Ovarian Cancer in Children and Adolescents: Treatment and Reproductive Outcomes

Chaopotong, Pattama; Therasakvichya, Suwanit; Leelapatanadit, Chairat; Jaishuen, Atthapon; Kuljarusnont, Sompop

doi:10.7314/apjcp.2015.16.11.4787

Cited by 13 publications

(12 citation statements)

References 10 publications

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“…8 Chaopotong P et al has reported 91% of the tumours were germ cell and 1% dysgerminoma. 9 In our study ruptured tubal pregnancy is seen in 2% and ruptured corpus luteal cyst in 2%. Ruptured ectopic pregnancy was reported by Nkyekyer K, in 43.3% patients and in 8% cases by Wamwana EB et al 6,10 CONCLUSION 50 girls admitted in the hospital were analysed.…”

Section: Discussionsupporting

confidence: 47%

Adolescent gynaecology problems in rural South India: a review of hospital admission in a tertiary care teaching hospital in Ammapettai, Tamil Nadu, India A review of hospital admission in a tertiary care teaching hospital in Ammapettai

Sheelaa¹,

Chellatamizh²,

Mohanamba³

et al. 2017

Int J Reprod Contracept Obstet Gynecol

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Background: Adolescent girl’s knowledge about sexual abuse and awareness of health services is poor. The study is conducted to analyse the gynaecological problems mandating hospitalization and to formulate modalities to improve their health and to ensure safe motherhood. The objectives of this study were to evaluate gynaecological problems in adolescent girls, and to analyse gynaecological emergencies, and to develop modalities to improve adolescent health and for safe motherhood.Methods: Retrospective hospital based observational study of hospital records regarding health issues and awareness of health services among girls in the age group of 13-19 years hospitalized for various medical and surgical problems during the period of January 2015 to January 2016 at Shri Sathya Sai medical college and Research Institute, Ammapettai, Kancheepuram, Tamil Nadu, India. 50 age, education, social background, knowledge of available health services, contraception and detailed history of menstruation regarding duration, quantity and previous medication prior to admission and their present cause of admission were analysed.Results: Total admission in the year were 50, medical 34 (including 5 girls who had check curettage for postabortal bleeding with severe anemia) and surgical 16. Early adolescent group were 34 (68%)and late adolescent group were 16 (32%), married were 5 (10%) and unmarried 45 (90%). All 50 girls were from low socioeconomic class, with rural background. 84% were school dropout and 40% were unemployed. 20 % of our study subjects were admitted with unsafe abortion with postabortal bleeding with no knowledge about Health services.16% were sexually abused and were raped. Abnormal uterine bleeding(menorrhagia) is the most common gynaecological problem in adolescent girls in our study. DUB (52%) is the most common cause. Second most common cause for abnormal bleeding is postabortal bleeding (40%). The most common surgical procedure done was check curettage for postabortal bleeding in 10%. Next common surgery was laparotomy for ovarian cyst in 6% cases and for torsion adnexal cyst in 6%.Conclusions: The most important cause for admission was anemia following abnormal excessive bleeding P/V due to DUB or postabortal bleeding. Second most important cause was ovarian tumours. Unprotected coitus, sex abuse and repeated unsafe abortions have increased the rate of PID and ectopic pregnancies. The study emphasizes the need to sensitize these young girls on the issue like excessive menstruation, gender relationships, and sex abuses. Create awareness and promote knowledge regarding medical issue, available health services and contraception to prevent unsafe abortion and its sequelae. Active implementation of projects like ARSH - adolescent friendly reproductive services, where confidentiality is maintained and proper counseling regarding contraception and supplementation of iron and folic acid is given to all adolescent girls who are future mothers and to ensure safe motherhood.

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Section: Discussionsupporting

confidence: 47%

Adolescent gynaecology problems in rural South India: a review of hospital admission in a tertiary care teaching hospital in Ammapettai, Tamil Nadu, India A review of hospital admission in a tertiary care teaching hospital in Ammapettai

Sheelaa¹,

Chellatamizh²,

Mohanamba³

et al. 2017

Int J Reprod Contracept Obstet Gynecol

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“…Ovarian cancer is the second leading cancer and the 5th leading cause of cancer-related deaths in women. The five-year survival rate of ovarian cancer is only 47% because no sophisticated approach for the early diagnosis makes most ovarian cancers diagnosed at advanced stages [ 14 , 15 ]. To identify novel biomarkers for cancer diagnosis and novel targets for treatment, we observed the effects of ectopic ING5 overexpression on the aggressive phenotypes of ovarian cancer cells, and analyzed the relevant mechanisms.…”

Section: Introductionmentioning

confidence: 99%

The roles of ING5 expression in ovarian carcinogenesis and subsequent progression: a target of gene therapy

Zheng

Zhao

Song³

et al. 2017

Oncotarget

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Here, we found that ING5 overexpression suppressed cell viability, glucose metabolism, migration, invasion and epithelial-mesenchymal transition, and induced cell arrest, apoptosis, senescence, autophagy and fat accumulation in ovarian cancer cells. ING5-mediated chemoresistance was positively linked to apoptotic resistance and chemoresistance-related gene expression. ING5 overexpression suppressed tumor growth of ovarian cancer by decreasing proliferation, and inducing apoptosis and autophagy. ING5 mRNA level was lower in ovarian cancer than normal ovary, and borderline than benign tumors (p < 0.05), and negatively correlated with vascular invasion, lymphatic invasion and FIGO staging of ovarian cancer (p < 0.05). ING5 protein was less expressed in primary cancer than normal ovary (p < 0.05). There was a negative correlation between ING5 mRNA expression and the overall or progression-free survival time of the cancer patients with Grade 2, Grade 3, and stage I cancer (p < 0.05). Immunohistochemically, ING5 was less expressed in serous and mucinous adenocarcinoma than miscellaneous subtypes, and positively correlated with dedifferentiation and ki-67 expression of ovarian cancer (p < 0.05). These data suggested that down-regulated ING5 expression might be involved in ovarian carcinogenesis possibly by suppressing aggressive phenotypes, including proliferation, tumor growth, migration, invasion, and anti-apoptosis.

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“…Our cases are characterized by common premenarchal germ cell tumors and common abdominal pain at presentation similar to other case series [4][5][6][7][8][9]. No documented emergent acute abdomen unlike some reports [10,11].…”

Section: Discussionmentioning

confidence: 60%

“…The current management protocols for germ cell tumors can allow fertility preservation [5]. One of our patients with dysgerminoma got married and delivered a baby.…”

Section: Discussionmentioning

confidence: 99%

Pediatric and Adolescent Malignant Ovarian Tumors: Mansoura 5 - Year Experience

Sarhan¹,

Halim²,

Elzayat³

et al. 2017

JCTI

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Background: Pediatric ovarian tumors are rare. The aim of this work is to study the epidemiological characteristics and treatment outcome of these tumors in our locality. Methods: This retrospective study was performed in accordance with the ethical policies. Between January 2011 to December 2015, Thirteen cases of pediatric ovarian cancers were recorded in the Pediatric Oncology Unit of Oncology Center of Mansoura University and the Clinical Oncology & Nuclear Medicine Department of Mansoura University Hospital. The clinico-epidemiologic data and the treatment protocols were analyzed. Results: The median age was 10 years (range: 2-17). Presenting symptoms were mainly lower abdominal pain (6; 46.2%) and palpable abdominal mass (4; 30.7). Through laparotomy all patients underwent unilateral salpingo-oophorectomy except one case for whom bilateral salpingiooophorectomy was done. Six patients were stage I (46.2%), 2 patients were stage II (15.4%) and 5 patients were stage III tumors (38.4%). The majority had germ cell tumors (11; 85%). Adjuvant chemotherapy was given to all cases. Further chemotherapy was needed in 6 cases due to progression or recurrence. The median follow up was 35 months while the median overall survival was 40 months. Mortality rates were 90% in stages II and III together. The advanced stages and yolk sac pathology had the highest mortality. One of the survived cases got married and delivered a baby. Conclusion: Germ cell tumors are the commonest pediatric malignant ovarian tumors. Multimodality treatment is essential. Fertility preservation should be respected. Our mortality rates are relatively high.

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Ovarian Cancer in Children and Adolescents: Treatment and Reproductive Outcomes

Cited by 13 publications

References 10 publications

Adolescent gynaecology problems in rural South India: a review of hospital admission in a tertiary care teaching hospital in Ammapettai, Tamil Nadu, India A review of hospital admission in a tertiary care teaching hospital in Ammapettai

Adolescent gynaecology problems in rural South India: a review of hospital admission in a tertiary care teaching hospital in Ammapettai, Tamil Nadu, India A review of hospital admission in a tertiary care teaching hospital in Ammapettai

The roles of ING5 expression in ovarian carcinogenesis and subsequent progression: a target of gene therapy

Pediatric and Adolescent Malignant Ovarian Tumors: Mansoura 5 - Year Experience

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