Oxidative damage to proteins related to metals and antioxidant defenses in breastmilk

Castillo-Castañeda, Patricia Carolina; Gaxiola-Robles, Ramón; Labrada-Martagón, Vanessa; Vargas, Baudilio Acosta; Méndez-Rodríguez, Lía Celina; Zenteno‐Savín, Tania

doi:10.20960/nh.976

Cited by 15 publications

(6 citation statements)

References 25 publications

(34 reference statements)

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“…Interestingly, even among smokers, antioxidant potential was found to be prevalent among the milk of preterm infants (Orhon et al, 2009; Zagierski et al, 2012). A study using transitional milk (Castillo-Castañeda et al, 2014) correlated the number of pregnancies and the mothers’ age. In this study, a higher lipid peroxidation value was associated with a lower number of pregnancies and a younger age.…”

Section: Discussionmentioning

confidence: 99%

Influence of Maternal Dietary Pattern on the Pro-Oxidant and Antioxidant Status of Mother’s Own Milk

Silva,

Vasconcelos,

Pessoa

et al. 2024

J Hum Lact

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Background: Human milk is essential for a child’s best development. However, what a mother eats while breastfeeding can directly influence the composition of mother’s milk. Research Aim: This study aimed to assess the antioxidant-oxidant profile of human milk and establish a connection between this profile and the dietary habits of the mothers. Methods: A cross-sectional study was conducted at the Hospital Infantil e Maternidade Alzir Bernardino Alves (HIMABA), located in the municipality of Vila Velha-ES, Brazil. The sample included 98 participants. All volunteers completed a structured interview and a Food Frequency Questionnaire. Approximately 5–10 ml of colostrum, transitional milk, and mature milk were manually collected. The antioxidant activity of human milk was assessed using the colorimetric method for free radical scavenging with 2,2’-azinobis-3-ethylbenzothiazoline-6-sulfonic acid. Oxidative stress was determined by measuring lipid peroxidation through malondialdehyde concentration, evaluating advanced oxidation protein products, and assessing total protein content using the Bradford method. Results: The antioxidant profile of colostrum was higher than that observed in later phases of milk, whereas pro-oxidants increased in later phases. Maternal dietary patterns influenced the pro-oxidant status of human milk. Participants with a higher daily intake of milk, dairy products, vegetable oils, olive oils, and legumes exhibited lower levels of lipid peroxidation in colostrum, transition milk, and mature milk, respectively. Conclusions: Our study highlights the vital role of a balanced maternal diet in shaping the pro-oxidant status of human milk, with implications for infant health.

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Section: Discussionmentioning

confidence: 99%

Influence of Maternal Dietary Pattern on the Pro-Oxidant and Antioxidant Status of Mother’s Own Milk

Silva,

Vasconcelos,

Pessoa

et al. 2024

J Hum Lact

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“…In contrast, studies where researchers have tested the effect of zinc, selenium, and copper, as well as vitamin E, to mitigate the effects of PTEs such as Cd, have achieved a considerable increase in endogenous enzyme activity, similar to that reported in this study, in rats supplemented with AM (doses 200 and 400 mg/kg) [ 54 ]. These results can be justified due to the integration of components, such as vitamin C, vitamin E, manganese [ 53 , 62 ], Se, Zn, Cu, and Mg, that confer a good performance in endogenous antioxidant defense [ 24 , 53 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of Arthrospira (Spirulina) maxima on Cadmium-Chloride-Induced Alterations in Sexual Behavior and Fertility in Male Wistar Rats

Candelaria,

Rosa Virginia,

María Angélica

et al. 2024

Pharmaceuticals

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Chronic exposure to potentially toxic elements (PTEs) such as cadmium (Cd) leads to male reproductive toxicity through the generation of oxidative stress. Spirulina Arthrospira maxima (AM) is a cyanobacterium that has been consumed since ancient times for its high nutritional value, and in recent years for its antiviral, hepatoprotective, hypoglycemic, anticancer, and antioxidant effects, among others. This study aimed to evaluate the effects of AM against the damage to reproductive health induced by Cd. A total of 48 10-week-old sexually experienced male Wistar rats were distributed in five groups (n = 8): control; vehicle (tween-water); cadmium chloride (CdCl2) 5 mg/kg; and three doses of AM (100, 200 and 400 mg/kg) + CdCl2 5 mg/kg. All treatments were orally administered once a day for 36 consecutive days. At the end, sexual behavior was evaluated, and semen, testicle, and blood samples were obtained to analyze sperm quality, enzymatic activity, and testosterone levels, respectively. Rats exposed to Cd showed a decrease in sexual behavior, as well as in the quality of reproductive health, and an increase in oxidative stress; while rats exposed simultaneously to AM + Cd showed an improvement in all this parameters. Based on our results, we believe that the mechanism by which AM exerts its effect could be attributed to the presence of phycobiliproteins. These compounds are responsible for exerting an antioxidant effect and chelating effect on elements such as Cd.

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“…The only dependable assumption that could be given is related to the higher metal (Cu, Zn) concentration of milk compared to blood [77]. More specifically, the carbonylation of amino acid side chains constitutes a process that is commonly taking place as a result of the interaction between metals and ROS [78].…”

Section: The Oxidative Status Subverted the State Of Affairsmentioning

confidence: 99%

Effects of Inclusion of Schizochytrium spp. and Forage-to-Concentrate Ratios on Goats’ Milk Quality and Oxidative Status

Mavrommatis

Sotirakoglou

Kamilaris

et al. 2021

Foods

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Although the dietary inclusion level of polyunsaturated fatty acids (PUFA) and the forage: concentrate (F:C) ratio affect milk quality, their interaction has not been broadly studied. To address such gaps and limitations a two-phase trial using twenty-two dairy goats was carried out. During the first phase, both groups (20 HF n = 11; high forage and 20 HG n = 11; high grain) were supplemented with 20 g Schizochytrium spp./goat/day. The 20 HF group consumed a diet with F:C ratio 60:40 and the 20 HG-diet consisted of F:C = 40:60. In the second phase, the supplementation level of Schizochytrium spp. was increased to 40 g/day/goat while the F:C ratio between the two groups were remained identical (40 HF n = 11; high forage and 40 HG n = 11; high grain). Neither the Schizochytrium spp. supplementation levels (20 vs. 40) nor the F:C ratio (60:40 vs. 40:60) affected milk performance. The high microalgae level (40 g) in combination with high grain diet (40 HG) modified the proportions of docosahexaenoic acid (DHA), docosapentaenoic acid (DPA), and conjugated linoleic acid (CLA) and the ω3/ω6 ratio in milk, to a beneficial manner according to human health recommendation guidelines. However, the highest inclusion level of Schizochytrium spp. (40 g) and foremost in combination with the high grain diets (40 HG) induced an oxidative response as observed by the increased protein carbonyls (CP) and malondialdehyde (MDA) levels in milk and blood plasma indicating severe limitations for a long-term, on-farm application. In conclusion, the supplementation with 20 g Schizochytrium spp. and high forage diet (60:40) appears to be an ideal formula to enrich dairy products with essential biomolecules for human health without adversely affect milk oxidative stability.

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Oxidative damage to proteins related to metals and antioxidant defenses in breastmilk

Cited by 15 publications

References 25 publications

Influence of Maternal Dietary Pattern on the Pro-Oxidant and Antioxidant Status of Mother’s Own Milk

Influence of Maternal Dietary Pattern on the Pro-Oxidant and Antioxidant Status of Mother’s Own Milk

Effect of Arthrospira (Spirulina) maxima on Cadmium-Chloride-Induced Alterations in Sexual Behavior and Fertility in Male Wistar Rats

Effects of Inclusion of Schizochytrium spp. and Forage-to-Concentrate Ratios on Goats’ Milk Quality and Oxidative Status

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