Outer membrane inflammatory protein A, a new virulence factor involved in the pathogenesis of Helicobacter pylori

Zhang, Jinyong; Qian, Jiajun; Zhang, Xiaoli; Zou, Quanming

doi:10.1007/s11033-014-3673-9

Cited by 20 publications

(13 citation statements)

References 48 publications

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“…The viability of H. pylori on the surface of the gastrointestinal mucosa depends on its colonization factors such as urease, motility, chemotaxis, outer membrane proteins, and the special helix morphology of the bacterium [15, 44, 53, 78, 85]. The optimal pH of H. pylori is neutral [28, 76], while the optimal pH of H. pylori in liquid media is 8.5 (slightly alkaline) [4].…”

Section: Functions and Pathogenicity Of H Pylori Flagellamentioning

confidence: 99%

Role of Flagella in the Pathogenesis of Helicobacter pylori

2017

Curr Microbiol

119

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This review aimed to investigate the role of Helicobacter pylori flagella on the pathogenicity of this bacterium in humans. Helicobacter pylori is a flagellated pathogen that colonizes the human gastroduodenal mucosa and produces inflammation, and is responsible for gastrointestinal disease. Its pathogenesis is attributed to colonization and virulence factors. The primary function of H. pylori flagella is to provide motility. We believe that H. pylori flagella play an important role in the colonization of the gastrointestinal mucosa. Therefore, we reviewed previous studies on flagellar morphology and motility in order to explore the relationship between H. pylori flagella and pathogenicity. Further investigation is required to confirm the association between flagella and pathogenicity in H. pylori.

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Section: Functions and Pathogenicity Of H Pylori Flagellamentioning

confidence: 99%

Role of Flagella in the Pathogenesis of Helicobacter pylori

2017

Curr Microbiol

119

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“…SSM is one of the mechanisms resulting in the phase variation that produces nucleotide mispairing between the mother and daughter strand during the DNA replication[87,88]. The OMP genes such as babB, hopZ, oipA that possess the dinucleotide CT-repeats in the 5’-coding region, likely undergo SSM to regulate their expression by phase variation[18,89,90]. Nucleotide slippage can be occurred in replicating or template strand.…”

Section: Literature Searchmentioning

confidence: 99%

Helicobacter pyloriBabA in adaptation for gastric colonization

Ansari

Yamaoka

2017

WJG

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Helicobacter pylori (H. pylori) as a causative agent of gastric complications, is well adapted for the colonization of gastric mucosa. Although the infectious process depends on several factors, the adhesion to the gastric mucosa is the first and important step. Among several outer membrane proteins, BabA is one of the significant protein involving in many inflammatory processes in addition to its role in the attachment for the persistent colonization. We performed a PubMed search using the key words: “babA”, “pylori”, “gastric complications”, “homologous recombination”, “slipped strand mispairing”; a total of 249 articles were displayed. Of these we mainly focused on articles with the full text in English and published between 2005 and 2016. H. pylori BabA is involved in binding with receptors; however, its synthesis is regulated by phase variation. In this review we confirm that H. pylori babA can be modulated at the molecular and functional levels to adapt to the stress within the gastro-intestinal tract.

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“…H. pylori adhesins are reported to be virulence factors involved in processes during the early and chronic phases of infection for both colonization and pathogenesis3. AlpA, OipA, BabA, and SabA bind, respectively, to laminin, EGFR, fucosylated Lewis b blood group antigens, and sialylated carbohydrates on the surface of gastric epithelial cells, and play roles in the bacterial colonization of the gastric mucosa333435. In our study, we found that the number of bacteria attached to each gastric epithelial cell was considerably higher for GC strain H. pylori, which shows higher expression of these adhesins, than for DU strain H. pylori.…”

Section: Discussionmentioning

confidence: 99%

“…It is well recognized that the release of proinflammatory cytokines is closely linked to the pathogenesis of H. pylori -associated gastric cancer3738. Among the adhesins, AlpA, OipA, and BabA are known to induce IL-8 secretion by gastric epithelial cell lines34394041. The role of these adhesins in inflammation shows that they may be important not only in colonization by helping H. pylori adhere to host cells, but also in H. pylori- associated gastric carcinogenesis by being involved in immune response induction6.…”

Section: Discussionmentioning

confidence: 99%

Combination of OipA, BabA, and SabA as candidate biomarkers for predicting Helicobacter pylori-related gastric cancer

Huang

et al. 2016

Sci Rep

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Helicobacter pylori (H. pylori ) infection is a major cause of chronic gastritis and is highly related to duodenal ulcer (DU) and gastric cancer (GC). To identify H. pylori-related GC biomarkers with high seropositivity in GC patients, differences in levels of protein expression between H. pylori from GC and DU patients were analyzed by isobaric tag for relative and absolute quantitation (iTRAQ). In total, 99 proteins showed increased expression (>1.5-fold) in GC patients compared to DU patients, and 40 of these proteins were categorized by KEGG pathway. The four human disease-related adhesin identified, AlpA, OipA, BabA, and SabA, were potential GC-related antigens, with a higher seropositivity in GC patients (n = 76) than in non-GC patients (n = 100). Discrimination between GC and non-GC patients was improved using multiple antigens, with an odds ratio of 9.16 (95% CI, 2.99–28.07; p < 0.0001) for three antigens recognized. The optimized combination of OipA, BabA, and SabA gave a 77.3% correct prediction rate. A GC-related protein microarray was further developed using these antigens. The combination of OipA, BabA, and SabA showed significant improvement in the diagnostic accuracy and the protein microarray containing above antigens should provide a rapid and convenient diagnosis of H. pylori-associated GC.

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Outer membrane inflammatory protein A, a new virulence factor involved in the pathogenesis of Helicobacter pylori

Cited by 20 publications

References 48 publications

Role of Flagella in the Pathogenesis of Helicobacter pylori

Role of Flagella in the Pathogenesis of Helicobacter pylori

Helicobacter pyloriBabA in adaptation for gastric colonization

Combination of OipA, BabA, and SabA as candidate biomarkers for predicting Helicobacter pylori-related gastric cancer

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