Outcomes after corneal crosslinking treatment in paediatric patients with keratoconus

Abstract

To determine the e cacy and safety of accelerated corneal crosslinking in children with keratoconus. MethodsTwo hundred twenty-nine eyes of 146 patients aged 16 years and younger with keratoconus were included in this study. The best corrected visual acuity (BCVA), spherical and cylindrical values, keratometric values (K1-K2), steepest keratometric value (Kmax), and thinnest corneal thickness (TCT) of the patients were recorded pre-operatively and post-operatively at 1, 3, 6, and 12 months. Ocular and systemic diseases associated with keratoconus were also recorded. ResultsThe results showed stabilization of refractive BCVA in the rst postoperative month, with a slight improvement over time. The Keratometric values (K1 and K2) and Kmax remained stable throughout the follow-up period. The minimum central corneal thickness initially decreased but stabilized 12 months after crosslinking. No complications, such as corneal opacity, non-healing epithelial defects, or corneal infections, were observed during the follow-up. Allergic conjunctivitis (30.8%), congenital cataracts (1.36%), nystagmus (0.68%) and blepharoptosis (0.68%), were the most common ocular co-morbidities. ConclusionThe paediatric age group is at high risk due to the rapid and aggressive nature of the disease. According to the results of our study, corneal crosslinking treatment in childhood limited the progression of keratoconus and at the same time provided a slight increase in visual acuity.

Corneal Cross-linking in Pediatric Populations: Systematic Review and Future Perspectives

“…The follow-up time of the selected studies ranged from 12 months to 10 years. Three studies had a 12-month follow-up,27,28,35 one study had a 16-month follow-up,32 three studies had a 24-month follow-up,25,26,33 one study had a 36-month follow-up,31 one study had a 56-month follow-up,29 one study had a 60-month follow-up,30 and one study had a 120-month follow-up 34…”

“…In protocols with prolonged irradiation, Cankaya et al35 evaluated 34 eyes (10 to 16 years) using riboflavin with dextran for 15 minutes. The study reported a significant reduction in Kmax from 54.40 ± 5.96 to 53.98 ± 5.86 D, with 100% stabilization at 12 months.…”

“…Eleven studies25–35 were eligible for this review. The follow-up time of the selected studies ranged from 12 months to 10 years.…”

Corneal Cross-linking in Pediatric Populations: Systematic Review and Future Perspectives

“…The follow-up time of the selected studies ranged from 12 months to 10 years. Three studies had a 12-month follow-up,27,28,35 one study had a 16-month follow-up,32 three studies had a 24-month follow-up,25,26,33 one study had a 36-month follow-up,31 one study had a 56-month follow-up,29 one study had a 60-month follow-up,30 and one study had a 120-month follow-up 34…”

“…In protocols with prolonged irradiation, Cankaya et al35 evaluated 34 eyes (10 to 16 years) using riboflavin with dextran for 15 minutes. The study reported a significant reduction in Kmax from 54.40 ± 5.96 to 53.98 ± 5.86 D, with 100% stabilization at 12 months.…”

“…Eleven studies25–35 were eligible for this review. The follow-up time of the selected studies ranged from 12 months to 10 years.…”

Corneal Cross-linking in Pediatric Populations: Systematic Review and Future Perspectives

“…The follow-up time of the selected studies ranged from 12 months to 10 years. Three studies had a 12-month follow-up,27,28,35 one study had a 16-month follow-up,32 three studies had a 24-month follow-up,25,26,33 one study had a 36-month follow-up,31 one study had a 56-month follow-up,29 one study had a 60-month follow-up,30 and one study had a 120-month follow-up 34…”

“…In protocols with prolonged irradiation, Cankaya et al35 evaluated 34 eyes (10 to 16 years) using riboflavin with dextran for 15 minutes. The study reported a significant reduction in Kmax from 54.40 ± 5.96 to 53.98 ± 5.86 D, with 100% stabilization at 12 months.…”

“…Eleven studies25–35 were eligible for this review. The follow-up time of the selected studies ranged from 12 months to 10 years.…”

Corneal Cross-linking in Pediatric Populations: Systematic Review and Future Perspectives

“…The follow-up time of the selected studies ranged from 12 months to 10 years. Three studies had a 12-month follow-up,27,28,35 one study had a 16-month follow-up,32 three studies had a 24-month follow-up,25,26,33 one study had a 36-month follow-up,31 one study had a 56-month follow-up,29 one study had a 60-month follow-up,30 and one study had a 120-month follow-up 34…”

“…In protocols with prolonged irradiation, Cankaya et al35 evaluated 34 eyes (10 to 16 years) using riboflavin with dextran for 15 minutes. The study reported a significant reduction in Kmax from 54.40 ± 5.96 to 53.98 ± 5.86 D, with 100% stabilization at 12 months.…”

“…Eleven studies25–35 were eligible for this review. The follow-up time of the selected studies ranged from 12 months to 10 years.…”