2013
DOI: 10.4161/jkst.25764
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Abstract: STAT3 and STAT5 (STAT3/5) proteins are crucial mediators of cytokine- or growth factor-induced cell survival and proliferation. These transcription factors are frequently overactivated in a variety of solid tumors and hematopoietic neoplasms and are targets of various oncogenes with tyrosine kinase activity. STAT3/5 proteins regulate expression of genes involved in survival and proliferation in the nucleus and interact with signaling pathways in the cytoplasm. Evidences for a cross-talk between STAT3/5 and oxi… Show more

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Cited by 45 publications
(45 citation statements)
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References 79 publications
(104 reference statements)
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“…() reported similar findings of decreased XDH activity with inhibition of JAK2 in endothelial cells. The JAK/STAT pathway is also involved in metabolic reprogramming and resistance to therapies in solid tumors (Bourgeais et al ., ; Quintás‐Cardama and Verstovsek, ; Thomas et al ., ; Wang et al ., ; Yu and Jove, ). Our pathway analysis based on gene signatures has shown the involvement of JAK/STAT pathways, metabolic pathways, and oxidative stress, indicating a possible mechanism for the synergism between JAK2 inhibition and XDH inhibition.…”
Section: Resultsmentioning
confidence: 99%
“…Leptin is upregulated in obesity where it is involved in critical steps of cell homeostasis from cell growth (19) to metabolism (20) and energy production (21). A crosslink between ROS production and leptin signalling has been reported in several tissues including endothelium (22) and ovaries (23), and could be one of the signaling pathways activated through the leptin receptor OB-R in the presence of leptin (24). However, there is surprisingly little data on how leptin affects oxidative stress, especially in cancer (25).…”
Section: Introductionmentioning
confidence: 99%
“…Underlying pathologies (malignancy, surgery and immobilization) may have affected the oxidative-antioxidative balance in the secondary DVT group [25,26]. Mean age of the control group was lower than that of the DVT group.…”
Section: Discussionmentioning
confidence: 97%
“…It was previously demonstrated that oxidative stress may inhibit the stimulation of JAK‐STAT signalling by certain cytokines (Kaur et al , ; Di Bona et al , ; reviewed in Bourgeais et al , ). In line with this notion, Gheysarzadeh and Yazdanparast () have shown recently that, under conditions of oxidative stress, the STAT5 ↑/miR‐182↑/FOXO1↓ axis can be altered to rapidly up‐regulate FOXO1 activity (STAT5↓/miR‐182↓/FOXO1↑).…”
Section: Selected Mirnas Regulating Foxo Expression and Their (Patho‐mentioning
confidence: 99%
“…Ames mice have been reported to harbour elevated transcripts of catalase, SOD and GPx in multiple tissues (Brown-Borg et al, 1999) (Brown-Borg & Rakoczy, 2000) which can be suppressed by exogenous GH administration (Brown-Borg & Rakoczy, 2003). In the case of GHR KO however, a lack of free radical scavenging in the liver and kidney has been reported (Hauck et al, 2002 (Bourgeais et al, 2013). …”
Section: Free Radicals and Reactive Oxygen Speciesmentioning
confidence: 99%