2013
DOI: 10.1186/1757-2215-6-65
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: BackgroundLei and Spradling in a recent study published in PNAS failed to detect ‘germline cysts’ by elegant studies using lineage tracing approach and thus concluded that adult mouse ovaries lack stem cells. They proposed that primordial follicle pool generated during fetal life is sufficient to sustain oogenesis and that there is no renewal of oocytes during adult life. Contrary to their results, we have reported presence of very small pluripotent, embryonic-like stem cells (VSELs), their immediate descendan… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
27
1

Year Published

2014
2014
2019
2019

Publication Types

Select...
5
2

Relationship

2
5

Authors

Journals

citations
Cited by 37 publications
(28 citation statements)
references
References 28 publications
(49 reference statements)
0
27
1
Order By: Relevance
“…Although the concept of stem cells in adult ovaries is still not well accepted -the conflict appears to be more technical (Bhartiya 2012, Bhartiya et al 2013a) and hopefully will be resolved in due course. In addition to the seminal contributions made by Jonathan Tilly's group in the field, recently equating ovarian stem cells (OSCs) to spermatogonial stem cells (SSCs) in testis , and their protocols to isolate OSCs , our group has reported an additional population of stem cells (VSELs) in both ovary and testis (Bhartiya et al 2010, 2013b, Parte et al 2011, in addition to the OSCs/OGSCs.…”
Section: R41mentioning
confidence: 99%
See 2 more Smart Citations
“…Although the concept of stem cells in adult ovaries is still not well accepted -the conflict appears to be more technical (Bhartiya 2012, Bhartiya et al 2013a) and hopefully will be resolved in due course. In addition to the seminal contributions made by Jonathan Tilly's group in the field, recently equating ovarian stem cells (OSCs) to spermatogonial stem cells (SSCs) in testis , and their protocols to isolate OSCs , our group has reported an additional population of stem cells (VSELs) in both ovary and testis (Bhartiya et al 2010, 2013b, Parte et al 2011, in addition to the OSCs/OGSCs.…”
Section: R41mentioning
confidence: 99%
“…FSHR1 is a G protein-coupled receptor that acts via the cAMP signaling pathway, whereas FSHR3 is a growth factor type I receptor that Neo-oogenesis and primordial follicle assembly Figure 1 Schematic of the hypothesis put forth in the review. Two distinct populations of stem cells exist in OSE including the VSELs with nuclear OCT4 and the immediate descendant OSCs with cytoplasmic OCT4 (Parte et al 2011, 2013a. VSELs undergo selfrenewal and also give rise to the OSCs, which rapidly divide, form germ cell nests, and further differentiate into the oocytes.…”
Section: R37mentioning
confidence: 99%
See 1 more Smart Citation
“…10,13 We have demonstrated similar phenomenon in sheep ovaries 17 and have also published explanations for lack of germ cell cysts observed by others recently. 16 …”
Section: Stem Cells In Adult Mouse Ovarymentioning
confidence: 99%
“…More explanations for existing criticisms against the concept of ovarian stem cells and postnatal oogenesis were recently reviewed. 15,16 Our group has been working in the area of gonadal stem cells, and we have shown that they include 2 distinct populations, namely, the relatively ''quiescent'' very small embryonic-like stem cells (VSELs) and the more committed ''active'' progenitor stem cells, which include ovary germ stem cells (OGSCs) in ovary 2,17 and spermatogonial stem cells in testis. 18 The concept is very similar to the presence of quiescent and active stem cell population proposed in other organs like gut, skin, and bone marrow.…”
Section: Introductionmentioning
confidence: 99%