Ovulatory response to GnRH agonist during early and late fall in mares

Spencer, Kianna M.; Podico, Giorgia; Megahed, Ameer; Jones, Kristi L.; Bittar, J. H. J.; Canisso, Igor F.

doi:10.1016/j.theriogenology.2022.03.003

Cited by 4 publications

(1 citation statement)

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“…Sucrose acetate isobutyrate (SAIB) is a highly viscous and hydrophobic biodegradable sugar. It has been used as a matrix for the sustained release of drugs such as deslorelin acetate and bupivacaine ( 16 , 17 ). Mixing a small quantity of solvent (ethanol or N-methyl pyrrolidone) with SAIB reduces its viscosity by several fold, making it suitable for injection ( 18 ).…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetics and efficacy of a novel long-acting bupivacaine formulation for cornual nerve block in calves

et al. 2022

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Local anesthetics are commonly used in farm animals to provide analgesia for painful procedures but can cause adverse effects at high systemic concentrations. The pharmacokinetics and efficacy of a long-acting sucrose acetate isobutyrate (SAIB) bupivacaine formulation following cornual nerve block in calves were compared to lidocaine. Fourteen calves were randomly assigned to one of the treatment groups (i) 5% Bupivacaine-SAIB (BUP-SAIB), n = 7; or (ii) 2% lidocaine (LID), n = 7. Cornual nerve block was performed, and duration of effective analgesia was evaluated by nociceptive threshold testing using a hand-held pressure algometer. Blood samples were collected at various time points and plasma concentrations were analyzed by HPLC. Pharmacokinetic parameters were calculated using a non-compartmental model. The mechanical nociceptive thresholds showed that the novel formulation could desensitize the skin around the horn bud for 18.77 ± 8.88 h (range 8–36 h), compared to 0.79 ± 0.34 h (range 0.5–1.5 h) with lidocaine. The mean maximum plasma concentration (Cmax) of bupivacaine was 152.03 (SD 37.34) ng/mL and its Tmax was 0.39 (SD 0.13) h. The half-life of elimination was 32.79 ± 11.00 h and the rate of clearance was 0.12 ± 0.03 L h−1. No toxicity signs were seen after treatment in either group. The novel formulation produced long-lasting analgesia of several times greater duration than that produced by lidocaine. This study showed that the safety and efficacy of the SAIB formulation justifies further studies in a larger population of animals.

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Section: Introductionmentioning

confidence: 99%