Oxidative and antioxidative mechanisms in oral cancer and precancer: A review

Choudhari, Sheetal; Chaudhary, Minal; Gadbail, Amol R.; Sharma, Aparna; Tekade, Satyajit Ashok

doi:10.1016/j.oraloncology.2013.09.011

Cited by 148 publications

(124 citation statements)

References 108 publications

Supporting

Mentioning

115

Contrasting

Unclassified

Order By: Relevance

“…These formed free radicals, ROS and RNS are increasing evidence for interfering in a diversity of normal in vivo controlling structures [1]. Once an excess amount of free radicals is produced, they can reduce endogenous defensive enzymes and consequently generate deleterious cellular effects by oxidizing biomolecules like membrane lipids, cellular proteins, enzymes, DNA and RNA, later ending cellular respiration [42]. Numerous studies have revealed that antioxidants obtained from plant may be beneficial in preventing or slowing the destructive outcome of oxidative stress [43][44][45].…”

Section: Discussionmentioning

confidence: 99%

Analysis of in vitro antioxidant activity of Caryota urens L. leaves: A traditional natural remedy

Mamun¹,

Khanum²,

Begum³

et al. 2016

J Coast Life Med

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Analysis of in vitro antioxidant activity of Caryota urens L. leaves: A traditional natural remedy

Mamun¹,

Khanum²,

Begum³

et al. 2016

J Coast Life Med

View full text Add to dashboard Cite

“…Las ERO son moléculas activas que contienen oxígeno, incluyendo los radicales libres (42), los cuales son moléculas o fragmentos moleculares que contienen un electrón desapareado en la capa de valencia y este es capaz de permanecer independiente (43). ERO como los aniones superóxido, radicales hidroxilos, y el peróxido de hidrógeno pueden cambiar el mecanismo de homeostasis oxido-reducción en los tejidos.…”

Section: La Tspo 18kda Y El Estrés Oxidativounclassified

El cáncer bucal y su relación con la proteína translocadora mitocondrial de 18kda

2017

View full text Add to dashboard Cite

“…Oxidative stress is elevated and antioxidant defenses are often overwhelmed in patients with HNSCC [21,37]. Specifically, generation of ROS has been implicated in HNSCC development in tobacco users Figure 2: Effect of RA on cell growth.…”

Section: Ra Serves As a Potent Antioxidant In Hnsccmentioning

confidence: 99%

“…where elevated oxidative stress increases lipid peroxidation and oxidative DNA damage [37]. ROS can also serve as signaling agents themselves by activating a number of key signaling cascades that are important to tumor development and progression, such as the PI3K-Akt and MAPK pathways.…”

Section: Ra Serves As a Potent Antioxidant In Hnsccmentioning

confidence: 99%

Rosmarinic Acid Inhibits Cell Growth and Migration in Head and Neck Squamous Cell Carcinoma Cell Lines by Attenuating Epidermal Growth Factor Receptor Signaling

Tumur¹,

Guerra²,

Yanni³

et al. 2015

J Cancer Sci Ther

View full text Add to dashboard Cite

Objective: Active components of natural foods are increasingly receiving attention for their chemopreventive and chemotherapeutic potential in a wide variety of cancers. Rosmarinic acid (RA), a phenolic compound in various herbal plants, is well-recognized for its anti-oxidant, anti-inflammatory, anti-proliferative properties in a variety of cell types. In this report, we describe a novel role for RA as an inhibitor of epidermal growth factor (EGF) stimulated signaling in HNSCC and propose a cellular reactive oxygen species (ROS)-mediated mechanism for the observed effects.Methods: Cellular growth, migration and reactive oxygen species (ROS) profiles were examined in RA-treated and untreated HNSCC cell lines (UM-SCC-6 and UM-SCC-10B) using the WST-1 viability assay, established in vitro migration assays, and the CM-H2DCFDA ROS assay, respectively. The influence of RA on EGF-stimulated phosphorylation and its downstream pathways was evaluated using Western-blotting techniques.Results: RA inhibited cell viability, migration and cellular production of ROS in HNSCC cell lines. Furthermore, RA inhibited EGF-induced phosphorylation of the EGFR at tyrosine residues 992 and 845, which led to downregulation of the phosphatidylinositol 3-kinase Akt (PI3K/Akt) and mitogen-activated protein kinase ERK (MAPK/ ERK) pathways.Conclusions: This is the first report describing both growth-and motility-inhibitory roles for RA in HNSCC cells. Additionally, our study is the first to demonstrate that treatment with RA can reduce EGF-induced activation of PI3K/ Akt in tumor cells. The present data suggests that RA holds promise as a chemotherapeutic agent against HNSCC. a novel strategy to down-regulate EGFR signaling using the phenolic compound, rosmarinic acid. RosmarinicActive components of natural foods are increasingly receiving attention for their chemopreventive and chemotherapeutic potential in a wide variety of cancers. One such food component, rosmarinic acid (RA), is a widely distributed phenolic compound in various herbal plants such as rosemary, sweet basil, sage, mint, and perilla (Figure 1) [10,11]. RA is regarded as a daily-consumed safe ingredient, due to its extensive use in the food industry for flavoring, but studies have also elucidated a medicinal role for RA, especially in regard to its anti-oxidant, and anti-inflammatory activities [12,13]. Furthermore, an emerging body of literature has also described the growth inhibitory and anti-invasion properties of RA in colon, skin, breast and ovarian cancers in vitro and/or in vivo [14][15][16][17][18][19], but the mechanisms underlying these effects are poorly understood. A chemopreventive role for RA in HNSCC has been described in 7,12-dimethylbenz (a) anthracene-induced hamster buccal pouch carcinogenesis [20], but a chemotherapeutic role for RA in the treatment of HNSCC has not yet been reported.Given the anti-oxidant properties attributed to RA, it is possible that RA's anti-tumor effects stem from its ability to combat oxidative stress in HNSCC. Oxidative ...

show abstract

Oxidative and antioxidative mechanisms in oral cancer and precancer: A review

Cited by 148 publications

References 108 publications

Analysis of in vitro antioxidant activity of Caryota urens L. leaves: A traditional natural remedy

Analysis of in vitro antioxidant activity of Caryota urens L. leaves: A traditional natural remedy

El cáncer bucal y su relación con la proteína translocadora mitocondrial de 18kda

Rosmarinic Acid Inhibits Cell Growth and Migration in Head and Neck Squamous Cell Carcinoma Cell Lines by Attenuating Epidermal Growth Factor Receptor Signaling

Contact Info

Product

Resources

About