Overexpression of p53 tumor suppressor protein in porokeratosis

Magee, J. W.

doi:10.1001/archderm.130.2.187

Cited by 26 publications

(16 citation statements)

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“…Taken together with previous results (7)(8)(9)(10), these data suggest that p53 overexpression may be common in all types of porokeratosis regardless of race. However, p53 overexpression was not detected in all the cases examined.…”

Section: Resultssupporting

confidence: 87%

Immunohistochemical Detection of p53 Tumor Suppressor Protein in Porokeratosis

Urano

Sasaki

Ninomiya

et al. 1996

The Journal of Dermatology

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We examined 9 Japanese cases of porokeratosis (4 of the plaque type, 2 of disseminated superficial actinic porokeratosis, 2 of disseminated superficial porokeratosis, and one of giant porokeratosis) for the expression of p53 tumor suppressor protein immunohistochemically, using two anti-p53 antibodies, CM1 and DO1. The same results were obtained with both antibodies. The epidermis central to the cornoid lamellae was positive in 8 of 9 specimens. On the other hand, the peripheral epidermis was positive in 2 of the 9 cases. The epidermis beneath the cornoid lamellae was positive in 3 of the 9 cases. The frequency of p53 positivity was significantly higher in the epidermis central to cornoid lamellae over that beneath or peripheral to them (Fisher's exact probability test, p < 0.05). The majority of squamous cell carcinoma cells arising on giant porokeratosis stained with CM1 and DO1. These data may suggest that the abnormal p53 expression has some relevance to the skin carcinogenesis of porokeratosis.

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Section: Resultssupporting

confidence: 87%

Immunohistochemical Detection of p53 Tumor Suppressor Protein in Porokeratosis

Urano

Sasaki

Ninomiya

et al. 1996

The Journal of Dermatology

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“…9 Increased expression of the p53 gene product has been demonstrated under or adjacent to the cornoid lamella of porokeratotic lesions; this unusual overexpression is thought to be associated with the findings of early focal keratinocytes apoptosis in the lesional epidermis, resulting in abnormal terminal differentiation of keratinocytes and dysregulation of loricrin expression, a precursor protein expressed in the final stage of keratinization, cross-linked to form the cornified envelope. 10,11 Interestingly, in the 5 cases (including our patient) of suspected paraneoplastic disseminated superficial porokeratosis reported in literature (Table I), the underlying tumors share a common characteristic, that is, the well-demonstrated pathogenetic role of p53 in carcinogenesis. 3,4 Although p53 protein is frequently overexpressed in human malignancies, we concur with Lee et al 4 that a pathogenic link between malignancy and disseminated superficial porokeratosis might induce the activation, in genetically predisposed subjects, of keratinocyte p53 pathway, …”

Section: Discussionmentioning

confidence: 70%

Simultaneous development and parallel course of disseminated superficial porokeratosis and ovarian cancer: Coincidental association or true paraneoplastic syndrome?

Cannavò

Borgia

Adamo

et al. 2008

Journal of the American Academy of Dermatology

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“…Among these loci, a genetic locus for DSP has been found at 18p11.3 7 . Also, overexpression of p53 has been reported in porokeratosis 8 . Recently, frequent p53 overexpression has been reported and might be related to the carcinogenic potential of porokeratosis.…”

Section: Discussionmentioning

confidence: 94%

A Case of Inflammatory Disseminated Superficial Porokeratosis in a Colon Cancer Patient

Choi

Kim

2009

Ann Dermatol

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Disseminated superficial porokeratosis (DSP) is a specific disorder of keratinization. Genetic studies show that DSP is an autosomal dominant trait. Clinically, the lesions show a sharply demarcated and hyperkeratotic plaque with central atrophy. The lesions appear mainly in the extremities and generally develop with bilateral symmetry. Unusual cases of DSP accompanied by severe pruritus have been reported as "eruptive pruritic papular porokeratosis" or "inflammatory DSP." Histopathologically, inflammatory DSP is characterized by the presence of cornoid lamella with a dense infiltration of eosinophils and lymphocytes in the perivascular area of the upper dermis. Here we report a case of inflammatory DSP in a 84-year-old man with colon cancer who presented with multiple hyperpigmented atrophic macules. (Ann Dermatol 21(2) 150∼153, 2009)

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Overexpression of p53 tumor suppressor protein in porokeratosis

Cited by 26 publications

References 0 publications

Immunohistochemical Detection of p53 Tumor Suppressor Protein in Porokeratosis

Immunohistochemical Detection of p53 Tumor Suppressor Protein in Porokeratosis

Simultaneous development and parallel course of disseminated superficial porokeratosis and ovarian cancer: Coincidental association or true paraneoplastic syndrome?

A Case of Inflammatory Disseminated Superficial Porokeratosis in a Colon Cancer Patient

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