Outcomes of adults with restrictive cardiomyopathy after heart transplantation

Restrictive cardiomyopathy: A review of literature on clinical status and meta-analysis of diagnosis and clinical management

“…It reverses elevated pulmonary vascular resistance and improved survival on radiation-induced RCM. However, cardiac transplantation is not universal and mainly contra-indicated in some cohorts of RCM patients such as amyloid-induced RCM, and suffers the disadvantage of donor shortage, high infection rates and malignancies [107,108]. Besides cardiac transplantation, device therapy such as LV assist devices and mechanical circulatory support have been indicated for RCM patients [111,112].…”

“…Moreover, RCM has one of the leading recorded rates of sudden cardiac death of up to 70% in the fifth year in diagnosed cardiomyopathies [45]. The development of surgical treatment approaches using either device therapy or cardiac transplantation could improve long-term survival rates for RCM patients [105][106][107]. However, surgical treatment has important limitations such as contraindication RCM secondary to systemic diseases such as amyloidosis, and has procedural complication, reducing their effectiveness in the long-term.…”

“…After screening, titles, abstracts and full article against the inclusion criteria, eight (8) studies were included [105][106][107][108][109][110][111][112] published between 2002 and 2016. In total, the eight studies recruited 87,410 patients.…”

“…The main clinical endpoints assessed were elevated pulmonary vascular resistance [105], length of hospital stay [106], survival rates [105,111], mortality rates [105], and post-transplant survival rates [108][109][110]. A majority of the studies investigated long-term outcomes of surgical procedures particularly cardiac transplantation (CTx) [105][106][107][108][109][110] and mechanical circulatory support, and right or left ventricular assist device [111,112]. Cardiac transplantation has been demonstrated to have beneficial effect on 1-5 year survival rates of 40-89.5% on patients with RCM.…”

“…Cardiac transplantation has been demonstrated to have beneficial effect on 1-5 year survival rates of 40-89.5% on patients with RCM. However, patients with RCM due to radiation [106,108,111] or amyloidosis [107,109] have poorer outcomes suggesting the need to consider genetic or idiopathic RCM for cardiac transplantation due to shortages and long wait times for donors. However, patient selection and aggressive therapies to reduce amyloid depositions on myocardial tissues suggest improvement of short-term (380 days) survival rates [110].…”