Outcomes of primary liver cancer in children: an appraisal of experience

Pham, Tuan H.; Iqbal, Corey W.; Grams, Jayleen; Zarroug, Abdalla E.; Wall, Jarrod C.H.; Ishitani, Michael B.; Nagorney, David M.; Moir, Christopher R.

doi:10.1016/j.jpedsurg.2006.12.065

Cited by 54 publications

(40 citation statements)

References 24 publications

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“…10,17 This benefit has been observed especially in HBL as collaborative study groups have determined optimal chemotherapy regimens that are timed to coincide with surgical treatment. 3,18 To avoid tumor progression and metastases, patients with HBL are now considered to have 1b status (UNOS designation for transplant) at the initial listing as opposed to waiting 30 days at a Model for End-Stage Liver Disease/ Pediatric End-Stage Liver Disease model score of 30.…”

Section: Discussionmentioning

confidence: 99%

Effect of Liver Transplant on Long-term Disease-Free Survival in Children With Hepatoblastoma and Hepatocellular Cancer

et al. 2015

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Section: Discussionmentioning

confidence: 99%

Effect of Liver Transplant on Long-term Disease-Free Survival in Children With Hepatoblastoma and Hepatocellular Cancer

et al. 2015

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“…Today, the achievement of a complete surgical resection is the most important factor determining outcome in patients with hepatoblastoma [2][3][4]. Chemotherapy has consistently resulted in improved resectability and survival [11][12][13].…”

Section: Discussionmentioning

confidence: 99%

“…Even then, the incidence is only around one child per million per year in the UK [1]. The treatment of hepatoblastoma has always centered on a complete surgical resection in order to achieve long-term survival [2][3][4]. The introduction of chemotherapy in the neoadjuvant setting has further helped improve surgical resection rates [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Hepatoblastoma: a single institutional experience of 18 cases

et al. 2008

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Hepatoblastomas are the most common liver tumours in children. However, they are rare as compared to other solid malignancies. Thus, there is a need to integrate data from surgical centers around the world to provide a clearer view on the outcomes of multidisciplinary management of these tumours. We set out to retrospectively review our experience of patients with surgically resected hepatoblastomas looking at primary and secondary outcomes. Children diagnosed with hepatoblastoma and managed surgically (along with chemotherapy) at a single institution between 1 January 2000 and 31 May 2007, were analyzed. Out of the 18 patients, there were 12 male and 6 female patients. The median age was 18 months (range 8-72). A palpable mass in abdomen was the presenting symptom in 88% patients. Sixteen patients (88.8%) underwent major liver resection. Sixteen patients (88.8%) received preoperative chemotherapy. Complete gross resection (stage I and II) was achieved in all 18 patients (100%). The mortality and morbidity rates were 0 and 11.2%, respectively. The 80-month disease-free survival was 67%. This series, the largest from India in terms of surgical resections for hepatoblastoma, reaffirms that major liver resection can be performed with minimal perioperative mortality and morbidity and that the use of chemotherapy has definitely helped in down staging tumours for liver resection.

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“…The foundation of HB management is surgical resection [89] and preoperative chemotherapy could cause the tumor to shrink, allowing removal of a previously unresectable tumor [90,91]. Liver transplantation for HB also has been recommended [92].…”

Section: Hepatoblastomamentioning

confidence: 99%