Outcomes of cryosurgery in keloids and hypertrophic scars. A prospective consecutive trial of case series

Zouboulis, Ch.C.

doi:10.1001/archderm.129.9.1146

Cited by 71 publications

(89 citation statements)

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“…Success rates in studies in which contact or spray cryosurgery with liquid nitrogen was used varied between 32% and 74% after two or more sessions, with higher response rates of hypertrophic scars compared with keloids (83,115,116). The usefulness of cryotherapy, however, is limited to the management of small scars.…”

Section: Current Treatment Strategiesmentioning

confidence: 99%

“…The usefulness of cryotherapy, however, is limited to the management of small scars. A delay of several weeks between sessions is usually required for postoperative healing, and the commonly occurring side effects, including permanent hypoand hyperpigmentation, moderate skin atrophy, blistering and postoperative pain, are major handicaps (5,116). Recently, the intralesional-needle cryoprobe method has been assessed in the treatment of hypertrophic scars and keloids (117), and has been demonstrated to have increased efficacy compared with that obtained with contact/ spray probes and shorter reepithelialization periods (117).…”

Section: Current Treatment Strategiesmentioning

confidence: 99%

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Hypertrophic Scarring and Keloids: Pathomechanisms and Current and Emerging Treatment Strategies

Gauglitz

Körting

Pavicic

et al. 2010

Mol Med

1,141

1,012

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Excessive scars form as a result of aberrations of physiologic wound healing and may arise following any insult to the deep dermis. By causing pain, pruritus and contractures, excessive scarring significantly affects the patient's quality of life, both physically and psychologically. Multiple studies on hypertrophic scar and keloid formation have been conducted for decades and have led to a plethora of therapeutic strategies to prevent or attenuate excessive scar formation. However, most therapeutic approaches remain clinically unsatisfactory, most likely owing to poor understanding of the complex mechanisms underlying the processes of scarring and wound contraction. In this review we summarize the current understanding of the pathophysiology underlying keloid and hypertrophic scar formation and discuss established treatments and novel therapeutic strategies.

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Section: Current Treatment Strategiesmentioning

confidence: 99%

Section: Current Treatment Strategiesmentioning

confidence: 99%

Hypertrophic Scarring and Keloids: Pathomechanisms and Current and Emerging Treatment Strategies

Gauglitz

Körting

Pavicic

et al. 2010

Mol Med

1,141

1,012

View full text Add to dashboard Cite

show abstract

“…Cryosurgery and intralesional corticosteroids have been claimed as the mainstream of therapy; the long-term use of corticosteroids has been associated with unacceptable side effects. Cryosurgery may lead to permanent depigmentation, which may be more worrisome for dark-skinned patients than the original problem [3]. To avoid too much depigmentation, we and others have successfully tried intralesional cryosurgery [1, 4], which is a more invasive procedure and thus probably suitable for large keloid lesions.…”

Section: Introductionmentioning

confidence: 99%

Efficacy and Safety of Intralesional 5-Fluorouracil in the Treatment of Keloids

Gupta

Kalra²

2002

Dermatology

184

109

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Background: The treatment of keloids remains challenging. Cryosurgery and intralesional corticosteroids have been considered as the mainstream of therapy; however, the long-term use of corticosteroids has been found to be associated with serious side effects. Intralesional 5-fluorouracil (5-FU) has only been used in one study for the treatment of hypertrophic scars and keloids, mostly in combination with other treatments. The efficacy of 5-FU as an individual therapeutic agent is unknown. Objective: To evaluate the efficacy and safety of intralesional injections of 5-FU in the treatment of small keloid lesions. Methods: Twenty-four (12 male, 12 female) consecutive patients with keloids of 6 cm or less in their maximum dimension were treated with intralesional injections of 50–150 mg 5-FU per week for a maximum of 16 injections. Results: One third (8/24, 33.3%) of the patients showed more than 75% flattening of the keloid. Three out of 8 patients (with >75% flattening) required less than 16 (13, 13 and 15) injections for achieving the desired response. Overall, about half of the patients showed more than 50% flattening of the treated keloid. A correlation with the duration of keloid was found. Six (54.5%) out of 11 patients with keloids of ≤5 years duration, in contrast to only 2 (15.4%) out of 13 patients with keloids of >5 years duration showed more than 75% flattening (p < 0.05). Side effects included pain (all patients), hyperpigmentation (all patients) and ulceration (1 patient). No difference in peripheral blood count was noted before, during and after the therapy. Conclusion: Intralesional 5-FU can be safely used for the management of small keloids of shorter duration.

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“…Many treatments such as use of intralesional corticosteroids, excision, pressure therapy, radiotherapy, cryotherapy, and carbon dioxide laser ablation have been tried with limited success. [5][6][7] Results of more recent studies show the 585-nm flashlamppumped pulsed-dye laser (FLPDL) [8][9][10][11][12] and silicone gel sheeting (SGS) [13][14][15][16][17][18][19][20][21][22][23][24][25][26] to be effective in hypertrophic scar therapy. However, few studies were masked or well controlled.…”

mentioning

confidence: 99%

Prospective, Single-blind, Randomized, Controlled Study to Assess the Efficacy of the 585-nm Flashlamp-Pumped Pulsed-Dye Laser and Silicone Gel Sheeting in Hypertrophic Scar Treatment

Wittenberg¹,

B²,

Bogomilsky³

et al. 1999

Arch Dermatol

121

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Outcomes of cryosurgery in keloids and hypertrophic scars. A prospective consecutive trial of case series

Cited by 71 publications

References 0 publications

Hypertrophic Scarring and Keloids: Pathomechanisms and Current and Emerging Treatment Strategies

Hypertrophic Scarring and Keloids: Pathomechanisms and Current and Emerging Treatment Strategies

Efficacy and Safety of Intralesional 5-Fluorouracil in the Treatment of Keloids

Prospective, Single-blind, Randomized, Controlled Study to Assess the Efficacy of the 585-nm Flashlamp-Pumped Pulsed-Dye Laser and Silicone Gel Sheeting in Hypertrophic Scar Treatment

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