2017
DOI: 10.18632/aging.101200
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Abstract: Rab1B has recently been reported to be involved in human cancer, but the role of Rab1B in colorectal cancer (CRC) remains unclear. In this study, we investigated the expression of Rab1B and MMP9 in CRC by qRT-PCR, immunoblot and immunohistochemistry and analyzed the clinical significance. The results show that Rab1B and MMP9 are increased at both mRNA and protein levels in CRC cell lines and tissues, as measured by qRT-PCR and immunoblotting. The high protein expression of Rab1B and MMP9 in 179 CRC tissues is … Show more

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Cited by 29 publications
(19 citation statements)
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References 34 publications
(40 reference statements)
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“…In clinical practice, many oncologists have realized that the TNM staging system alone does not have the optimal predictive value in several human cancers, including ESCC [7,38,39], consistent with our findings. Consequently, additional prognostic biomarkers are required to improve the risk assessment of the TNM staging system.…”
Section: Discussionsupporting
confidence: 89%
“…In clinical practice, many oncologists have realized that the TNM staging system alone does not have the optimal predictive value in several human cancers, including ESCC [7,38,39], consistent with our findings. Consequently, additional prognostic biomarkers are required to improve the risk assessment of the TNM staging system.…”
Section: Discussionsupporting
confidence: 89%
“…Studies have already shown several promising biomarkers for the prediction of chemotherapy for patients with NSCLC, such as excision repair cross-complementing group (ERCC), thymidylate synthase (TYMS), tubulin, and ribonucleotide reductase subunit M1 (RRM1) [23]. Previously in our study, we demonstrated that changes in serum concentrations of MMP-9 in patients with NSCLC during chemotherapy were intimately associated with chemotherapy outcome [12], which was in accordance with a previous study in colorectal cancer [24]. The sensitivity of scMMP-9 was markedly higher than the specificity, indicating that the upregulation of scMMP-9 was beneficial for predicting PD.…”
Section: Discussionsupporting
confidence: 92%
“…7 Disease Markers power for chemotherapy response in patients with NSCLC. MMP-9 plus another protein as a combination is not a special case in our study; likewise, in colorectal cancer, scMMP-9 plus scRab1B also showed powerful predictive importance for chemotherapy outcomes [24].…”
Section: Discussioncontrasting
confidence: 44%
“…Matrix metalloproteinase (MMP) played an important role in degradation of extracellular matrix and basement membranes, and previous studies indicated that the overexpression of matrix metallopeptidase 9 (MMP9) was associated with deep tumor invasion, lymph‐node metastasis, and advanced TNM stage in CRC (Lee et al ., ; Matsuyama et al ., ). But a recent study revealed that overexpression of MMP9 can predict good response to chemotherapy in patients with CRC (Yang et al ., ). Therefore, we hypothesized that in patients with comparable clinicopathological features, those with high expression level of MMP9 may exhibit better survival, which has been suggested by the results in this study.…”
Section: Discussionmentioning
confidence: 97%