Oxidase‐Like Activity of Polymer‐Coated Cerium Oxide Nanoparticles

Abstract

Anorganisches Enzym? Ceroxidnanopartikel zeigen einzigartige Oxidaseaktivität bei niedrigen pH‐Werten. Diese Redoxkatalysatoren können in Immunassays (ELISA) verwendet werden, wenn sie mit geeigneten Liganden modifiziert sind (siehe Bild; hellblau, gelb: Nanopartikel mit Liganden). Diese Modifizierung ermöglicht sowohl die Bindung als auch die Detektion durch katalytische Oxidation empfindlicher kolorimetrischer Farbstoffe (z. B. TMB).

Structural Effects of Fe3O4 Nanocrystals on Peroxidase‐Like Activity

“…More specifically, the product of the cluster spheres exhibited broader diffraction peaks, and the crystal size was about 15 nm by calculation with the DebyeScherrer formula for its {311} peak. [10] The morphology, dimensions, and structural characteristics of the products were found to depend strongly on the amount of CH 3 ONa and water in the reaction system, characterized by SEM and TEM. When the amount of CH 3 ONa was 40 mmol, the product was dominated by cluster spheres with secondary structure as shown in Figure 2 A; a statistical analysis yielded an average size of 170 nm in diameter.…”

Lanthanide Nanoparticles: From Design toward Bioimaging and Therapy

“…40 Poly(acrylic acid)-coated nanoceria conjugated with folic acid can specifically recognize certain tumor cells with elevated expression of folate receptors ( Figure 68a). As compared to traditional enzyme-linked immunosorbent assay (ELISA), nanoceria-based assays eliminated the use of unstable H 2 O 2 , horseradish peroxidase, and antibodies, which make the assay rather stable.…”

Helical Carbon Nanotubes: Intrinsic Peroxidase Catalytic Activity and Its Application for Biocatalysis and Biosensing

“…[11] Subsequently, sheet-like FeS nanostructures and spherical CeO 2 NPs were also found to display peroxidase-or oxidase-like activity, which could be used in biodetection. [12,13] In comparison with natural enzymes, the nanomaterials family may represent promising candidates for enzyme mimetics, having the advantages of controlled synthesis at low cost, tunable catalytic activities, and a high stability against harsh reaction conditions. [14] Therefore, the synthesis of artificial peroxidases with good catalytic properties and a wide range of practical applications is becoming a significant field.…”