Ovarian aging: an ongoing prospective community-based cohort study in middle-aged Chinese women

Sun, Xiangyu; Luo, Meiling; Ma, Miling; Tang, Ruiyi; Wang, Y; Liu, G; Lin, Shunquan; Chen, R

doi:10.1080/13697137.2018.1458833

Cited by 18 publications

(10 citation statements)

References 32 publications

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“…Finally, there were some differences in BMI, marital status, education, and general health status between the premenopausal women and postmenopausal women at baseline, mainly due to increasing ages. The postmenopausal women at baseline had an earlier menopausal age because they recalled their menopausal age, which could be approximately 1 to 2 years earlier than the real menopausal age, as has been shown by other studies (17,25). However, a repeat analysis excluding women who were postmenopausal at baseline found that the results were not altered, suggesting that any inaccuracies in women's recollection of their menopausal age did not bias the results.…”

Section: Discussionsupporting

confidence: 64%

“…An exchangeable working correlation matrix that accounts for correlations within subjects was used. Because women who were postmenopausal at enrollment (n ¼ 190) may not have recalled their age at menopause accurately due to recall bias (17,25), we repeated the analysis with these women excluded.…”

Section: Discussionmentioning

confidence: 99%

“…The data for this analysis were part of PALM, a prospective, open-cohort, community-based longitudinal study. A detailed description of the PALM cohort and the study procedures has been already been published (17). Briefly, this study was initiated in July 2005.…”

Section: Participantsmentioning

confidence: 99%

“…We analyzed data from the Peking Union Medical College Hospital Aging Longitudinal Cohort of Women in Midlife (PALM), the first longitudinal study of women in midlife in the People's Republic of China (17). Our present study describes the trajectories of anxiety and depressive symptoms in Chinese women and examines the associations between symptoms of anxiety and depression according to the stages of menopause.…”

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confidence: 99%

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Symptoms of anxiety and depression among Chinese women transitioning through menopause: findings from a prospective community-based cohort study

Tang

Luo

et al. 2019

Fertility and Sterility

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Objective: To determine the prevalence of symptoms of anxiety and depression in Chinese women during and after menopause, and the associated risk factors. Design: Prospective community-based cohort study. Setting: An urban community in Beijing, People's Republic of China. Patient(s): Four hundred and thirty women who had transitioned through natural menopause. Intervention(s): None. Main Outcome Measure(s): Symptoms of anxiety and depression. Result(s): Symptoms of depression were more common than symptoms of anxiety. The prevalence of symptoms of depression rose from 14.5% during premenopause, to 18.2% during the menopausal transition, and 19.6% in the postmenopause period. The prevalence of symptoms of anxiety rose from 3.1% premenopause, to 7.0% during the menopausal transition, and 7.4% in the postmenopause period. Compared with women in the premenopausal stage, perimenopausal and postmenopausal women were more likely to have symptoms of anxiety and depression, but these differences were not statistically significant. Multivariable analysis showed that poor health status, trouble falling asleep, and early awakening were independently associated with symptoms of anxiety, and that a higher body mass index, poor health, low education status, and night sweats were independently associated with symptoms of depression. Conclusion(s): Symptoms of depression were more prevalent than symptoms of anxiety. Our findings suggest that symptoms of anxiety and depression are more common during and after menopause than in premenopausal women. These findings highlight the importance of screening and evaluation of women undergoing the menopausal transition for symptoms of anxiety and depression, especially those with risk factors. (Fertil Steril Ò 2019;112:1160-71. Ó2019 by American Society for Reproductive Medicine.) El resumen está disponible en Español al final del artículo.

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Section: Discussionsupporting

confidence: 64%

Section: Discussionmentioning

confidence: 99%

Section: Participantsmentioning

confidence: 99%

mentioning

confidence: 99%

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Symptoms of anxiety and depression among Chinese women transitioning through menopause: findings from a prospective community-based cohort study

Tang

Luo

et al. 2019

Fertility and Sterility

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“…The control group included 111 post-menopausal women. The comparison data is from the PUMCH Aging Longitudinal Cohort of Midlife Women (PALM), a prospective, open-cohort, which involved with a community-based longitudinal study, aiming to investigate ovarian ageing in midlife women in China [ 29 ]. The participants were middle-aged female residents of the TieEr community, Xicheng District, Beijing, China.…”

Section: Methodsmentioning

confidence: 99%

The significance of FMR1 CGG repeats in Chinese women with premature ovarian insufficiency and diminished ovarian reserve

Tang

2020

Reprod Biol Endocrinol

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Background Previous studies have shown that there is an association between FMR1 CGG repeats and ovarian dysfunction. The aim of this study is to assess the association between the number of CGG repeats in FMR1 in Chinese patients with premature ovarian insufficiency (POI) and diminished ovarian reserve (DOR). Methods This is a cross-sectional, case-control study, which enrolled 124 patients with POI, 57 patients with DOR and 111 normal menopausal controls. The demographic details along with other clinical data were recorded. The FMR1 CGG repeats were analyzed by polymerase chain reaction and microfluidic capillary electrophoresis. Results We could detect two premutation carriers in the POI group (1.6%) and one in the control group (0.9%). No premutation carriers were identified in the DOR group. The frequency of FMR1 premutations was not different between POI or DOR and controls. The most common CGG repeat was 29 and 30, and the repeat length for allele 2 had a secondary peak around 36–39 repeats. The CGG repeats were divided into groups of five consecutive values, and the distribution of allele 1 in the POI group was different from that in the control group ( P < 0.001). No statistically significant differences were found for allele 1 between DOR group vs. controls, and for allele 2 between three groups ( P > 0.05). Conclusions The study shows that the frequency of FMR1 premutations is relatively low (1.6%) in Chinese women with POI. The distribution of allele 1 CGG repeat in patients with POI showed difference from that in healthy women.

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Evaluation and Early Warning Systems of Ovarian Aging

et al. 2023

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Ovarian aging: an ongoing prospective community-based cohort study in middle-aged Chinese women

Abstract: This is the first population-based prospective cohort study exploring the ovarian aging process in Chinese women. A large sample size and long follow-up duration were achieved. Detailed analysis of data obtained from this cohort will be provided in future reports.

Cited by 18 publications

References 32 publications

Symptoms of anxiety and depression among Chinese women transitioning through menopause: findings from a prospective community-based cohort study

Symptoms of anxiety and depression among Chinese women transitioning through menopause: findings from a prospective community-based cohort study

The significance of FMR1 CGG repeats in Chinese women with premature ovarian insufficiency and diminished ovarian reserve

Evaluation and Early Warning Systems of Ovarian Aging

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