2019
DOI: 10.25259/jcis_45_2019
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: Disorder of sex development is an inclusive term that refers to any problem where the genital organ is atypical in relation to chromosomes or gonads. Ovotesticular disorder of sex development, which is formerly known as “true hermaphroditism,” is the most rare form among all disorders of sex development in humans. It is characterized by the simultaneous presence of both ovarian and testicular tissues in the same individual and characteristically presents with ambiguous genitalia in neonates or infants. Herein,… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

0
15
0

Year Published

2020
2020
2024
2024

Publication Types

Select...
8

Relationship

0
8

Authors

Journals

citations
Cited by 13 publications
(15 citation statements)
references
References 8 publications
0
15
0
Order By: Relevance
“…DSD is a congenital genetic disease that is not fully understood. DSD occurs in approximately 0.18% of the human population [38] and 0.75-20% of the porcine population [39]. Previous studies have focused on the genetic mechanism of DSD.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…DSD is a congenital genetic disease that is not fully understood. DSD occurs in approximately 0.18% of the human population [38] and 0.75-20% of the porcine population [39]. Previous studies have focused on the genetic mechanism of DSD.…”
Section: Discussionmentioning
confidence: 99%
“…In domestic animals, DSD decline the product quality, leading to serious economic losses to farmers. Pig intersex is part of animal DSD, called 38, XX disorder of sex development (38,. Typical features of this condition, including 38, XX karyotype, the intersex phenotype of genitalia, and the undeveloped testes or ovotestis.…”
Section: Introductionmentioning
confidence: 99%
“…A change in the external environment like exposure to androgens or maternal tumors can act on the bipotential gonad and cause the reversal of phenotypic sex or mosaicism leading to ambiguous development of genitalia where the hormonal factors induce variability in the phenotype of cells with similar chromosomal sex (Witchel, 2018). Ovotesticular disorder, one of the rare cases of DSD, can occur in sry-negative XX males (Ozdemir et al, 2019). The bipotential gonad develops into both, genetically identical ovarian follicles and seminiferous tubules.…”
Section: Non-genetic Cellular Variability Within a Specialized Organ mentioning
confidence: 99%
“…The ovotesticular syndrome was previously known as true hermaphroditism. (17) There is a hypothesis of an alteration in the signaling pathways involved in gonadal development as the cause for DSD, (3) but the etiology of gonadal dysgenesis and ovotesticular syndrome in most cases is unknown. (18) Regarding XY gonadal dysgenesis, two types have been described: Complete (or pure), and partial.…”
Section: Introductionmentioning
confidence: 99%