Overweight and Obesity in Pediatric Secondary Pseudotumor Cerebri Syndrome

Paley, Grace; Sheldon, Claire A.; Burrows, Evanette; Chilutti, Marianne; Liu, Grant T.; McCormack, Shana E.

doi:10.1016/j.ajo.2014.11.003

Cited by 43 publications

(39 citation statements)

References 33 publications

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“…; Paley et al. ). Nandi and Biswas described one 7‐year‐old boy with bilateral isolated sixth nerve palsy and EBV mononucleosis without any sign of encephalitis (Nandi & Biswas ).…”

Section: Discussionmentioning

confidence: 99%

Ophthalmological findings in children with encephalitis

Hellgren

Fowler

Rydberg

et al. 2016

Acta Ophthalmologica

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ABSTRACT.Purpose: To evaluate ophthalmological abnormalities in children with acute encephalitis. Methods: Thirty-six children included in a hospital-based prospectively and consecutively collected cohort of children with acute encephalitis were investigated for ophthalmological abnormalities. The investigation included clinical ophthalmological examination, fundus photography, neuro-ophthalmological examinations as well as visual and stereo acuity. Results on laboratory examinations, clinical findings, neuroimaging and electroencephalography registrations were recorded for all children. Results: The median age was 4.0 years (Interquartile Range 1.9-9.8). The aetiology was identified in 74% of cases. Three of 36 patients were found to have abnormal ophthalmological findings related to the encephalitis. Transient sixth nerve palsy was seen in a 15-year-old child and transient visual impairment was seen in a 3.5-year-old child. Bilateral miosis and ptosis, i.e. autonomic nerve system symptoms, were seen in an 11-month-old child, with herpes simplex 1 and N-methyl-D-aspartate receptor antibody encephalitis. All three children recovered and improved their ophthalmological function with time. Conclusion: Only 3 of 36 children were found to have ophthalmological abnormalities due to encephalitis and they all improved with time. Thus, ophthalmological consultation does not seem to fit in a screening programme for childhood encephalitis but should be considered in selected cases.

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“…; Paley et al. ). Nandi and Biswas described one 7‐year‐old boy with bilateral isolated sixth nerve palsy and EBV mononucleosis without any sign of encephalitis (Nandi & Biswas ).…”

Section: Discussionmentioning

confidence: 99%

Ophthalmological findings in children with encephalitis

Hellgren

Fowler

Rydberg

et al. 2016

Acta Ophthalmologica

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“…With increasing obesity in the world, the incidence of PTCS is also increasing. Before puberty, the female/male ratio is equal and secondary PTCS is commonly seen (6,7). When seen in males, secondary causes should be well researched (1).…”

Section: Discussionmentioning

confidence: 99%

Clinical and Demographic Features of Pseudotumor Cerebri Syndrome Diagnosed in a University Hospital

Arslan¹,

Arıkanoğlu²,

Akıl³

2017

tnd

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Objective: Pseudotumor cerebri syndrome (PTCS) is characterized by symptoms and signs of increased intracranial pressure without ventriculomegaly, intracranial tumor or mass. This study aimed to explore and analyze 34 patients with PTCS according to age, sex, symptoms of the disorder, cranial magnetic resonance images findings, etiology, and treatment. Materials and Methods:A total of 34 patients who were diagnosed as having PTCS and followed up between January 2011 and August 2016 by Dicle University Medical School Neurology Department were included in this study. PTCS was diagnosed in accordance with the modified Dandy criteria. Results:Thirty-four patients were identified as having PTCS. Twenty-one (91.2%) had headache, 19 (55.9%) had blurred vision, 6 (17.6%) had diplopia, 2 (5.9%) had vertigo, 1 (2.9%) had tinnitus, and 1 (2.9%) had numbness of the face. Twenty-seven patients were diagnosed as having idiopathic intracranial hypertension, 21 (61.8%) had no etiologic factors. Six (17.6%) patients were obese, one of whom had recently gained weight and another had polycystic ovary syndrome. Seven patients were thought to have secondary PTCS with the following etiologic factors: 2 (5.9%) patients had Hashimoto's thyroiditis, 1 (2.9%) had a history of all-trans retinoic acid intake due to a malignancy, 1 (2.9%) had choroid plexus granuloma, 2 (5.9%) had sinus venous thrombosis, and 1 (2.9%) had Familial Meditteranian Fever.Conclusion: Although PTCS was described many years ago, its physiopathology and exact treatment procedures are not clearly understood. The most important target of its treatment is to prevent loss of vision and improve symptoms. With a better understanding of its pathophysiology, effective treatment protocols will be developed. Keywords: Idiopathic intracranial hypertension, pseudotumor cerebri syndrome, headacheAmaç: Psödotümör serebri sendromu (PTSS) ventrikülomegali, intrakraniyal tümör veya kitle olmaksızın intrakraniyal basıncın (İKB) arttığı bir sendromdur. Bu çalışmada kliniğimizde PTSS tanısı ile takip edilen 34 hastanın yaş, cinsiyet dağılımı, semptomları, kraniyal manyetik rezonans görüntüleme bulguları, etiyolojileri ve tedavileri tartışılmaktadır. Gereç ve Bulgular:Olguların 31'inde (%91,2) baş ağrısı, 19'unda (%55,9) bulanık görme, 6'sında (%17,6) diplopi, 1'inde (%2,9) tinnitus, 1'inde (%2,9) yüzde uyuşma, 2'sinde (%5,9) vertigo yakınması vardı. Yirmi yedi hasta idiyopatik intrakraniyal hipertansiyon (İİH) olarak kabul edildi. Yirmi bir hastada (%61,8) etiyoloji saptanamadı. Altı hastada (%17,6) obezite, bunların 1 tanesinde yakın zamanda kilo alma öyküsü, 1 tanesinde de polikistik over sendromu saptandı. Yedi hastada sekonder PTSS düşünüldü. Sekonder sebepler olarak; 2 hastada (%5,9) Hashimoto tiroiditi, 1 hastada (%2,9), malignite nedeniyle all-trans retinoik asit kullanımı, 1 hastada (%2,9) koroid pleksus granülomu, 2 hastada (%5,9) sinüs trombozu, 1 hastada (%2,9) Ailesel Akdeniz Ateşi etiyolojik neden olarak saptandı. Clinical and Demographic Features of Pseudotumor

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“…1 There are conflicting studies explaining the anthropometrics of secondary pediatric PTCS. In one study of children with secondary PTCS, the children were obese 28 ; however, previous studies showed that the majority of children with minocyclineassociated secondary PTCS, 29 with exposure to recombinant growth hormone 30,31 or aldosteronism, 32 were not obese at presentation.…”

Section: Prepubertal Versus Postpubertal Childrenmentioning

confidence: 91%

Update in Pediatric Pseudotumor Cerebri Syndrome

Beres

2020

Semin Neurol

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Pseudotumor cerebri syndrome (PTCS) is a rare condition in children presenting with headache and papilledema from increased intracranial pressure that can cause significant morbidity. This can be idiopathic, also known as idiopathic intracranial hypertension or primary intracranial hypertension, or can be secondary to medications and associated medical conditions. Given the threat to vision, early detection and treatment is needed in all age groups. However, identifying papilledema or pseudopapilledema in children presents unique challenges sometimes as a result of differences between prepubertal and postpubertal children, further elucidating the complex pathophysiology. Management requires brain imaging, lumbar puncture, and frequent eye exams with medical and rarely surgical treatment. Visual outcomes in children are favorable if caught early and management can be prolonged over years. Pediatric PTCS is different from adult PTCS in many ways, and this review will focus on the most updated definitions of the disease, theories of pathophysiology, management, and treatment in the pediatric population.

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Overweight and Obesity in Pediatric Secondary Pseudotumor Cerebri Syndrome

Cited by 43 publications

References 33 publications

Ophthalmological findings in children with encephalitis

Ophthalmological findings in children with encephalitis

Clinical and Demographic Features of Pseudotumor Cerebri Syndrome Diagnosed in a University Hospital

Update in Pediatric Pseudotumor Cerebri Syndrome

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