Overexpression of interleukin-6 in human basal cell carcinoma cell lines increases anti-apoptotic activity and tumorigenic potency

Jee, Shiou‐Hwa; Shen, Shing Chuan; Hc, Chiu; Tsai, Wei Ling; Kuo, Min-Liang

doi:10.1038/sj.onc.1204076

Cited by 118 publications

(105 citation statements)

References 46 publications

(32 reference statements)

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“…In addition, interleukin (IL) -1 and -6 network is upregulated (Vidal-Vanaclocha et al, 2000;Miki et al, 2004). Interleukin 1 is involved in the development of metastasis in animal studies and IL-6, apart from being a growth factor, promotes resistance to apoptosis (Vidal-Vanaclocha et al, 1994Chauhan et al, 1997;Frassanito et al, 2001;Jee et al, 2001). This creates a microenvironment that favours tumour angiogenesis, proliferation, growth and metastases.…”

Section: Discussionmentioning

confidence: 99%

C-reactive protein as a predictor of prognosis following curative resection for colorectal liver metastases

et al. 2007

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There is increasing evidence that systemic inflammatory response has a positive correlation with a poorer outcome in patients undergoing resection for solid tumours. The aim of this study was to analyse the impact of an elevated C-reactive protein (CRP), an outcome following curative resection for colorectal liver metastases. One hundred and seventy patients who underwent curative resection for colorectal liver metastases were included in the study. Laboratory measurements of haemoglobin, white cell, platelets, albumin and CRP were taken on the day before surgery. Elevated CRP (410 mg l À1 ) was present in 54 (31.8%) patients. The median survival of patients with an elevated CRP was 19 months (95% CI 7.5 -31.2 months) compared to 42.8 months (95% CI 33.2 -52.5 months) for those with a normal CRP, P ¼ 0.004. Similarly, when assessing disease-free survival, patients with an elevated CRP had poorer disease-free survival (median of 11.8 months (95% CI 6.4 -17.3) compared to median of 15.1 months (95% CI 11.1 -19.1)), P ¼ 0.043. The result of the study showed that an elevated preoperative CRP is a predictor of poor outcome in patients undergoing curative resection for colorectal liver metastases.

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Section: Discussionmentioning

confidence: 99%

C-reactive protein as a predictor of prognosis following curative resection for colorectal liver metastases

et al. 2007

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“…Survival effects have been reported for IL-6 in a variety of malignancies such as basal cell carcinoma, prostate cancer, esophageal carcinoma and multiple myeloma (38,(43)(44)(45). Tumor growth can be promoted by cell survival resulting from modulation of apoptosis by cytokines.…”

Section: Discussionmentioning

confidence: 99%

Over-expression of interleukin-6 enhances cell survival and transformed cell growth in human malignant cholangiocytes

Meng¹,

Yamagiwa²,

Ueno³

et al. 2006

Journal of Hepatology

115

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“…There are a number of possible explanations. Firstly, that an elevated Creactive protein identifies tumours capable of producing significant amounts of proinflammatory cytokines, in particular interleukin-6 (Kinoshita et al, 1999;McKeown et al, 2004) and therefore with the potential for more rapid growth of tumour cells (Jee et al, 2001;Trikha et al, 2003). Also, that an elevated C-reactive protein identifies those patients with T-lymphocyte impairment (Maccio et al, 1998;Canna et al, 2005) or patients with a proangiogenic environment (Kofler et al, 2005;Xavier et al, 2006) allowing unrestrained tumour growth and dissemination.…”

Section: Discussionmentioning

confidence: 99%

The relationship between the preoperative systemic inflammatory response and cancer-specific survival in patients undergoing potentially curative resection for renal clear cell cancer

et al. 2006

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The relationship between tumour stage, grade (Fuhrman), performance status (ECOG), a combined score (UCLA Integrated Staging System, UISS), systemic inflammatory response (elevated C-reactive protein concentration), and cancer-specific survival was examined in patients undergoing potentially curative resection for renal clear cell cancer (n ¼ 100). On univariate survival analysis, sex (P ¼ 0.050), tumour stage (P ¼ 0.001), Fuhrman grade (Po0.001), UISS (Po0.001), C-reactive protein (P ¼ 0.002) were significant predictors of survival. On multivariate analysis with sex, UISS and C-reactive protein entered as covariates, only UISS (HR 2.70, 95% CI 1.00 -7.30, P ¼ 0.050) and C-reactive protein (HR 4.00, 95% CI 1.21 -13.31, P ¼ 0.024) were significant independent predictors of survival. The presence of a preoperative systemic inflammatory response predicts poor cancer-specific survival in patients who have undergone potentially curative resection for renal clear cell cancer.

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Overexpression of interleukin-6 in human basal cell carcinoma cell lines increases anti-apoptotic activity and tumorigenic potency

Cited by 118 publications

References 46 publications

C-reactive protein as a predictor of prognosis following curative resection for colorectal liver metastases

C-reactive protein as a predictor of prognosis following curative resection for colorectal liver metastases

Over-expression of interleukin-6 enhances cell survival and transformed cell growth in human malignant cholangiocytes

The relationship between the preoperative systemic inflammatory response and cancer-specific survival in patients undergoing potentially curative resection for renal clear cell cancer

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