Outcomes of endoscopic ultrasound‐guided pancreatic <scp>FNAC</scp> diagnosis for solid and cystic lesions at Manchester Royal Infirmary based upon the Papanicolaou Society of Cytopathology pancreaticobiliary terminology classification scheme

Wright, Peter V.; Shelton, David; Holbrook, Miles; Thiryayi, S. A.; Narine, Nadira; Slater, D.N.; Rana, Durgesh

doi:10.1111/cyt.12502

Cited by 26 publications

(58 citation statements)

References 30 publications

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“…One of the most egregious results in the study was the high rate of inadequacy in specimens. The nondiagnostic rate of 21.2% is higher than rates reported by other authors, ranging from 3.8%‐11.7% 9‐12 . The explanation is multifactorial.…”

Section: Discussionmentioning

confidence: 57%

The benefits of the Papanicolaou Society of Cytopathology System for reporting pancreatobiliary cytology: A 2‐year review from a single academic institution

et al. 2021

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Objective Endoscopic ultrasound‐guided fine needle aspiration (EUS‐FNA) is an essential tool in the diagnosis of pancreatic lesions. The aim of this study was to evaluate the diagnostic accuracy of cytology from EUS‐FNA, to correlate the results with the corresponding histopathological diagnoses and to analyse the impact of retrospective assignment of the Papanicolaou Society of Cytopathology (PSC) reporting system categories. Methods All pancreatic FNA specimens reported at the Royal Free Hospital during a 2‐year period were retrospectively collected and assigned to the PSC system categories. Any available corresponding histological samples were assessed for concordance. Results In total, 236 cytology specimens from 223 patients were identified, of which 108 (45.8%) had corresponding histology samples. The main reason for cyto‐histological discrepancy was sampling error. Interpretive error was identified in one case. Overall, sensitivity was 92.5%, specificity was 100%, diagnostic accuracy of cytology was 95%, false‐positive rate was 0% and false‐negative rate was 7.5%. The implementation of the new reporting system reduced the number of cases in the atypical category. All cases previously categorised as suspicious or malignant remained in the same category. Conclusions EUS‐FNA is an accurate method for evaluating pancreatobiliary lesions. The implementation of the Papanicolaou Society of Cytopathology diagnostic system enhances standardisation of the reporting terminology and reduces the number of samples in the non‐standardised and equivocal atypical category.

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Section: Discussionmentioning

confidence: 57%

The benefits of the Papanicolaou Society of Cytopathology System for reporting pancreatobiliary cytology: A 2‐year review from a single academic institution

et al. 2021

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“…In spite of an accurate correlation in these cases, an attempt to use these data to suggest a high accuracy of pancreatic FNA involving all the PSC categories would be inappropriate based on the current study because of a low proportion of cases with available follow‐up. Wright et al 19 used PSC to categorise 120 samples. Although they had histopathology results in only 20 of these cases, clinical follow‐up data were available in 112 of cases.…”

Section: Discussionmentioning

confidence: 99%

The applicability of Papanicolaou Society of Cytopathology system on reporting endoscopic ultrasound‐guided fine needle aspiration cytology specimens of pancreatic lesions in situations with limited availability of ancillary tests. Experience at a single laboratory

et al. 2020

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Introduction : The Papanicolaou Society of Cytopathology (PSC) system of reporting pancreatobiliary cytology is a standardised reporting nomenclature that uses a six-tiered scheme of diagnostic categories utilising routine microscopy and ancillary tests such as biochemical and molecular analysis of cyst fluids and immunochemistry. The objective of this study was to determine the applicability of the PSC system on endoscopic ultrasound-guided fine needle aspiration cytology samples reported at the cytopathology laboratory, Mubarak Al Kabeer Hospital, in Kuwait with special emphasis on situations with limited availability of ancillary tests. Methods: In total, 132 cases of endoscopic ultrasound-guided fine needle aspiration cytology samples from pancreatic lesions were categorised according to PSC system guidelines after examining the glass slides and reviewing the clinical, imaging and ancillary test findings. These review diagnoses were compared with the diagnoses rendered during initial reporting. Correlation with histopathology reports was done wherever available. Results: In 23 (17.42%) of 132 cases, re-categorisation was necessary between initial and reviewed diagnoses. In 16 cases, re-categorisations were because of nonanalogous categories between initial and reviewed diagnosis. In the remaining seven, they were due to identification of newer cytomorphological and imaging findings or because of issues arising from unavailability of sufficient material for ancillary investigations. Conclusion: All cases could be categorised using the PSC system with a moderate number of re-categorisations between initial and reviewed diagnoses. In certain circumstances, limited availability of ancillary tests, resulted in non-diagnostic | 565 MALLIK et AL. How to cite this article: Mallik MK, Qadan LR, Al Naseer A, et al. The applicability of Papanicolaou Society of Cytopathology system on reporting endoscopic ultrasound-guided fine needle aspiration cytology specimens of pancreatic lesions in situations with limited availability of ancillary tests. Experience at a single laboratory.

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“…The distribution of the cases using the PB system from studies looking at pancreatic FNA specimens places most cases in the negative for malignancy and malignant categories [2][3][4][5][6][7][8][9] (Table 1). In fact, one of the clear benefits of implementing the PB System is the ability to decrease the number of indeterminate interpretations (eg, atypical and nondiagnostic).…”

Section: Experience With the Use Of The Pb System Worldwidementioning

confidence: 99%

Experience and future perspectives on the use of the Papanicolaou Society of Cytopathology Terminology System for reporting pancreaticobiliary cytology

Saieg

Pitman

2020

Diagnostic Cytopathology

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The Papanicolaou Society of Cytopathology developed a set of guidelines for reporting pancreaticobiliary cytology in 2014 (PB System), with a six‐tiered system: Nondiagnostic, Negative, Atypical, Neoplastic (Benign or Other), Suspicious, and Positive. This proposed scheme incorporates ancillary testing such as biochemical testing of cyst fluids for diagnosis and provides terminology that standardizes the category of the various diseases of the pancreas, some of which are difficult to diagnose specifically by cytology alone. Since its initial publication five and half years ago, several groups have published their experiences on the use of the PB System and have shown that most objectives proposed by the original publication have been achieved. They have shown that there is a better understanding and definition of the diagnostic categories with an associated distribution and risk of malignancy. The diagnostic categories of Neoplastic: Other, Suspicious, and Malignant show a high sensitivity and specificity for the diagnosis of malignancy. The System also provides a multi‐specialist view of pancreatic lesions, with biochemical and radiological findings being incorporated into the final pathological report. The present review summarizes these findings and discusses the future perspectives and foreseen changes that are to be incorporated to a second edition of the reporting System.

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Outcomes of endoscopic ultrasound‐guided pancreatic FNAC diagnosis for solid and cystic lesions at Manchester Royal Infirmary based upon the Papanicolaou Society of Cytopathology pancreaticobiliary terminology classification scheme

Cited by 26 publications

References 30 publications

The benefits of the Papanicolaou Society of Cytopathology System for reporting pancreatobiliary cytology: A 2‐year review from a single academic institution

The benefits of the Papanicolaou Society of Cytopathology System for reporting pancreatobiliary cytology: A 2‐year review from a single academic institution

The applicability of Papanicolaou Society of Cytopathology system on reporting endoscopic ultrasound‐guided fine needle aspiration cytology specimens of pancreatic lesions in situations with limited availability of ancillary tests. Experience at a single laboratory

Experience and future perspectives on the use of the Papanicolaou Society of Cytopathology Terminology System for reporting pancreaticobiliary cytology

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