Overall survival, prognostic factors, and repeated surgery in a consecutive series of 516 patients with glioblastoma multiforme

Helseth, Ragnhild; Helseth, Eirik; Johannesen, Tom Børge; Langberg, Carl W.; Lote, Knut; Rønning, Pål; Scheie, David; Vik, Anne; Meling, Torstein R.

doi:10.1111/j.1600-0404.2010.01350.x

Cited by 175 publications

(162 citation statements)

References 28 publications

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“…The MST of the patients in this group was 12 months (CI 95%, 9-15). In the subtotal resection group, 3 (7.7%) of the 39 patients in this group were alive, and the patients' MST was 8 months (CI 95%, [5][6][7][8][9][10][11]. No statistically significant difference was detected in the effect of tumor resection groups on survival times (P > 0.05; Table 2).…”

Section: Extent Of Resectionmentioning

confidence: 91%

“…P > 0.05: there were no statistically significant correlation with life expectancy. surgical intervention and survival, the appropriate method is consideration of tumor localization and the extent of resection, which may vary depending on tumor localization (3,5,11).…”

Section: The Extent Of Resection and Functional Localizationsmentioning

confidence: 99%

“…Other studies reported that the extent of resection had no effect on survival (7,13). Some studies on general prognostic factors have reported that resection size has a favorable effect on survival time (2,3,5,14). Aggressive surgical resection has less to do with prolonging patients' lifespans (15).…”

Section: The Extent Of Resection and Functional Localizationsmentioning

confidence: 99%

“…Aggressive therapies administered to old patients are less effective, whereas they prolong survival times in young patients (5,15).…”

Section: Patient Agementioning

confidence: 99%

“…In summary, there is strong evidence of the relationship between adult patients' young ages and longer survival times (3,(5)(6)(7). Therefore, when medical professionals assess the effect of aggressive surgical intervention on the patients' survival, they should consider the age factor (18).…”

Section: Patient Agementioning

confidence: 99%

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Prognostic factors in patients with glioblastoma multiforme (clinical research)

Ekici¹,

Bulut²,

Tucer³

et al. 2013

Turk J Med Sci

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A novel azo derivative, 2,3,4,6 -tetrahydroxy-3 -sulfoazobenzene (THSA), was synthesized by using pyrogallol. The acid dissociation constants, or K a values, of THSA were determined by the UV-visible spectroscopic technique. The protonation and deprotonation behaviors of the title molecule were studied from the super basic to the super acid region (i.e. 10 N NaOH to 98% H 2 SO 4) , including the pH region. A selective and sensitive UV-visible spectrophotometric method was devised for determination of aluminum by using this ligand. The developed method was successfully applied to an alunite mineral and to pharmaceutical preparations for the determination of aluminum.

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Section: Extent Of Resectionmentioning

confidence: 91%

Section: The Extent Of Resection and Functional Localizationsmentioning

confidence: 99%

Section: The Extent Of Resection and Functional Localizationsmentioning

confidence: 99%

“…Aggressive therapies administered to old patients are less effective, whereas they prolong survival times in young patients (5,15).…”

Section: Patient Agementioning

confidence: 99%

Section: Patient Agementioning

confidence: 99%

See 3 more Smart Citations

Prognostic factors in patients with glioblastoma multiforme (clinical research)

Ekici¹,

Bulut²,

Tucer³

et al. 2013

Turk J Med Sci

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Circulating miR‐26a and miR‐21 as biomarkers for glioblastoma multiform

ParvizHamidi

Haddad

Ostadrahimi

et al. 2018

Biotech and App Biochem

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Glioblastoma multiform is the most common and lethal primary central nervous system tumor. Circulating microRNAs (miRNAs), present in cell-free bodily fluids, have been gaining importance as cancer biomarkers. The primary aim of this study was to assess whether circulating miRNA-128, -21, and -26a in glioblastoma patients can be used as diagnostic biomarkers. Venous blood samples were collected from 11 noncancerous volunteers and 15 glioblastoma patients preand post operation. Also, tissue tumor samples were obtained intra-operationally to assay consistency of miRNA levels in serum and tissue samples. Serum and tissue levels of miRNAs were determined by quantitative reverse transcription PCR. miR-21 and miR-26a were both significantly upregulated in pre-and postoperation serum samples of glioblastoma patients compared with the serum samples of noncancerous controls. We found that all three miR-128, -21, and -26a expression levels were reduced in postoperative serum samples compared with pre-operative serum samples, though this decrease was only significant for miR-26a. The serum miR-26a and miR-21 upregulation in glioblastoma patients compared to noncancerous controls and their downregulation in postoperative serum from glioblastoma patients suggest that these miRNAs could be used as serum-derived miRNA biomarkers for glioblastoma.

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Inhibition of tumor formation and redirected differentiation of glioblastoma cells in a xenotypic embryonic environment

Joel

Sandberg

Boulland

et al. 2013

Developmental Dynamics

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Background: Tissue microenvironment plays key roles in regulating the progression of aggressive tumors. Tumors are uncommon in the early embryo, suggesting that embryonic tissue microenvironments are nonpermissive for tumors. Yet, the effects of embryonic tissue microenvironments on tumor cells have not been extensively studied. We have, therefore, tested the behavior of human glioblastoma multiforme (GBM) cells transplanted into a central neural tissue microenvironment in the chicken embryo. Results: GBM cells were cultured as spheres to enrich for GBM stem cells (GSCs) and transduced with GFP for identification. Within the proliferative embryonic neural tissue, GSC-enriched GBM cells exhibited reduced proliferation and survival, altered gene expression, and formed no tumors, in marked contrast to their aggressive behavior in vitro and tumor formation in other tissue microenvironments including the chorioallantoic membrane of the chicken embryo and the brain of adult severe combined immunodeficiency (SCID) mice. Surviving cells in the spinal neural tube exhibited tumor-atypical expression profiles of neuron-, glia-, stem cell-, and tumor-related genes. Conclusions: Embryonic neural tissue provides a poor environment for GBM cell survival and tumor formation, and redirects differentiation toward a more benign phenotype. Understanding the anti-tumorigenic effects of this embryonic tissue microenvironment could provide opportunities to develop novel therapies for GBM treatment.

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Overall survival, prognostic factors, and repeated surgery in a consecutive series of 516 patients with glioblastoma multiforme

Cited by 175 publications

References 28 publications

Prognostic factors in patients with glioblastoma multiforme (clinical research)

Prognostic factors in patients with glioblastoma multiforme (clinical research)

Circulating miR‐26a and miR‐21 as biomarkers for glioblastoma multiform

Inhibition of tumor formation and redirected differentiation of glioblastoma cells in a xenotypic embryonic environment

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