volume 5, issue 4, P315-327 2013
DOI: 10.18632/aging.100553
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Abstract: Sir2 is the most intensively discussed longevity gene in current aging research. Although, the gene encoding for a NAD+-dependent histone deacetylase initially was found to extend lifespan of various organisms ranging from yeast to mammals, serious doubts regarding its role in longevity have been expressed recently. In this study, we tested whether tissue-specific overexpression of Sir2 in the adult fat body can extend lifespan when compared to genetically identical controls. We also wanted to elucidate the me…

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