Overview of the Haematological Effects of COVID-19 Infection

Wiggill, Tracey; Mayne, Elizabeth; Vaughan, Jenifer; Louw, Susan

doi:10.1007/978-3-030-59261-5_14

Cited by 7 publications

(19 citation statements)

References 85 publications

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“…22,27 In early SARS-CoV2 infection, platelet counts have not correlated with the outcome which probably explains the normal platelet count in this cohort. 5,9,36 Anemia could develop during the course of COVID-19 either due to direct SARS-CoV-2 infection, iatrogenic blood loss during admission, or dysregulation of iron metabolism. 5,7 Unlike other studies, Hb level, RDW and MCHC were not associated with worse outcome in our cohort.…”

Section: Discussionmentioning

confidence: 99%

“…[4][5][6] The correlation between early changes in hematological parameters and disease outcome, is under active investigation. 4,5,[7][8][9] Hematological changes reported include changes in full blood count (FBC) parameters, abnormal morphological characteristics of blood cells on peripheral blood smear examination and derangement of hemostatic parameters, referred to as COVID-19-associated coagulopathy (CAC). 4,7,10 FBC findings associated with SARS-CoV-2 infection include anemia, neutrophilia, lymphopenia, monocytosis, eosinopenia, mild thrombocytopenia, and less frequently thrombocytosis.…”

Section: Introductionmentioning

confidence: 99%

“…The burden of the human immunodeficiency virus (HIV) and tuberculosis (TB) infections, compounded by the high prevalence of noncommunicable diseases, increase the difficulty in extrapolating data from other COVID‐19 ravaged countries, to the South African situation. Widely available routine basic laboratory parameters, accessible in low resource settings could facilitate prediction of disease severity and outcome in COVID‐19 5,9,18 . This study aimed to assess the hematological parameters in early COVID‐19 and their correlation with outcome in a resource‐constrained setting.…”

Section: Introductionmentioning

confidence: 99%

“…[1][2][3][4][5] Coronavirus disease 2019 (COVID-19) is associated with multisystem complications and hematological abnormalities of variable severity. [4][5][6] The correlation between early changes in hematological parameters and disease outcome, is under active investigation. 4,5,[7][8][9] Hematological changes reported include changes in full blood count (FBC) parameters, abnormal morphological characteristics of blood cells on peripheral blood smear examination and derangement of hemostatic parameters, referred to as COVID-19-associated coagulopathy (CAC).…”

Section: Introductionmentioning

confidence: 99%

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Hematological findings in adult patients with SARS CoV‐2 infection at Tygerberg Hospital Cape Town South Africa

Abdullah

Cornelissen

Musekwa

et al. 2022

Health Science Reports

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Background: Coronavirus disease 2019 (COVID-19) is associated with hematological abnormalities of variable severity. The full blood count (FBC) and leukocyte differential count (DIFF) could facilitate the prediction of disease severity and outcome in COVID-19. This study aimed to assess the hematological parameters in early severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and their correlation with disease outcome. Methods: A retrospective cross-sectional descriptive study was performed. Adults with a FBC and positive SARS-CoV-2 polymerase chain reaction results between March 1, and June 31, 2020 were reviewed. Basic hematological parameters (FBC, DIFF) and human immunodeficiency virus (HIV) status were recorded. Outcome measures were admission to a general ward or intensive care unit (ICU), recovery or death.Results: Six hundred and eighty-five cases median age 51 years, were analyzed.Forty-four percent were males and fourteen percent were HIV-positive with no association between death and/or ICU admission (p = 0.522 and p = 0.830, respectively). Leucocytosis was predictive of ICU admission (odds ratio [OR]: 2.4, confidence interval [CI]: 1.77-3.8186) and neutrophilia, of both mortality (OR: 1.5, CI: 1.0440-2.0899) and ICU admission (OR: 4, CI: 2.5933-6.475). Median lymphocyte count was decreased and D-dimer raised, showing no significant association with outcome. Raised neutrophil-to-lymphocyte-ratio (NLR) was associated with increased odds of mortality (OR: 2.5, CI: 1.3556-3.2503) and ICU admission (OR: 4.8, CI: 2.4307-9.5430) as was monocyte-to-lymphocyte-ratio (MLR) (OR: 2, CI: 1.3132-2.9064) and (OR: 2.3, CI: 1.0608-1.9935), respectively. Hospital admission and older age were significantly associated with mortality (p = 0.0008 and p < 0.0001), respectively.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Hematological findings in adult patients with SARS CoV‐2 infection at Tygerberg Hospital Cape Town South Africa

Abdullah

Cornelissen

Musekwa

et al. 2022

Health Science Reports

View full text Add to dashboard Cite

show abstract

“…According to the published data, it is stated that COVID-19 not only affects the lungs but also various other systems. Circulatory, haematological, and immune systems are three of them [1][2][3].…”

Section: Introductionmentioning

confidence: 99%