Outcomes in intermediate-risk squamous cell carcinomas treated with Mohs micrographic surgery compared with wide local excision

Xiong, David D.; Beal, Brandon T.; Varra, Vamsi; Rodríguez, M.A.; Cundall, Hannah L; Woody, N.M.; Vidimos, Allison; Koyfman, Shlomo A.; Knackstedt, Thomas

doi:10.1016/j.jaad.2019.12.049

Cited by 28 publications

(23 citation statements)

References 21 publications

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“…MMS with standard H&E provides 98% to 99% cure rates for primary cSCC with zero (T1) to one (T2a) high-risk features based on Brigham and Women's Hospital staging. 3 Local recurrence rates for high-risk cSCC treated with MMS range between 4% (AJCC8 T3) and 6% (Brigham and Women's Hospital staging T2b/3). 4 However, PCK utilization rate during MMS is unknown, and data on patient outcomes for cSCC treated with MMS plus PCK is lacking.…”

Section: Discussionmentioning

confidence: 99%

Identifying squamous cell carcinoma and cytokeratin-derived amyloid with pan-cytokeratin AE1/AE3 during Mohs micrographic surgery

2020

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Section: Discussionmentioning

confidence: 99%

Identifying squamous cell carcinoma and cytokeratin-derived amyloid with pan-cytokeratin AE1/AE3 during Mohs micrographic surgery

2020

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“…Other surgical modalities like Moh's surgery, curettage, or cryosurgery are not recommended for Marjolin's ulcer by many reports because of the high incidence of deep tumour invasion. 15 , 50 , 51 On the other hand, Copcu's study for small lesions, less than 2 cm, presented 31 cases managed by Moh's micrographic surgery that showed a 92% cure rate. 20 , 34 However, Moh's surgery has drawbacks of relatively prolonged surgical time, and unfeasibility of its facilities or experts in every centre.…”

Section: Discussionmentioning

confidence: 99%

Post‐burn scar malignancy: 5‐year management review and experience

Mousa

Elshenawy

Maklad

et al. 2021

International Wound Journal

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The study spotlights a severe uncommon post-burn complication, Marjolin's ulcer, in upper Egypt plastic and wound care centres. This problem is mainly related to inadequate medical care and awareness. No community or race is immune. The underlying malignant transformation mechanism remains unclear. The study aims, according to our experience, to review the prognostic factors through the management protocol of Marjolin's ulcers. This prospective study was conducted in the Aswan University Plastic & Burn surgery department in South Egypt between 2013 and 2020 and investigated 226 patients with chronic post-burn ulceration. Nineteen cases were proved to have Marjolin's

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“…In their study, the LRR was 2.6% in patients with primary SCC and 5.9% in patients with previously recurrent SCC [ 54 ]. Xiong et al conducted a retrospective study evaluating the outcomes of patients with T2a SCC who were treated with WLE or MMS [ 55 ]. They found that the LRR was significantly higher in those treated with WLE (4.0%) than in those treated with MMS (1.2%).…”

Section: Surgical Margin Of Primary Tumorsmentioning

confidence: 99%

Evidence from Clinical Studies Related to Dermatologic Surgeries for Skin Cancer

Ishizuki

Nakamura

2022

Cancers

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Despite the significant progress made in the past several years in pharmacotherapies for skin cancer, such as BRAF/MEK inhibitors, immune checkpoint inhibitors, and Hedgehog pathway inhibitors, surgical removal of primary skin cancer is still the first choice of treatment unless distant metastases are evident. In cases of lymph node metastases with clinically palpable lymphadenopathy, lymph node dissection (LND) is typically performed for most skin cancers. In the surgical treatment of primary skin tumors, the surgical margin is critical not only for reducing the possibility of tumor recurrence but also for minimizing the cosmetic and functional complications associated with wide local excision. In contrast, dermatologic surgery can cause various complications. Although skin graft is frequently used for reconstruction of the surgical defect, extensive graft necrosis may develop if optimal stabilization of the graft is not obtained. LND also sometimes causes complications such as intraoperative or postoperative bleeding and postoperative lymphoceles. Moreover, as in other types of surgery, surgical site infection, intraoperative anxiety, and intraoperative and postoperative pain may also develop. These complications are frequently associated with significant morbidity and discomfort. In this review, we summarize the evidence from previous clinical studies regarding the optimal surgical margin for skin cancer and the methods for diminishing the complications associated with dermatologic surgery.

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Outcomes in intermediate-risk squamous cell carcinomas treated with Mohs micrographic surgery compared with wide local excision

Cited by 28 publications

References 21 publications

Identifying squamous cell carcinoma and cytokeratin-derived amyloid with pan-cytokeratin AE1/AE3 during Mohs micrographic surgery

Identifying squamous cell carcinoma and cytokeratin-derived amyloid with pan-cytokeratin AE1/AE3 during Mohs micrographic surgery

Post‐burn scar malignancy: 5‐year management review and experience

Evidence from Clinical Studies Related to Dermatologic Surgeries for Skin Cancer

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