Oxcarbazepine for refractory epilepsy: systematic review of the literature

Saconato, Humberto; Prado, Gilmar Fernandes do; Puga, Maria Eduarda dos Santos; Atallah, Álvaro Nagib

doi:10.1590/s1516-31802009000300008

Cited by 11 publications

(5 citation statements)

References 23 publications

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“…Semiologically, it is classified as partial or generalized 2. The clinical manifestations can occur through sensitive, sensory, psychological, vegetative, and motor signs and symptoms of simple or complex nature depending on the neural system involved in the genesis of the disease 2–4. It has been estimated that 50 million patients around the world suffer from epilepsy 1.…”

Section: Introductionmentioning

confidence: 99%

Efficacy and safety of oxcarbazepine in the treatment of children with epilepsy: a meta-analysis of randomized controlled trials

Geng¹,

Wang²

2017

NDT

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BackgroundTo assess the efficacy and safety of oxcarbazepine (OXC) in the treatment of children with epilepsy.MethodsRandomized controlled trials (RCTs) published in PubMed, Embase, Web of Science, Cochrane Library, Scopus, SinoMed (Chinese BioMedical Literature Service System, China), and Chinese National Knowledge Infrastructure (China) database were systematically reviewed. Eligible studies were those that compared the efficacy and safety of OXC with other antiepileptic drugs in epilepsy. Risk ratio (RR) with 95% confidence intervals (95% CIs) was calculated using fixed-effects or random-effects model.ResultsEleven RCTs with a total of 1,241 patients met the inclusion criteria and were included in this meta-analysis. Compared with other antiepileptic drugs (sodium valproate, levetiracetam, phenytoin, and placebo), OXC was associated with similar seizure-free rate (RR =1.06, 95% CI: 0.94, 1.20; P=0.366) and percentage reduction from baseline in seizure frequency (for ≥75% reduction: RR =1.15, 95% CI: 0.88, 1.49; P=0.310; for 50%–75% reduction: RR =1.12, 95% CI: 0.90, 1.39; P=0.301; for <50% reduction: RR =0.79, 95% CI: 0.56, 1.12; P=0.179). Moreover, patients treated with OXC had a comparable incidence of adverse events compared with those treated with other antiepileptic drugs (RR =1.01, 95% CI: 0.92, 1.11; P=0.760).ConclusionOXC showed similar effects and safety as other antiepileptic drugs in the treatment of children with epilepsy. Further well-conducted, large-scale RCTs are needed to validate these findings.

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Section: Introductionmentioning

confidence: 99%

Efficacy and safety of oxcarbazepine in the treatment of children with epilepsy: a meta-analysis of randomized controlled trials

Geng¹,

Wang²

2017

NDT

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“…In the childhood and adolescence specialty, for example, EBP ranged from anxiety disorder, whether for treatment (18) or assessment (19) , vaccination (24)(25) , safety during nebulization (28) , ICU death (29) , physical exercise measure (33) , nutritional interventions and child growth (70) , prenatal and weight at birth (71) , among others. Another quite diversified example comes from psychiatry/mental health: medication treatments (15,18,20,76,80,89) , physical exercise (16) , cognitive therapy (17) , anxiety assessment instrument (19) , quality of life and food disorders (35) , psychological stress x hypertension (40) , family intervention in schizophrenia (50) etc.…”

Section: Discussionmentioning

confidence: 99%

Práticas baseadas em evidências publicadas no Brasil: identificação e análise de suas vertentes e abordagens metodológicas

Lacerda

Nunes

Batista

et al. 2011

Rev. esc. enferm. USP

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Evidence-based practices published in Brazil: identification and analysis of their types and methodological approaches PRÁTICAS BASEADAS EM EVIDÊNCIAS PUBLICADAS NO BRASIL: IDENTIFICAÇÃO E ANÁLISE DE SUAS VERTENTES E ABORDAGENS METODOLÓGICAS PRÁCTICAS BASADAS EN EVIDENCIAS PUBLICADAS EN BRASIL: IDENTIFICACIÓN Y ANÁLISIS DE SUS VERTIENTES Y APROXIMACIONES METODOLÓGICAS RESUMORevisão integrativa de estudos brasileiros sobre práticas baseadas em evidências (PBE) em saúde, publicados em periódicos ISI/JCR, nos últimos 10 anos. O objetivo foi identificar as especialidades que mais realizaram estes estudos, seus enfoques e abordagens metodológicas. A partir de critérios de inclusão, foram selecionados 144 trabalhos. Os resultados indicam que a maior quantidade de estudos feitos em PBE foram sobre infância e adolescência, infectologia, psiquiatria/saúde mental e cirurgia. Os enfoques predominantes foram prevenção, tratamento/reabilitação, diagnóstico e avaliação. As metodologias mais empregadas foram revisão sistemáti-ca sem ou com metanálise, revisão de protocolos ou síntese de estudos de evidências já disponíveis, e revisão integrativa. Constatase forte expansão multiprofissional da PBE no Brasil, contribuindo para a busca de práticas mais criteriosas pela reunião, reconhecimento e análise crítica dos conhecimentos produzidos. O estudo contribui também para a própria análise dos modos de fazer pesquisa e novas possibilidades de investigação. DESCRITORES ABSTRACTThis is an integrative review of Brazilian studies on evidence-based practices (EBP) in health, published in ISI/JCR journals in the last 10 years. The aim was to identify the specialty areas that most accomplished these studies, their foci and methodological approaches. Based on inclusion criteria, 144 studies were selected. The results indicate that most EBP studies addressed childhood and adolescence, infectious diseases, psychiatrics/mental health and surgery. The predominant foci were prevention, treatment/rehabilitation, diagnosis and assessment. The most used methods were systematic review with or without meta-analysis, protocol review or synthesis of available evidence studies, and integrative review. A strong multiprofessional expansion of EBP is found in Brazil, contributing to the search for more selective practices by collecting, recognizing and critically analyzing the produced knowledge. The study also contributes to the analysis itself of ways to do research and new research possibilities. DESCRIPTORSEvidence-based practice Evidence-based nursing Review Meta-analysis RESUMENRevisión integradora de estudios brasileños sobre prácticas basadas en la evidencia (PBE) en salud, publicados en periódicos ISI/JCR en los últimos 10 años. La finalidad fue identificar las especialidades que más efectuaron esos estudios, sus focos y aproximaciones metodoló-gicas. A partir de criterios de inclusión, fueron elegidos 144 estudios. Los resultados indican que la mayor cantidad de estudios llevados a cabo en EBP trataron de la infancia y adolescencia, enfermedade...

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“…(2009 р.) виявили роль окскарбазепіну в лікуванні фармакорезистентних форм епіле псії [88]. У публікаціях J.A.…”

Section: клінічне обстеженняunclassified

Modern approach to diagnosis and treatment of seizures in newborns and early age children

Martyniuk¹,

Znamenska²,

Shveikina³

et al. 2021

MPU

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The article is devoted to the topical problem of neonatology and pediatric neurology — the diagnosis and treatment of seizures in newborns and young children. The work presents an algorithm for the diagnosis and treatment of epileptic seizures in children. It is indicated that the therapeutic effect of most antiepileptic drugs consists of modulation of voltage-gated and ligand-gated channels of membranes of neurons of the cerebral cortex, enhancement of inhibitory synaptic transmission or inhibition of activating synaptic transmission. The issues of the pharmacokinetics and pharmacodynamics of antiepileptic drugs are considered, taking into account the age characteristics of the child's body, in particular, newborns and early age children. The problems of drug interaction were discussed. The properties of individual antiepileptic drugs, which are used in newborns and young children, are considered. Emphasized are «polar» differences in the work of phenobarbital, which depend on the stage of epileptogenesis, namely: suppression of epileptiform activity at the early stage of epileptogenesis and its enhancement in the already formed epileptic focus (epileptic system). The literature data on the differentiated treatment of certain epileptic syndromes are presented. The issues on the prospects for the treatment of genetically determined diseases, which are accompanied by seizures associated with metabolic disorders, are considered. The modern high-tech methods of treatment of these diseases are noted. The role of diet therapy, co-factor therapy in the treatment of hereditary metabolic disorders, in particular, the ketogenic diet as a method of alternative treatment for drug-resistant epilepsy in children, is shown. No conflict of interest was declared by the authors. Key words: newborn, epilepsy, epileptic encephalopathy, treatment, antiepileptic drugs, review.

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Oxcarbazepine for refractory epilepsy: systematic review of the literature

Cited by 11 publications

References 23 publications

Efficacy and safety of oxcarbazepine in the treatment of children with epilepsy: a meta-analysis of randomized controlled trials

Efficacy and safety of oxcarbazepine in the treatment of children with epilepsy: a meta-analysis of randomized controlled trials

Práticas baseadas em evidências publicadas no Brasil: identificação e análise de suas vertentes e abordagens metodológicas

Modern approach to diagnosis and treatment of seizures in newborns and early age children

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