Outcomes of Mild Cognitive Impairment by Definition

Neuropsychological Criteria for Mild Cognitive Impairment and Dementia Risk in the Framingham Heart Study

“…Progression to dementia by the single domain non-amnestic subtype was also similar for both criteria (Petersen/Winblad HR=2.50; p -value=.02; Jak/Bondi HR=2.56; p -value=.05). Unlike prior studies highlighting the instability of the single domain non-amnestic MCI subtype (Ganguli et al, 2011), we found an association between single domain non-amnestic MCI and incident dementia for both criteria.…”

Neuropsychological Criteria for Mild Cognitive Impairment and Dementia Risk in the Framingham Heart Study

“…Progression to dementia by the single domain non-amnestic subtype was also similar for both criteria (Petersen/Winblad HR=2.50; p -value=.02; Jak/Bondi HR=2.56; p -value=.05). Unlike prior studies highlighting the instability of the single domain non-amnestic MCI subtype (Ganguli et al, 2011), we found an association between single domain non-amnestic MCI and incident dementia for both criteria.…”

Health-Related Predictors of Changes in Cognitive Status in Community-Dwelling Older Individuals

“…As concerns MCI, the rate of progression to dementia was 4%, while 10% reverted to PCH, and 12% became unclassifiable at the follow-up assessment. This picture is in line with findings published previously (Di Carlo et al, 2007 ; Ganguli et al, 2011 ). Indeed, the estimates for MCI reversion rates ranged from 8% in clinical-based studies to 25% in population-based ones (Canevelli et al, 2016 ), while annual rates were ~5–10% for MCI progression to dementia (Mitchell and Shiri-Feshki, 2009 ).…”

Factors Predicting Reversion from Mild Cognitive Impairment to Normal Cognitive Functioning: A Population-Based Study

“…Our finding that individuals with multiple-domain MCI are less likely than those with single-domain MCI to revert to normal cognition is consistent both with previous reports [3], [13], [15]–[18] and with findings that multiple-domain MCI is more likely to transition to AD, which we have previously reported [38]. We also found that individuals with moderate or severe impairment in any one domain were less likely to revert.…”

Neuropsychological Criteria for Mild Cognitive Impairment and Dementia Risk in the Framingham Heart Study

“…Progression to dementia by the single domain non-amnestic subtype was also similar for both criteria (Petersen/Winblad HR=2.50; p -value=.02; Jak/Bondi HR=2.56; p -value=.05). Unlike prior studies highlighting the instability of the single domain non-amnestic MCI subtype (Ganguli et al, 2011), we found an association between single domain non-amnestic MCI and incident dementia for both criteria.…”

Health-Related Predictors of Changes in Cognitive Status in Community-Dwelling Older Individuals

“…As concerns MCI, the rate of progression to dementia was 4%, while 10% reverted to PCH, and 12% became unclassifiable at the follow-up assessment. This picture is in line with findings published previously (Di Carlo et al, 2007 ; Ganguli et al, 2011 ). Indeed, the estimates for MCI reversion rates ranged from 8% in clinical-based studies to 25% in population-based ones (Canevelli et al, 2016 ), while annual rates were ~5–10% for MCI progression to dementia (Mitchell and Shiri-Feshki, 2009 ).…”

Factors Predicting Reversion from Mild Cognitive Impairment to Normal Cognitive Functioning: A Population-Based Study

“…Our finding that individuals with multiple-domain MCI are less likely than those with single-domain MCI to revert to normal cognition is consistent both with previous reports [3], [13], [15]–[18] and with findings that multiple-domain MCI is more likely to transition to AD, which we have previously reported [38]. We also found that individuals with moderate or severe impairment in any one domain were less likely to revert.…”

Neuropsychological Criteria for Mild Cognitive Impairment and Dementia Risk in the Framingham Heart Study

“…Progression to dementia by the single domain non-amnestic subtype was also similar for both criteria (Petersen/Winblad HR=2.50; p -value=.02; Jak/Bondi HR=2.56; p -value=.05). Unlike prior studies highlighting the instability of the single domain non-amnestic MCI subtype (Ganguli et al, 2011), we found an association between single domain non-amnestic MCI and incident dementia for both criteria.…”

Health-Related Predictors of Changes in Cognitive Status in Community-Dwelling Older Individuals

“…As concerns MCI, the rate of progression to dementia was 4%, while 10% reverted to PCH, and 12% became unclassifiable at the follow-up assessment. This picture is in line with findings published previously (Di Carlo et al, 2007 ; Ganguli et al, 2011 ). Indeed, the estimates for MCI reversion rates ranged from 8% in clinical-based studies to 25% in population-based ones (Canevelli et al, 2016 ), while annual rates were ~5–10% for MCI progression to dementia (Mitchell and Shiri-Feshki, 2009 ).…”

Factors Predicting Reversion from Mild Cognitive Impairment to Normal Cognitive Functioning: A Population-Based Study

“…Our finding that individuals with multiple-domain MCI are less likely than those with single-domain MCI to revert to normal cognition is consistent both with previous reports [3], [13], [15]–[18] and with findings that multiple-domain MCI is more likely to transition to AD, which we have previously reported [38]. We also found that individuals with moderate or severe impairment in any one domain were less likely to revert.…”