1967
DOI: 10.1126/science.155.3767.1288
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Abstract: Mitochondria from the whole brain or cerebellum of newborn guinea pigs with experimental bilirubin encephalopathy failed to exhibit uncoupling of oxidative phosphorylation. The pigment concentrations required to initiate uncoupling in vitro are much higher than those found in the brain of neurotoxic animals.

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Cited by 62 publications
(20 citation statements)
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“…However, animal studies in vivo have failed to consistently establish a primary effect of bilirubin on brain energy metabolism. ATP depletion and impaired respiration have been reported in the cerebella of kernicteric Gunn rats (a), but mitochondria isolated from whole brain and cerebella of newborn guinea pigs made kernicteric with infusions of bilirubin were not uncoupled (9). Another study failed to establish any difference in respiratory control indices of whole brain mitochondria from neonatal kernicteric Gunn rats and their nonjaundiced heterozygous littermates (10).…”
mentioning
confidence: 85%
“…However, animal studies in vivo have failed to consistently establish a primary effect of bilirubin on brain energy metabolism. ATP depletion and impaired respiration have been reported in the cerebella of kernicteric Gunn rats (a), but mitochondria isolated from whole brain and cerebella of newborn guinea pigs made kernicteric with infusions of bilirubin were not uncoupled (9). Another study failed to establish any difference in respiratory control indices of whole brain mitochondria from neonatal kernicteric Gunn rats and their nonjaundiced heterozygous littermates (10).…”
mentioning
confidence: 85%
“…Bilirubin inhibits oxidative phosphorylation in vitro (34,35), but the results of in vivo experiments are contradictory (36,37).…”
Section: R 4 6 Bu-site11mentioning
confidence: 99%
“…Early studies established that mitochondria might be a major target for UCB neurotoxicity, as demonstrated by impairment in mitochondrial function leading to the uncoupling of oxidative phosphorylation (Zetterstrom and Ernster, 1956;Cowger et al, 1965;Diamond and Schmid, 1967;Menken and Weinbach, 1967;Mustafa et al, 1969). Additional effects of UCB in neural tissues and neuronal cell lines include inhibition of DNA and protein synthesis, changes in carbohydrate metabolism, and modulation of neurotransmitter synthesis and release.…”
mentioning
confidence: 99%