Outcomes associated with early post-traumatic osteoarthritis and other negative health consequences 3–10 years following knee joint injury in youth sport

Whittaker, Jackie L.; Woodhouse, Linda J.; Nettel-Aguirre, Alberto; Emery, Carolyn A.

doi:10.1016/j.joca.2015.02.021

Cited by 159 publications

(144 citation statements)

References 52 publications

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“…Individuals with ACL injury are at high risk of poor longterm outcomes (eg, osteoarthritis, [18][19][20] knee pain, 21 diminished quality of life [21][22][23] ), and early symptoms predict more severe knee pain and symptoms 6 years after an ACL injury. 24 Furthermore, preoperative knee and body pain are important predictors of postsurgical outcomes 1 or 2 years after an ACL reconstruction.…”

mentioning

confidence: 99%

Posttraumatic Bone Marrow Lesion Volume and Knee Pain Within 4 Weeks After Anterior Cruciate Ligament Injury

Driban

Lohmander

Frobell

2017

Journal of Athletic Training

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Context: After an anterior cruciate ligament (ACL) injury, a majority of patients have a traumatic bone marrow lesion (BML, or bone bruise). The clinical relevance of posttraumatic lesions remains unclear.Objective: To explore the cross-sectional associations between traumatic BML volume and self-reported knee pain and symptoms among individuals within 4 weeks of ACL injury.Design: Cross-sectional exploratory analysis of a randomized clinical trial.Setting: Orthopaedic departments at 2 hospitals in Sweden. Patients or Other Participants: As part of a randomized trial (knee anterior cruciate ligament nonoperative versus operative treatment [KANON] study), 121 young active adults (74% men, age ¼ 26 6 5 years, height ¼ 1.8 6 0.1 m, weight ¼ 76 6 13 kg) with an ACL tear were studied.Main Outcome Measure(s): The BML volume in the proximal tibia and distal femur was segmented using magnetic resonance images obtained within 4 weeks of injury. A radiologist evaluated the presence of depression fractures on the images. Pain and symptoms of the injured knee (Knee Injury and Osteoarthritis Outcome Score [KOOS] pain and symptoms subscales) were obtained the same day as imaging. We used linear regression models to assess the associations.Results: Most knees had at least 1 BML (96%), and the majority (57%) had a depression fracture. Whole-knee BML volume was not related to knee pain for the entire cohort (b ¼ À0.09, P ¼ .25). Among those without a depression fracture, larger whole-knee BML volume was associated with increased knee pain (b ¼ -0.46, P ¼ .02), whereas no association was found for those with a depression fracture (b ¼ 0.0, P ¼ .96). Larger medial (b ¼ -0.48, P ¼ .02) but not lateral (b ¼ -0.03, P ¼ .77) tibiofemoral BML volume was associated with greater pain. We found no association between BML volume and knee symptoms.Conclusions: We confirmed the absence of relationships between whole-knee BML volume and pain and symptoms within 4 weeks of ACL injury. Our findings extend previous reports in identifying weak associations between larger BML volume in the medial compartment and greater pain and between BML volume and greater pain among those without a depression fracture.Key Words: knee injuries, magnetic resonance imaging, sprains, trauma, patient-reported outcomes Key PointsWithin 4 weeks of anterior cruciate ligament injury, total-knee bone marrow lesion volume and self-reported pain and symptoms were not associated. More pain was weakly related to greater medial compartment and greater total-knee bone marrow lesion volume and to greater bone marrow lesion volume among participants without a depression fracture.

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mentioning

confidence: 99%

Posttraumatic Bone Marrow Lesion Volume and Knee Pain Within 4 Weeks After Anterior Cruciate Ligament Injury

Driban

Lohmander

Frobell

2017

Journal of Athletic Training

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“…14 For example, knee injury sustained in youth increases the risk of developing early onset post-traumatic osteoarthritis that can negatively impact quality of life, physical function during sport and recreational activities, and increase pain and symptoms. 15,16 The most common injury types in the youth population are sprains and strains. 1,3,8,14,17 Lower extremity injuries, specifically ankle and knee injuries, are prevalent in this population and account for up to 70% of all time loss injuries in youth.…”

Section: Sport and Recreational Injury In Adolescentsmentioning

confidence: 99%

“…(2015) 16 compared outcomes between 50 participants who had sustained a knee injury 3 to 10 years previously during youth sport with 50 healthy controls matched on age, sex, and sport. 45 Although results emerging from the above cross-sectional study are important, the methodology was poorly written, as it did not describe balance protocols in detail.…”

Section: Previous Injury and Balance Outcomesmentioning

confidence: 99%

“…Whittaker et al (2015) selected participants who were injured while playing a sport during their youth; however, the mean age at the time of data collection was 22 years, and assessments were completed 3-10 years after injury. None of the studies objectively measured balance ability pre-injury, and instead made comparisons to either the uninjured limb 41,45 or a group of uninjured participants.…”

Section: Previous Injury and Balance Outcomesmentioning

confidence: 99%

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The Influence of Previous Injury History on Health and Fitness Outcomes in Junior High School Students

Berg

2017

Br J Sports Med

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Objective: To assess the influence of previous sport and recreational injury on body composition, cardiorespiratory fitness, musculoskeletal strength, and dynamic balance in junior high school students (ages 11-16).Methods: Cross-sectional study design. Participants included 1,039 students from six junior high schools in Calgary, Alberta, Canada. Demographics, injury history, and sport participation over the previous 12 months were collected using a questionnaire. Outcome measures included body mass index (BMI), waist circumference, predicted VO 2 max, vertical jump, eyes closed dynamic balance, and star excursion balance test reach distances.Results: Previously injured participants had significantly higher BMI and left foot balance times compared to uninjured participants. Exploratory analysis results suggest that those who sustained two injuries had a significantly increased BMI and waist circumference compared to those who sustained no injuries. Conclusions:Participants with a history of injury demonstrated more unhealthy body composition, but better left foot dynamic balance compared to uninjured participants.iii Acknowledgements

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“…cardiovascular disease prevention [1][2], brain ischemic tolerance improvement [3][4], and more. However, physical impairment due to excessive exercise had been reported as well, such as muscle cramps [5], osteoarthritis [6], rhabdomyolysis [7,8], serious renal injuries [9] and sudden cardiac death [10]. Hence, benefit of exercise to illness prevention has long been an issue of great interest in physiology and related disciplines, but in the absence of an easy-to-use, but high performance, tool for physiological monitoring, say, heart rate variability during exercise.…”

Section: Introductionmentioning

confidence: 99%

A Tail-Worn Sensor-Equipped Heart Rate Measurement Apparatus for Ischemic Stroke Prevention

Chen¹,

Chang²

2018

Neuropsychiatry

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Objective:This paper presents a tail-worn sensor-equipped heart rate measurement apparatus to quantify the effect of exercise preconditioning on the physical disability of rats due to ischemic stroke. So far, physiological measurements in the literature are mostly conducted in an invasive manner, meaning that sensor implant surgery is a necessity, and result in the risk of infection and the problem of interrupted data capture. Nonetheless, most existing noninvasive physiological measurement apparatus are designed for animals at rest, not on the move. For this sake, this heart rate measurement apparatus was developed as an easy-touse, but high performance, non-invasive tool for long-term physiological monitoring on rats, particularly in the running state. Methods:The presented non-invasive measurement apparatus comprises a front-end PPG sensor array and a back-end digital signal processor. A PPG signal was chosen for back-end signal extraction, using an adaptive filer and Hilbert-Huang Transform (HHT). This work was experimentally validated by the heart rate variability due to the epinephrine administration to rats in the conscious and unconscious states, and a heart rate monitoring in the running state was performed at the end of this work. Results:Rats under test were equally divided into two groups for comparison purposes, one as the control group and the other as the exercise group, and each member in the latter needs to take a 3-week physical training program as a preconditioning. In weeks 1-3, the exercise (control) group members demonstrated an average pre-exercise heart rate of 358.31 (356.89), 328.21 (360.1) and 312.91 (361.68) BPM, respectively. The exercise group members clearly have a much slower preexercise average heart rate than the control group in weeks 2-3, indicating a negative correlation between the heart rate and the slide angle result of an inclined plane test. Conclusions:This paper presents a novel physiological measurement apparatus as a non-invasive alternative to a typical inclined plane test for quantifying the benefit of exercise preconditioning to ischemic stroke prevention. Featuring low physical confinement on animals and long-term monitoring, it was experimentally validated herein as an easy-to-use, but high performance, tool, and is expected to be employed in futuristic clinical research.

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Outcomes associated with early post-traumatic osteoarthritis and other negative health consequences 3–10 years following knee joint injury in youth sport

Abstract: This study provides preliminary evidence that youth/young adults following sport-related knee injury report more symptoms and poorer function, and are at greater risk of being overweight/obese 3-10 years post-injury compared to matched uninjured controls.

Cited by 159 publications

References 52 publications

Posttraumatic Bone Marrow Lesion Volume and Knee Pain Within 4 Weeks After Anterior Cruciate Ligament Injury

Posttraumatic Bone Marrow Lesion Volume and Knee Pain Within 4 Weeks After Anterior Cruciate Ligament Injury

The Influence of Previous Injury History on Health and Fitness Outcomes in Junior High School Students

A Tail-Worn Sensor-Equipped Heart Rate Measurement Apparatus for Ischemic Stroke Prevention

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