Overexpression of PID1 reduces high density lipoprotein level and functionality in swine

Mu, Qingjie; Zhu, Jing; Si, Yanna; Chen, Xiaofeng; Duan, Guangqing; Sun, Shiyu; Fang, Guo-feng; Zeng, Yongqing

doi:10.1002/iub.2135

Cited by 5 publications

(3 citation statements)

References 28 publications

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“…Hence, our results point more precisely towards a function of ARNT2 and TSPYL5 in the early steps of cholesterol synthesis where Lan is formed from Sq. Similarly, previous studies have linked PID1 (Chr 15) to HDL-C level 44 and PEX2 (Chr 4) to levels of HDL-C and TC 45 , whereas the tentative associations in the present study point more precisely towards a function of these loci in the KRPW for cholesterol biosynthesis because the two loci are associated specifically with Lat levels. On the other hand, the associations between Des levels and the two genes ARV1 (Chr 14) and ACSL1 (Chr 15) identify functions of these loci in the BPW of cholesterol biosynthesis.…”

Section: Resultssupporting

confidence: 80%

Inclusion of endophenotypes in a standard GWAS facilitate a detailed mechanistic understanding of genetic elements that control blood lipid levels

Zhang

Cai

Lhomme

et al. 2020

Sci Rep

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Dyslipidemia is the primary cause of cardiovascular disease, which is a serious human health problem in large parts of the world. Therefore, it is important to understand the genetic and molecular mechanisms that regulate blood levels of cholesterol and other lipids. Discovery of genetic elements in the regulatory machinery is often based on genome wide associations studies (GWAS) focused on end-point phenotypes such as total cholesterol level or a disease diagnosis. In the present study, we add endophenotypes, such as serum levels of intermediate metabolites in the cholesterol synthesis pathways, to a GWAS analysis and use the pig as an animal model. We do this to increase statistical power and to facilitate biological interpretation of results. Although the study population was limited to ~ 300 individuals, we identify two genome-wide significant associations and ten suggestive associations. Furthermore, we identify 28 tentative associations to loci previously associated with blood lipids or dyslipidemia associated diseases. The associations with endophenotypes may inspire future studies that can dissect the biological mechanisms underlying these previously identified associations and add a new level of understanding to previously identified associations.

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Section: Resultssupporting

confidence: 80%

Inclusion of endophenotypes in a standard GWAS facilitate a detailed mechanistic understanding of genetic elements that control blood lipid levels

Zhang

Cai

Lhomme

et al. 2020

Sci Rep

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“…The existing literature has observed similar phenomena in other populations. As the main component of metabolic syndrome, obesity was often accompanied by dyslipidemia [ 36 , 37 , 38 , 39 , 40 , 41 ]. At the same time, studies have shown that adult dyslipidemia was directly related to the increase in BMI [ 9 , 42 ].…”

Section: Discussionmentioning

confidence: 99%

The Effect of BMI on Blood Lipids and Dyslipidemia in Lactating Women

Yu³

et al. 2022

Nutrients

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Background: This study aimed to explore the correlation between body mass index (BMI) and dyslipidemia and the optimal cut-off point for BMI to distinguish the risk of dyslipidemia in lactating women. Methods: A total of 2295 lactating women subjects were included in this study, all within 2 years postpartum. All samples were from “China Children and Lactating Mothers Nutritional Health Surveillance (2016–2017)”. BMI, blood lipids, demographic information, lifestyle habits, and other serum indicators were obtained in this survey. Generalized linear model, logistic regression, restricted cubic spline (RCS) and ROC curve analysis were used to evaluate the relationship among BMI, blood lipids, and dyslipidemia. Results: BMI in lactating women was positively correlated with total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), but negatively correlated with high-density lipoproteincholesterol (HDL-C) (p < 0.05). Higher BMI in lactating women was associated with higher ORs of dyslipidemia (hypercholesterolemia, hypertriglyceridemia, high-LDL-cholesterolemia, low HDL-cholesterolemia) (p < 0.05). These associations were stable across age groups, breastfeeding child age (months), parity, physical activity level, fasting plasma glucose (FPG), and hemoglobin. These factors did not interact with this relationship (p > 0.05). The optimal cut-off point for BMI was 24.85 kg/m2 determined by using ROC analysis, which can distinguish the risk of dyslipidemia. Conclusions: BMI was positively correlated with risk of dyslipidemia. Maintaining an ideal weight may prevent dyslipidemia in lactating women, and BMI is recommended to be controlled below 24.85 kg/m2.

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“…Four genes previously reported in the literature with an additive genetic effect on precocity were found on Chr2. The PID1 gene has been identified in transgenic pigs, showing higher expression in obese animals [ 69 ], in which PID1 overexpression resulted in the reduction in serum HDL-cholesterol and apolipoprotein A1 levels. The role of the PID1 gene in human lipid metabolism is well known because this gene acts by reducing the sensitivity of adipocytes to insulin mediated by the interaction of domain 1 of phosphotyrosine with the lipoprotein receptor [ 70 ].…”

Section: Discussionmentioning

confidence: 99%

Genome-Wide Association Analysis Reveals Novel Loci Related with Visual Score Traits in Nellore Cattle Raised in Pasture–Based Systems

Machado

Brito

Martins

et al. 2022

Animals

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Body conformation traits assessed based on visual scores are widely used in Zebu cattle breeding programs. The aim of this study was to identify genomic regions and biological pathways associated with body conformation (CONF), finishing precocity (PREC), and muscling (MUSC) in Nellore cattle. The measurements based on visual scores were collected in 20,807 animals raised in pasture-based systems in Brazil. In addition, 2775 animals were genotyped using a 35 K SNP chip, which contained 31,737 single nucleotide polymorphisms after quality control. Single-step GWAS was performed using the BLUPF90 software while candidate genes were identified based on the Ensembl Genes 69. PANTHER and REVIGO platforms were used to identify key biological pathways and STRING to create gene networks. Novel candidate genes were revealed associated with CONF, including ALDH9A1, RXRG, RAB2A, and CYP7A1, involved in lipid metabolism. The genes associated with PREC were ELOVL5, PID1, DNER, TRIP12, and PLCB4, which are related to the synthesis of long-chain fatty acids, lipid metabolism, and muscle differentiation. For MUSC, the most important genes associated with muscle development were SEMA6A, TIAM2, UNC5A, and UIMC1. The polymorphisms identified in this study can be incorporated in commercial genotyping panels to improve the accuracy of genomic evaluations for visual scores in beef cattle.

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Overexpression of PID1 reduces high density lipoprotein level and functionality in swine

Cited by 5 publications

References 28 publications

Inclusion of endophenotypes in a standard GWAS facilitate a detailed mechanistic understanding of genetic elements that control blood lipid levels

Inclusion of endophenotypes in a standard GWAS facilitate a detailed mechanistic understanding of genetic elements that control blood lipid levels

The Effect of BMI on Blood Lipids and Dyslipidemia in Lactating Women

Genome-Wide Association Analysis Reveals Novel Loci Related with Visual Score Traits in Nellore Cattle Raised in Pasture–Based Systems

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