Ovarian small cell carcinoma of the hypercalcemic type in a 14 month old: The youngest reported case

Florell, Scott R.; Bruggers, Carol S.; Matlak, Michael E.; Young, Robert H.; Lowichik, Amy

doi:10.1002/(sici)1096-911x(199904)32:4<304::aid-mpo13>3.0.co;2-m

Cited by 45 publications

(19 citation statements)

References 7 publications

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“…3,11 Another limited number long-term survivors in stage III disease were treated with a regimen consisting of postoperative induction therapy with BEP followed by consolidation courses of vincristine, actinomycin-D, and cyclophosphamide (VAC) 51 or a regimen consisting of 5 to 6 chemotherapeutic agents (combinations of vinblastine, cisplatin, cyclophosphamide, bleomycin, adriamycin, doxorubucin, and etoposide). 45,48 However, efficacy and efficiency of these regimens in comparison with the BEP regimen remains to be established.…”

Section: Chemotherapymentioning

confidence: 99%

Clinical Management of Ovarian Small-Cell Carcinoma of the Hypercalcemic Type: A Proposal for Conservative Surgery in an Advanced Stage of Disease

Dykgraaf

Jong

Veen

et al. 2009

Int J Gynecol Cancer

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Ovarian small-cell carcinoma of the hypercalcemic type is a rare and highly malignant tumor. In two thirds of the patients, the tumor is associated with asymptomatic paraneoplastic hypercalcemia. The diagnosis may be impeded; the tumor must be distinguished from other tumors with similar features.This tumor occurs predominantly in young women and is merely lethal. The 1-year survival is solely 50%, with an overall 5-year survival rate of approximately 10%. It is believed that the empirical treatment characterized by combination of radical surgery, chemotherapy, and radiotherapy results in the most favorable outcome in terms of survival. However, the outcome remains extremely poor despite this aggressive approach.Alternatively, these poor survival rates may justify a less aggressive fertility sparing approach without compromising the outcome. Such an approach is illustrated by a case report involving a patient with ovarian small-cell carcinoma of the hypercalcemic type, FIGO stage IIIC. A fertility-sparing approach was used, consisting of conservative surgery followed by induction chemotherapy, interval debulking surgery, and local radiotherapy. During follow-up of 60 months, there was no evidence of disease and the normal menstrual cycle resumed.In addition to this case report, histopathological features, different therapeutic modalities, and outcome of ovarian small-cell carcinoma of the hypercalcemic type is reviewed. This report suggests that a fertility-sparing approach may be just as feasible as the generally applied aggressive approach.

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Section: Chemotherapymentioning

confidence: 99%

Clinical Management of Ovarian Small-Cell Carcinoma of the Hypercalcemic Type: A Proposal for Conservative Surgery in an Advanced Stage of Disease

Dykgraaf

Jong

Veen

et al. 2009

Int J Gynecol Cancer

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“…The youngest patient reported to date was a 14-month-old. 10 At 10 and 6 years of age at diagnosis, the patients in the present study are among the youngest reported. Whether tumors derived from preadolescent SCCOHT patients differ clinically or biologically from other SCCOHT tumors is not known.…”

Section: Discussionmentioning

confidence: 53%

Successful Treatment of Preadolescents With Small Cell Carcinoma of the Ovary Hypercalcemic Type

Pressey

Kelly²,

Hawthorne³

2013

Journal of Pediatric Hematology/Oncology

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“…Ce type histologique touche les femmes jeunes entre neuf et 43 ans avec un âge moyen lors du diagnostic de 23,9 ans [2]. L'atteinte la plus précoce répertoriée est celle d'un bébé de 14 mois [10].…”

Section: Discussionunclassified

Carcinome à petites cellules de l'ovaire hypercalcémiant révélé par un épisode de pancréatite aiguë : à propos d'un cas

Bourgain

Acker

Lambaudie

et al. 2005

Gynécologie Obstétrique & Fertilité

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Ovarian small cell carcinoma of the hypercalcemic type in a 14 month old: The youngest reported case

Cited by 45 publications

References 7 publications

Clinical Management of Ovarian Small-Cell Carcinoma of the Hypercalcemic Type: A Proposal for Conservative Surgery in an Advanced Stage of Disease

Clinical Management of Ovarian Small-Cell Carcinoma of the Hypercalcemic Type: A Proposal for Conservative Surgery in an Advanced Stage of Disease

Successful Treatment of Preadolescents With Small Cell Carcinoma of the Ovary Hypercalcemic Type

Carcinome à petites cellules de l'ovaire hypercalcémiant révélé par un épisode de pancréatite aiguë : à propos d'un cas

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