Abstract:A spontaneous fluoroquinolone-resistant mutant (STM1) was isolated from its parent
Salmonella enterica serovar Typhi (S. Typhi)
clinical isolate. Unlike its parent isolate, this mutant has selective resistance to
fluoroquinolones without any change in its sensitivity to various other antibiotics.
DNA gyrase assays revealed that the fluoroquinolone resistance phenotype of the STM1
mutant did not result from alteration of the fluoroquinolone sensitivity of the DNA
gyrase isolated from it. To study the mechanism … Show more
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