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Cited by 159 publications
(160 citation statements)
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“…To date, the proto-oncogene Bmi-1 has been reported to be up-regulated in a large number of neoplasias, namely in lymphomas [27], cerebral tumours [26], breast cancer [13] and other epithelial tumours [28,29] and to be an oncogene associated with poor prognosis in various tumours [12]. To investigate whether or not the abnormal expression of Bmi-1 is involved in the pathogenesis of ovarian carcinoma, in the present study, the protein expression of Bmi-1 was examined firstly by IHC in normal ovaries, benign and borderline epithelial ovarian tumors, and malignant epithelial cancers.…”
Section: Discussionmentioning
confidence: 99%
“…To date, the proto-oncogene Bmi-1 has been reported to be up-regulated in a large number of neoplasias, namely in lymphomas [27], cerebral tumours [26], breast cancer [13] and other epithelial tumours [28,29] and to be an oncogene associated with poor prognosis in various tumours [12]. To investigate whether or not the abnormal expression of Bmi-1 is involved in the pathogenesis of ovarian carcinoma, in the present study, the protein expression of Bmi-1 was examined firstly by IHC in normal ovaries, benign and borderline epithelial ovarian tumors, and malignant epithelial cancers.…”
Section: Discussionmentioning
confidence: 99%
“…Bmi-1 plays an essential role in maintaining the self-renewal of normal and malignant human mammary stem cells [122]. Over-expression of Bmi-1 is reported and correlated to poor clinical prognosis in solid tumors of breast [123], lung [124] and colon [125] cancers; to name but a few. Silva et al [98] investigated Bmi-1 mRNA expression in plasma of a cohort of patients presenting with various subtypes and stages of breast cancer.…”
Section: Bmi-1mentioning
confidence: 99%
“…The specimens were collected and processed according to the guidelines of the University of California at Los Angeles institutional review board. Immunohistochemistry was carried out with anti-Bmi-1 antibody (H-99, Santa Cruz, CA, USA) on 4-mm-thick sections according to the methods described elsewhere (Kim et al, 2004a). The samples were counterstained with haematoxylin.…”
Section: Bmi-1 Gene Amplification Studymentioning
confidence: 99%