Overview of the Biological Activity of Anthraquinons and Flavanoids of the Plant Rumex Species

Berillo, Dmitriy; Kozhahmetova, Marzhan; Lebedeva, L.P.

doi:10.3390/molecules27041204

Cited by 13 publications

(10 citation statements)

References 106 publications

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“…The content of phloroglucinol derivatives in eucalyptus leaf residue accounted for 1.93% of the raw material. Research has shown that phloroglucinol derivatives have good biological activities such as antibacterial, antiviral, and anti-tumor effects, with broad prospects for medical research, and are expected to become new anti-tumor and antibacterial drugs [ 22 ].…”

Section: Resultsmentioning

confidence: 99%

Preliminary Study on Total Component Analysis and In Vitro Antitumor Activity of Eucalyptus Leaf Residues

Wu,

Wang,

Cheng

et al. 2024

Molecules

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Eucalyptus globulus is widely introduced and cultivated in Yunnan province. Its foliage is mainly used to extract eucalyptus oil, but the by-product eucalyptus residue has not been fully utilized. Based on the above reasons, in this study, we sought to explore the comprehensive utilization potential of eucalyptus resources. The total composition of eucalyptus residue was analyzed by ultra performance liquid chromatography-time-of-flight mass spectrometry (UPLC-Q/TOF MS), and the active components and nutrient components of eucalyptus leaf residue were determined by chemical methods and liquid phase techniques. Meanwhile, the antitumor activity of triterpenoids in eucalyptus leaves was evaluated by tetramethylazazole blue colorimetric assay (MTT). The results of qualitative analysis indicated that 55 compounds were identified from eucalyptus residue, including 28 phloroglucinols, 17 terpenoids, 3 flavonoids, 5 fatty acids, 1 amino acid and 2 polyphenols. Among them, the pentacyclic triterpenoids, in eucalyptus residue, were mainly oleanane type and urthane type. The results of quantitative determination indicated that the content of triterpenoid compounds was 2.84% in eucalyptus residue, which could be enhanced to 82% by silicone separation. The antitumor activity results showed that triterpenoid compounds have moderate inhibitory effects on human breast cancer cell MDA-MB-231, gastric adenocarcinoma cell SGC-7901 and cervical cancer cell Hela. The half maximal inhibitory concentration (IC50) was 50.67, 43.12 and 42.65 μg/mL, respectively. In this study, the triterpenoids from eucalyptus leaf residues were analyzed to reveal that the triterpenoids from eucalyptus leaf have antitumor effects and have potential to be developed as antitumor drugs.

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Section: Resultsmentioning

confidence: 99%

Preliminary Study on Total Component Analysis and In Vitro Antitumor Activity of Eucalyptus Leaf Residues

Wu,

Wang,

Cheng

et al. 2024

Molecules

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“…Perception of nitrogen deficiency and generation of the nitrogen starvation signal are accompanied by attraction of rhizobia to the plant root. This step, in turn, relies on the synthesis and excretion of flavonoids, which act as the signaling molecules secreted by root cells [25,26] (Figure 2). These polyphenols probably belong to the group of chemoattractants for rhizobia, which also include amino acids-e.g., glutamate, proline, arginine, phenylalanine, tryptophan [27,28], and carboxylates, like citrate, malate, and succinate [29,30].…”

Section: Mutual Recognition: Flavonoids As the Attractants For Rhizobiamentioning

confidence: 99%

Signaling in Legume–Rhizobia Symbiosis

Shumilina,

Soboleva,

Abakumov

et al. 2023

IJMS

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Legumes represent an important source of food protein for human nutrition and animal feed. Therefore, sustainable production of legume crops is an issue of global importance. It is well-known that legume-rhizobia symbiosis allows an increase in the productivity and resilience of legume crops. The efficiency of this mutualistic association strongly depends on precise regulation of the complex interactions between plant and rhizobia. Their molecular dialogue represents a complex multi-staged process, each step of which is critically important for the overall success of the symbiosis. In particular, understanding the details of the molecular mechanisms behind the nodule formation and functioning might give access to new legume cultivars with improved crop productivity. Therefore, here we provide a comprehensive literature overview on the dynamics of the signaling network underlying the development of the legume-rhizobia symbiosis. Thereby, we pay special attention to the new findings in the field, as well as the principal directions of the current and prospective research. For this, here we comprehensively address the principal signaling events involved in the nodule inception, development, functioning, and senescence.

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“…fruit extracts and its oil [ 95 ], extracts of Thymus serpyllum L. [ 96 ], extracts of Rumex confertus Willd. leaves [ 97 ], mulberry root bark extracts [ 98 ], Pleurotus ostreatus (Fr.) [ 99 ], castor bean leaf extracts [ 100 ].…”

Section: Anti-neurodegenerative Properties Of Medicinal Plants and Th...mentioning

confidence: 99%

Phytotherapeutic Approaches to the Prevention of Age-Related Changes and the Extension of Active Longevity

et al. 2022

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Maintaining quality of life with an increase in life expectancy is considered one of the global problems of our time. This review explores the possibility of using natural plant compounds with antioxidant, anti-inflammatory, anti-glycation, and anti-neurodegenerative properties to slow down the onset of age-related changes. Age-related changes such as a decrease in mental abilities, the development of inflammatory processes, and increased risk of developing type 2 diabetes have a significant impact on maintaining quality of life. Herbal preparations can play an essential role in preventing and treating neurodegenerative diseases that accompany age-related changes, including Alzheimer’s and Parkinson’s diseases. Medicinal plants have known sedative, muscle relaxant, neuroprotective, nootropic, and antiparkinsonian properties. The secondary metabolites, mainly polyphenolic compounds, are valuable substances for the development of new anti-inflammatory and hypoglycemic agents. Understanding how mixtures of plants and their biologically active substances work together to achieve a specific biological effect can help develop targeted drugs to prevent diseases associated with aging and age-related changes. Understanding the mechanisms of the biological activity of plant complexes and mixtures determines the prospects for using metabolomic and biochemical methods to prolong active longevity.

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Overview of the Biological Activity of Anthraquinons and Flavanoids of the Plant Rumex Species

Cited by 13 publications

References 106 publications

Preliminary Study on Total Component Analysis and In Vitro Antitumor Activity of Eucalyptus Leaf Residues

Preliminary Study on Total Component Analysis and In Vitro Antitumor Activity of Eucalyptus Leaf Residues

Signaling in Legume–Rhizobia Symbiosis

Phytotherapeutic Approaches to the Prevention of Age-Related Changes and the Extension of Active Longevity

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