Overexpression of Insulin-like Growth Factor-1 Receptor Is Associated With Penile Cancer Progression

Abstract

Objective To evaluate insulin-like growth factor-1 receptor (IGF1R) expression in penile cancer and its association with oncologic outcomes. Methods Tissue microarrays were constructed from 53 patients treated at our institution. Expression of IGF1R was evaluated using a Her2-like scoring system. Overexpression was defined as 1+ or greater membranous staining. Association of IGF1R expression with pathologic features was assessed with comparative statistics, and association with local recurrence, progression to nodal or distance metastases or death was assessed with Kaplan-Meier survival analysis and Cox proportional hazard regression models. Results Overall, IGF1R overexpression was seen in 33 (62%) cases. With a median follow-up of 27.8 months, IGF1R overexpression was associated with inferior progression-free survival (PFS) (p=0.003). In a multivariable model controlling for grade, T stage, PNI and lymphovascular invasion, IGF1R expression was independently associated with disease progression (HR 2.3, 95%CI 1.1–5.1, p = 0.03. Comparing patients without IGF1R over-expression to those with over-expression, 5 year PFS was 94.1% vs 45.8%. Conclusions IGF1R over-expression was associated with inferior PFS in penile cancer. Drugs that target IGF1R and downstream messengers may have a therapeutic benefit in patients that exhibit IGF1R over-expression.

Overexpression of lncRNA EGFR‑AS1 is associated with a poor prognosis and promotes chemotherapy resistance in non‑small cell lung cancer

“…IGF1R is a transmembrane glycoprotein that is important in a number of biological functions (23). Previous studies have demonstrated that IGF1R is vital in cancer development and progression (24)(25)(26). IGF1R can be used as a novel marker for targeted therapy for several types of tumor, including glioma, colorectal cancer and breast cancer (27)(28)(29).…”

Hypomethylation at H19DMR in penile squamous cell carcinoma is not related to HPV infection

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Non-Coding RNA in Penile Cancer

“…This receptor plays a critical role in cell proliferation, differentiation, and malignant transformation. Protein overexpression of IGF1R has been associated with lower disease-free survival in penile cancer ( 47 ).…”