Overexpression of Claudin-1 is Associated with Advanced Clinical Stage and Invasive Pathologic Characteristics of Oral Squamous Cell Carcinoma

Sappayatosok, Kraisorn; Phattarataratip, Ekarat

doi:10.1007/s12105-014-0559-z

Cited by 37 publications

(37 citation statements)

References 38 publications

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“…High expression of CLDN-1 in our study was associated with the histological grades which allowed us to assume that CLDN-1 might be involved in the progression of cancer either directly or indirectly. Similar results were observed by Sappayatosok et al 37 , who reported an association of CLDN-1 overexpression with the advanced clinical stage. Also, deregulation and delocalization of CLDN-1 from the cell membrane to the cytoplasm to the nucleus during the progression of oral cancer confirms its unidentified role in cell signaling.…”

Section: Discussionsupporting

confidence: 90%

Joint detection of claudin‐1 and junctional adhesion molecule‐A as a therapeutic target in oral epithelial dysplasia and oral squamous cell carcinoma

Upadhaya

Barhoi

Giri

et al. 2019

J of Cellular Biochemistry

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Abnormal expression of claudin‐1 (CLDN‐1) and junctional adhesion molecule‐A (JAM‐A) has been described in certain malignancies but their clinical relevance is poorly understood. The present study aims to elucidate the role of CLDN‐1 and JAM‐A in oral epithelial dysplasia (OED) and oral squamous cell carcinoma (OSCC). Changes in the expression of these proteins were identified immunohistochemically on tissue sections from patients with OED and OSCC and compared with control. A correlation between the expression level of proteins and clinicopathological features was analyzed by Pearson's correlation χ2 test. The survival curve of the follow‐up data was estimated by the Kaplan‐Meier method followed by the log‐rank test. CLDN‐1 and JAM‐A were highly expressed in OED and OSCC tissues when compared to control. Also, delocalization of CLDN‐1 from the membrane to the cytoplasm to the nucleus was observed as the cell proceeds from normal to malignancy. Increased expression of CLDN‐1 and JAM‐A in both OED and OSCC were concomitant with histological grades. In addition, increased JAM‐A was associated with perineural invasion of cancer cells. A positive correlation between the expression level of proteins was observed in OED (r = 0.733) and OSCC (r = 0.577). Kaplan‐Meier analysis in patients with OSCC showed that the survival rate was lower in patients with high CLDN‐1 and high JAM‐A expression compared to low expressed patients. To conclude, the elevated level and delocalization of CLDN‐1 and JAM‐A suggest their use as tumor markers. A positive correlation between CLDN‐1 and JAM‐A suggests joint detection of these proteins as a future diagnostic tool in oral precancerous and cancerous conditions.

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Section: Discussionsupporting

confidence: 90%

Joint detection of claudin‐1 and junctional adhesion molecule‐A as a therapeutic target in oral epithelial dysplasia and oral squamous cell carcinoma

Upadhaya

Barhoi

Giri

et al. 2019

J of Cellular Biochemistry

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“…The areas in one study (total 99 patients) included the tongue (44%), floor of mouth (24%), floor of mouth and tongue (13%), alveoli (13%), buccal mucosa (5%), and retromolar trigone (1%) . Those of the other study (total 45 patients) included the gingiva (38%), tongue (16%), floor of mouth (18%), buccal mucosa (13%), hard palate (7%), and alveolar mucosa (9%) . In the present study, we focused on TSCC, which may explain the different conclusions obtained between the previous and present studies.…”

Section: Discussionmentioning

confidence: 49%

“…Previously, claudin‐1 overexpression was reported to be associated with invasive pathological characteristics in OSCC in two independent studies which analyzed various regions in the oral cavity . The areas in one study (total 99 patients) included the tongue (44%), floor of mouth (24%), floor of mouth and tongue (13%), alveoli (13%), buccal mucosa (5%), and retromolar trigone (1%) .…”

Section: Discussionmentioning

confidence: 99%

Intracellular claudin‐1 at the invasive front of tongue squamous cell carcinoma is associated with lymph node metastasis

et al. 2019

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This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. AbstractClaudins are the major component of tight junctions, which form a primary barrier to paracellular diffusion and maintain cell polarity in normal epithelia and endothelia. In cancer cells, claudins play additional roles besides serving as components of the tight junctions, and participate in anoikis or invasion. Among the claudin family proteins, claudin-1 has the most promising potential, both diagnostically and prognostically, in many types of cancers, including oral, gastric, liver, and colon cancers.However, conflicting results have been reported in relation to the degree of claudin-1 expression and the prognosis, suggesting that the expression level of claudin-1 alone is not sufficient to analyze the relationship between claudin-1 and cancer progression. As endocytic trafficking of claudin-1 has been reported in several epithelial cell types in vitro, we aimed to determine whether intracellular localization of claudin-1 is the missing aspect between claudin-1 and cancer. We investigated the expression of claudin-1 in 83 tongue squamous cell carcinoma (TSCC) pathological specimens.Although the expression level of claudin-1 based on immunohistochemistry was not associated with TSCC progression, within the high claudin-1 expression group, the incidence of intracellular localization of claudin-1 was correlated with cervical lymph node metastasis. In an in vitro experiment, claudin-1 was constitutively internalized in TSCC-derived cells. Motility of TSCC-derived cells was increased by deficiency of claudin-1, suggesting that the decrease in cell-surface claudin-1 promoted the cell migration. Therefore, intracellular localization of claudin-1 at the invasion front may represent a promising diagnostic marker of TSCC. K E Y W O R D Sclaudin-1, endocytosis, invasion front, metastasis, tongue squamous cell carcinoma

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“…The authors of the study further revealed elevated expression of CLDN-1 in OSC-4 and NOS-2 cell lines which are highly invasive [129]. One study demonstrated the association of high CLDN-1 expression with aggressive histopathologic features such as perineural and vascular invasion and suggested that CLDN-1 might be directly or indirectly involved in the progression of OSCC [130]. Another study found that the absence of CLDN-1 was associated with poorly differentiated tumors [131].…”

Section: Claudin-1 and Oral Squamous Cell Carcinomamentioning

confidence: 94%

Claudin-1, A Double-Edged Sword in Cancer

Bhat

Syed

Therachiyil

et al. 2020

IJMS

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Claudins, a group of membrane proteins involved in the formation of tight junctions, are mainly found in endothelial or epithelial cells. These proteins have attracted much attention in recent years and have been implicated and studied in a multitude of diseases. Claudins not only regulate paracellular transepithelial/transendothelial transport but are also critical for cell growth and differentiation. Not only tissue-specific but the differential expression in malignant tumors is also the focus of claudin-related research. In addition to up- or down-regulation, claudin proteins also undergo delocalization, which plays a vital role in tumor invasion and aggressiveness. Claudin (CLDN)-1 is the most-studied claudin in cancers and to date, its role as either a tumor promoter or suppressor (or both) is not established. In some cancers, lower expression of CLDN-1 is shown to be associated with cancer progression and invasion, while in others, loss of CLDN-1 improves the patient survival. Another topic of discussion regarding the significance of CLDN-1 is its localization (nuclear or cytoplasmic vs perijunctional) in diseased states. This article reviews the evidence regarding CLDN-1 in cancers either as a tumor promoter or suppressor from the literature and we also review the literature regarding the pattern of CLDN-1 distribution in different cancers, focusing on whether this localization is associated with tumor aggressiveness. Furthermore, we utilized expression data from The Cancer Genome Atlas (TCGA) to investigate the association between CLDN-1 expression and overall survival (OS) in different cancer types. We also used TCGA data to compare CLDN-1 expression in normal and tumor tissues. Additionally, a pathway interaction analysis was performed to investigate the interaction of CLDN-1 with other proteins and as a future therapeutic target.

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Overexpression of Claudin-1 is Associated with Advanced Clinical Stage and Invasive Pathologic Characteristics of Oral Squamous Cell Carcinoma

Cited by 37 publications

References 38 publications

Joint detection of claudin‐1 and junctional adhesion molecule‐A as a therapeutic target in oral epithelial dysplasia and oral squamous cell carcinoma

Joint detection of claudin‐1 and junctional adhesion molecule‐A as a therapeutic target in oral epithelial dysplasia and oral squamous cell carcinoma

Intracellular claudin‐1 at the invasive front of tongue squamous cell carcinoma is associated with lymph node metastasis

Claudin-1, A Double-Edged Sword in Cancer

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