2008
DOI: 10.1111/j.1365-2184.2007.00498.x
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Abstract: Although we cannot definitely establish FASN as a novel oncogene in breast cancer, this study reveals for the first time that exacerbated endogenous FA biosynthesis in non-cancerous epithelial cells is sufficient to induce a cancer-like phenotype functionally dependent on the HER1/HER2 duo. These findings may perhaps radically amend our current perspective of endogenously synthesized fat, as on its own, it appears to actively increase signal-to-noise ratio in the HER1/HER2-driven progression of human breast ep… Show more

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Cited by 168 publications
(131 citation statements)
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“…Kim et al [7] discovered a positive feedback loop between Wnt and ERK pathways. It has also been reported that there is a regulatory loop between fatty acid synthase (FASN) and ERK pathway dependent on the HER1/HER2 [8] . Cheng et al [9] identified a positive feedback loop in which Ras signaling promoted CD44v6 splicing, and CD44v6 then sustained late Ras signaling.…”
Section: Introductionmentioning
confidence: 99%
“…Kim et al [7] discovered a positive feedback loop between Wnt and ERK pathways. It has also been reported that there is a regulatory loop between fatty acid synthase (FASN) and ERK pathway dependent on the HER1/HER2 [8] . Cheng et al [9] identified a positive feedback loop in which Ras signaling promoted CD44v6 splicing, and CD44v6 then sustained late Ras signaling.…”
Section: Introductionmentioning
confidence: 99%
“…Recently Mukherjee et al [117] demonstrated that bioactive lipid lysophosphatidic acid (LPA) induces FAS expression and lipogenesis through LPA2-G12/13-Rho-SREBP signaling pathway in ovarian cancer cells. Moreover over-expression of FAS in non-cancerous epithelial cells is sufficient to induce a cancer-like phenotype through the induction of HER1/HER2 [127], therefore FAS over-expression may play a role in carcinogenesis. Furthermore FAS overexpression is found to be associated with the advanced stage of colorectal cancer and liver metastasis, thus it may also play a role in the progression of cancer [128].…”
Section: Fatty Acid Synthasementioning
confidence: 99%
“…To definitely establish a role of FASN-catalyzed endogenous FA biogenesis on HER2 ECD shedding, we took advantage of an in vitro model previously developed in our laboratory in which lowpassage HBL100 cells (an SV40-transformed cell line for near-normal gene expression in the breast epithelium) were transiently transfected with plasmid pCMV6-XL4 carrying full-length human FASN cDNA (gi: NM_004104) (24). HBL100 cells transiently transfected with pCMV6-XL4/ FASN exhibited an enhanced endogenous lipid synthesis as well as an increased phosphorylation status of the 1248 Tyr residue of HER2 (24). Here, immunoblotting analyses revealed that FASN protein accumulated significantly in the extracellular milieu obtained from HBL100 cells engineered to overexpress human FASN gene (Fig.…”
Section: Fasn Activity Regulates Her2 Ecd Shedding In Cultured Cancermentioning
confidence: 99%
“…Transient overexpression of human FASN gene in HBL100 breast epithelial cells was performed as previously described (24).…”
Section: Generation Of Her2-overexpressing Mcf-7 Cellsmentioning
confidence: 99%
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