2013
DOI: 10.18632/aging.100553
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Abstract: Sir2 is the most intensively discussed longevity gene in current aging research. Although, the gene encoding for a NAD+-dependent histone deacetylase initially was found to extend lifespan of various organisms ranging from yeast to mammals, serious doubts regarding its role in longevity have been expressed recently. In this study, we tested whether tissue-specific overexpression of Sir2 in the adult fat body can extend lifespan when compared to genetically identical controls. We also wanted to elucidate the me… Show more

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Cited by 76 publications
(59 citation statements)
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References 39 publications
(76 reference statements)
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“…This latter experiment illustrates the role of dSir2 in mediating dietary effects on longevity, discussed in greater detail below. A second recent study confirms that dSir2 overexpression increases the life span in flies (Hoffmann et al 2013). …”
Section: Sirtuins and Agingmentioning
confidence: 67%
“…This latter experiment illustrates the role of dSir2 in mediating dietary effects on longevity, discussed in greater detail below. A second recent study confirms that dSir2 overexpression increases the life span in flies (Hoffmann et al 2013). …”
Section: Sirtuins and Agingmentioning
confidence: 67%
“…Decreasing activity of the siRNA pathway through Ago2 and Dicer-2 mutants leads to derepression of TE activity and shortened life span (15,24). Sir2 has a central role in aging, with increased gene dosage shown to extend life span in yeast (2) and in nine of 10 studies in nematodes and flies (25)(26)(27)(28). Hypomorphs of Adar, a negative regulator of the siRNA pathway, also exhibit an extension of life span (21).…”
mentioning
confidence: 99%
“…For example, overexpression of antioxidant enzymes such as SOD1, SOD2 and catalase caused lifespan extension (Orr and Sohal, 1994;Sun and Tower, 1999;Parkes et al, 1998;Sun et al, 2002). Overexpression of a Drosophila homolog of Sirtuin 2 (Sir2) (NAD+-dependent protein deacetylase) in fat bodies also led to an extended lifespan (Banerjee et al, 2012;Hoffmann et al, 2013). Although Sir2 orthologs are considered to be involved in the determination of lifespan in other organisms (Kaeberlein et al, 1999;Tissenbaum and Guarente, 2002), the ubiquitous overexpression of Drosophila Sir2 failed to extend the Drosophila adult lifespan (Burnett et al, 2011).…”
Section: O V E R E X P Re Ss Io N O F D Ro S O Ph I L a O G G1 U S I N Gmentioning
confidence: 99%