Overt gastrointestinal bleeding following haploidentical haematopoietic stem cell transplantation: incidence, outcomes and predictive models

Sun, Xiangming; Su, Yan; Xiao, Lan; Zhang, Yuanyuan; He, Yun; Han, Wei; Chen, Qi; Chen, Huan; Wang, Yu; Cheng, Yifei; Liu, Fengqi; Wang, Feng-Rong; Chen, Yao; Zhang, Gaochao; Mo, Xiao‐Dong; Fu, Hai-Xia; Chen, Yuhong; Wang, Jing‐Zhi; Zhu, Xiaolu; Xu, Lei; Liu, Kai-Yan; Huang, Xiao‐Jun; Zhang, Mengjie

doi:10.1038/s41409-020-01187-5

Cited by 8 publications

(8 citation statements)

References 64 publications

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“…Most of the patients received haploidentical stem cell transplantation. The conditional regimen for these patients was mainly a strategy of modified busulfan/cyclophosphamide and anti‐thymoglobulin (ATG), details were reported in our previously published articles 11–13 . The HLA‐matched recipients mostly received modified BU/CY regimen without ATG.…”

Section: Methodsmentioning

confidence: 99%

“…A total body irradiation (TBI) based regimen was performed on patients who had a history of transplantation and other specific circumstances. The source of hematopoietic stem cells was mostly peripheral blood stem cells and bone marrow stem cells, which were harvested in accordance with the protocol established by our institute 13 . GVHD prophylaxis strategy consists of short‐term MTX, mycophenolate and CsA 11,14 .…”

Section: Methodsmentioning

confidence: 99%

“…The source of hematopoietic stem cells was mostly peripheral blood stem cells and bone marrow stem cells, which were harvested in accordance with the protocol established by our institute. 13 GVHD prophylaxis strategy consists of short-term MTX, mycophenolate and CsA. 11,14 Prophylaxis practices for GVHD and HZ remained consistent and comparable from 2012 to 2017.…”

Section: Conditional Regimens and Gvhd Prophylaxismentioning

confidence: 99%

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RETRACTED: A predictive model of herpes zoster after allogeneic hematopoietic stem cell transplantation: VZV reactivation following antiviral prophylaxis discontinuation

Feng,

Zhao,

et al. 2023

American J Hematol

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Herpes zoster (HZ) refers to the rash appearing on dermatomes due to varicella zoster virus (VZV) reactivation. The incidence of HZ is significantly higher in allogeneic hematopoietic stem cell transplantation (allo‐HSCT) recipients than in non‐HSCT recipients. Although acyclovir prophylaxis is routinely administered to every allo‐HSCT recipient for 1 year after transplantation, some individuals eventually develop late‐onset HZ after completing prophylaxis. Little information is known about the clinical features of HZ after prophylactic antiviral treatment discontinuation, and an effective predictive model of late‐onset HZ needs to be established. A total of 3366 patients who had received allo‐HSCT from 2012 to 2017 were included in our study, among whom 201 developed HZ after 1 year (late‐onset HZ). We designed a nested case–control study to identify potential predictors of late‐onset HZ. Finally, we established a predictive model using binary logistic regression analysis. Age (p < .001), use of immunosuppressants at +1 year (p < .001), CD4‐CD8 ratio at +1 year (p < .001), certain mental disorders (depression, anxiety, insomnia and adjustment disorder) (p < .001), engraftment time of neutrophils (p < .001), and CD8+ cell count at +30 days (p < .001) were independent predictors of late‐onset HZ. A risk grading system was established based on regression coefficients. Discrimination and calibration analysis indicated that the model had good performance. We also identified several predictive factors of the incidence of HZ‐related complications. This is the first scoring system for predicting the incidence of late‐onset HZ after allo‐HSCT. This model can be applied to identify individuals at high risk of late‐onset HZ in the early period after receiving allo‐HSCT.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Conditional Regimens and Gvhd Prophylaxismentioning

confidence: 99%

See 1 more Smart Citation

RETRACTED: A predictive model of herpes zoster after allogeneic hematopoietic stem cell transplantation: VZV reactivation following antiviral prophylaxis discontinuation

Feng,

Zhao,

et al. 2023

American J Hematol

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“…1 The intestinal symptoms of patients with aGVHD after transplantation include refractory diarrhea, severe abdominal pain, bloody stools, and intestinal obstruction, which affect the implantation and even endanger life in severe cases. 23 Peripheral blood mononuclear cells are mainly composed of lymphocytes and monocytes. In our study, patients were transplanted with allogeneic peripheral blood stem cells combined with bone marrow stem cells.…”

Section: Discussionmentioning

confidence: 99%

“…The most common type of aGVHD is intestinal aGVHD 1 . The intestinal symptoms of patients with aGVHD after transplantation include refractory diarrhea, severe abdominal pain, bloody stools, and intestinal obstruction, which affect the implantation and even endanger life in severe cases 23 . Peripheral blood mononuclear cells are mainly composed of lymphocytes and monocytes.…”

Section: Discussionmentioning

confidence: 99%

lnc‐AC145676.2.1‐6‐3 plays an important role in intestinal acute graft‐versus‐host disease through the regulation of interleukin‐1β

Sun

Xia

Liu

et al. 2022

Int J Lab Hematology

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Introduction Acute graft‐versus‐host disease (aGVHD) is one of the major complications of allogeneic hematopoietic stem cell transplantation, and the liver, skin, and gastrointestinal tract are the main target organs. The most common type is intestinal aGVHD. Long noncoding RNAs (lncRNAs) have coregulatory functions and participate in a variety of intracellular regulatory processes. We investigated the expression of lncRNAs and their mechanisms in the development of aGVHD. Methods The participants included 15 patients with aGVHD and 4 healthy controls (HCs). To generate profiles of abnormally expressed lncRNAs, peripheral blood mononuclear cell (PBMC) lncRNAs from four patients and four HCs were validated by high‐throughput sequencing and quantitative real‐time‐PCR (qRT‐PCR). A number of databases, including Gene Ontology, Kyoto Encyclopedia of Genes and Genomes, miRanda, TargetScan, and Metascape, were used for bioinformatics analysis. Bioinformatics analysis indicated that overexpression of lnc‐AC145676.2.1‐6‐3 might induce aGVHD via the interleukin (IL)‐1β axis and a downstream miRNA. After the higher levels of lnc‐AC145676.2.1‐6‐3 in other patients were confirmed by qRT‐PCR, serum IL‐1β, IL‐6, and tumor necrosis factor‐α were measured by enzyme linked immunosorbent assays. Results In our study, a large number of lncRNAs were found in PBMCs of patients with intestinal aGVHD, and bioinformatics analysis showed that the upregulated lncRNA lnc‐AC145676.2.1‐6‐3 probably affected the progression of intestinal aGVHD by regulating the hsa‐miR‐3064‐5p/IL‐1β axis. In addition, the changes in lncRNA expression levels were positively correlated with the clinical characteristics of intestinal aGVHD. Conclusion Our results suggest that lncRNAs in PBMCs may become new biomarkers and therapeutic targets for intestinal aGVHD.

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Clinical characteristics and risk stratification for late-onset herpes zoster following allogeneic hematopoietic stem cell transplantation

Feng,

Zhao,

et al. 2024

Cancer Letters

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Overt gastrointestinal bleeding following haploidentical haematopoietic stem cell transplantation: incidence, outcomes and predictive models

Cited by 8 publications

References 64 publications

RETRACTED: A predictive model of herpes zoster after allogeneic hematopoietic stem cell transplantation: VZV reactivation following antiviral prophylaxis discontinuation

RETRACTED: A predictive model of herpes zoster after allogeneic hematopoietic stem cell transplantation: VZV reactivation following antiviral prophylaxis discontinuation

lnc‐AC145676.2.1‐6‐3 plays an important role in intestinal acute graft‐versus‐host disease through the regulation of interleukin‐1β

Clinical characteristics and risk stratification for late-onset herpes zoster following allogeneic hematopoietic stem cell transplantation

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