect public health in this area. This study provides a basis for further controlling heavy metal emissions into the atmosphere by e-waste dismantling and encouraging worldwide standardization of e-waste dismantling.

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Oxidative potential and water-soluble heavy metals of size-segregated airborne particles in haze and non-haze episodes: Impact of the “Comprehensive Action Plan” in China

Cited by 18 publications

References 73 publications

Coal mining environment causes adverse effects on workers

Coal mining environment causes adverse effects on workers

Hemolytic Properties of Fine Particulate Matter (PM2.5) in In Vitro Systems

Toxic Metals in Particulate Matter and Health Risks in an E-Waste Dismantling Park and Its Surrounding Areas: Analysis of Three PM Size Groups

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