Oxacillin-Induced Tissue Necrosis

Fromm, Laurie; Graham, Diane L

doi:10.1345/aph.18387

Cited by 6 publications

(2 citation statements)

References 15 publications

(14 reference statements)

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“…[10][11][12][13][14][15][16][17][18][19] These 3 methods for diluting intravenous medications are (1) increasing the amount of diluting solution in the administration container (while the amount of medication remains unchanged) prior to administration, (2) slowing the rate of administration of the medication into the blood vessel, and (3) infusing the medication into a vein with a larger volume of blood flow.…”

Section: The Impact Of Dilution On Intravenous Therapymentioning

confidence: 99%

The Impact of Dilution on Intravenous Therapy

LaRue¹,

Peterson²

2011

Journal of Infusion Nursing

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Chemically induced phlebitis continues to be an adverse reaction from the intravenous administration of infusates. The primary method used for decreasing the incidence of chemically induced phlebitis is to dilute infusates to the point where they do not cause tissue damage. The exact amount of dilution required for preventing chemically induced phlebitis is not currently known. This article describes methods for accurately determining the onset of chemically induced phlebitis and for describing the final concentration levels of infusates. Use of the tools presented could help intravenous therapy specialists refine research and, as a result, predict and possibly avoid chemically induced phlebitis.

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Section: The Impact Of Dilution On Intravenous Therapymentioning

confidence: 99%

The Impact of Dilution on Intravenous Therapy

LaRue¹,

Peterson²

2011

Journal of Infusion Nursing

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“…Die ⊡ Tabelle 3 gibt eine Übersicht über häufig in der Anästhesie und Intensivmedizin verwendete Substanzen, deren Paravasat bekannt dafür ist, gewebetoxisch zu sein [14].…”

Section: Abb 4 ▲ Schematischer Aufbau Eines 3-lumenkathetersunclassified

Extravasation?eine seltene Komplikation zentralven�ser Katheter?

Schummer

Müller³

et al. 2003

Der Anaesthesist

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Extravasation is the non-intentional leakage of substances/solutions into the perivascular or subcutaneous space that can result in significant tissue damage. The extent of destruction depends on the properties of the substance, its concentration, and the amount applied. Substances known to cause severe tissue damage include certain chemotherapeutic agents, vasoactive substances, concentrated electrolytes, and other hyperosmolar solutions. Extravasation can be avoided by meticulous monitoring of venous access. When extravasation occurs, the infusion should be stopped immediately. Substances known to cause tissue damage should be removed from perivascular or subcutaneous space within 24 hours by local incision and irrigation. A delay in early treatment may necessitate more extensive surgical debridement and skin coverage operations. Since the extent of deep soft tissue damage is difficult to predict and is often underestimated, a magnetic resonance imaging should be performed before surgery. We report here on a 73-year-old patient, in whom extravasation of potassium-chloride from a dislocated multi-lumen central venous catheter led to a life-threatening skin and soft-tissue necrosis of the neck. This article provides an overview of common vesicants, theories of tissue destruction, potential risk factors, guidelines for prevention, and current treatment strategies.

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Antiinfektiva

Leemhuis¹

2011

Pharmakotherapie in Der Anästhesie Und Intensivmedizin

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Oxacillin-Induced Tissue Necrosis

Abstract: The potential exists for oxacillin 50 mg/mL to cause tissue damage in humans if an extravasation occurs. This reaction may be avoided with use of a less-concentrated preparation, avoidance of infusion pump administration, and identification of high-risk patients.

Cited by 6 publications

References 15 publications

The Impact of Dilution on Intravenous Therapy

The Impact of Dilution on Intravenous Therapy

Extravasation?eine seltene Komplikation zentralven�ser Katheter?

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