Outcomes of Preinjury Use of Statins in Patients with Traumatic Brain Injury: A Systematic Review and Meta-analysis

The neuroprotective effect of statin in traumatic brain injury: A systematic review

“… 13 , 14 In their meta-analysis, Mu et al also emphasized statin discontinuation was linked to an increase in mortality. 3 …”

“…In their meta-analysis, Mu et al demonstrated that pre-TBI statin use was linked to a lower risk of mortality in TBI individuals compared to nonusers. 3 Lokhandwala et al revealed that pre-TBI usage of statins had a decreased in-hospital mortality rate, skilled nursing facility disposition, and a higher median GOS-extended. 6 Schneider et al researched the association between pre-TBI statin use survival and functional recovery in older moderate to severe TBI individuals, revealed that statin usage was related to a 76% reduced adjusted risk of in-hospital death, 76.7% of those discharged alive survived 1 year, and 66.8% had full GOS-extended, additionally, statin users had a 13% greater chance of excellent recovery 12 months after injury.…”

“… Author Year Title Study Design Sample Result Authors' Conclusion Shafiee et al 2 2021 The Effect of Oral Simvastatin on the Clinical Outcome of Patients with Severe Traumatic Brain Injury: A Randomized Clinical Trial Randomized controlled trial 98 ✓ Simvastatin may be an effective and promising therapeutic modality for improving GCS score during TBI recovery. Mu et al 3 2021 Outcomes of Preinjury Use of Statins in Patients with Traumatic Brain Injury: A Systematic Review and Meta-analysis Systematic review and meta-analysis 111.395 (of 7 trials) ✓ Preinjury statin use may contribute to mortality reduction in patients with TBI, whereas statin withdrawal might increase mortality. In clinical management, statin use should not be discontinued after TBI.…”

“…2 To ameliorate the outcomes of TBI, no entirely efficacious pharmacotherapies have been developed. 3 …”

Role of statins in regulating molecular pathways following traumatic brain injury: A system pharmacology study

“…previous studies, despite statins mainly influencing lipid-related genes, they might impact various genes involved in inflammation, apoptosis, and oxidative stress [43][44][45]. A systematic meta-analysis reported that statins might contribute to decreasing death, whereas stopping consumption might boost mortality [46]. Numerous preclinical and clinical research was accomplished to survey the impact of statins on TBI.…”