Outcome of Surgical Management of Bisphosphonate-Related Osteonecrosis of the Jaws: Review of 33 Surgical Cases

Stanton, David C.; Balasanian, Edward

doi:10.1016/j.joms.2008.12.057

Cited by 112 publications

(78 citation statements)

References 10 publications

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“…Approximately half of those treated with local debridement do not show clinical improvement. Stanton and Balasanian 23 retrospectively analyzed 30 patients affected Note: A relative risk lower than 1 indicates a protective effect against a negative outcome, whereas a relative risk higher than 1 indicates a tendency toward a negative outcome. The relative risk for subjects who underwent resective surgery (reference group) is 0.7 (confidence interval, 0.4 to 0.8; P ϭ .002).…”

Section: Discussionmentioning

confidence: 99%

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Resective Surgical Approach Shows a High Performance in the Management of Advanced Cases of Bisphosphonate-Related Osteonecrosis of the Jaws: A Retrospective Survey of 347 Cases

Graziani

Vescovi

Campisi

et al. 2012

Journal of Oral and Maxillofacial Surgery

115

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Purpose:The aim of this study was to evaluate the results of the surgical treatment of bisphosphonaterelated osteonecrosis of the jaw (BRONJ) in a large cohort. Materials and Methods: A retrospective cohort multicenter study was designed. Patients were enrolled if they were diagnosed with BRONJ and received operative treatment. Data on demographic, health status, perioperative, and surgical factors were collected retrospectively. The primary outcome variable was a change in BRONJ staging (improvement, worsening, or no change). Interventions were grouped by local debridement and resective surgery. Data were collected for other variables as cofactors. Univariate analysis and logistic regressions were then performed. Results: Of the 347 BRONJ-affected subjects, 59% showed improvement, 30% showed no change, and 11% showed worsening. Improvement was observed in 49% of cases treated with local debridement and 68% of cases treated with resective surgery. Multivariate analysis indicated that maxillary location, resective surgery, and no additional corticosteroid treatment were associated with a positive outcome. Conclusions: Surgical treatment of BRONJ appeared to be more effective when resective procedures were performed. Nonetheless, other factors, such as the absence of symptoms and the types of drug administration, should be taken into account before clinical decisions are made.

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Section: Discussionmentioning

confidence: 99%

“…From an epidemiologic point of view, lesions are more frequently associated with the mandible. 23,[25][26][27] This is probably due to the minor thickness of the mucosa and its lower vascularization compared with that of the maxilla. Indeed, an analysis of the present data indicated that maxillary lesions have a better prognosis.…”

Section: Discussionmentioning

confidence: 99%

Resective Surgical Approach Shows a High Performance in the Management of Advanced Cases of Bisphosphonate-Related Osteonecrosis of the Jaws: A Retrospective Survey of 347 Cases

Graziani

Vescovi

Campisi

et al. 2012

Journal of Oral and Maxillofacial Surgery

115

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show abstract

“…Stage 3 cases are commonly treated by surgery, such as sequestrectomy and resection [4,8]. However, several studies have suggested that the success rate of surgical treatment for BRONJ is only 60-86% [16][17][18][19]. Thus, many BRONJ patients do not receive active treatment.…”

Section: Introductionmentioning

confidence: 99%

Multipotent mesenchymal stromal cell sheet therapy for bisphosphonate-related osteonecrosis of the jaw in a rat model

et al. 2016

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Bisphosphonates are frequently used to treat osteoporosis, bone metastasis of various cancers, and other diseases. However, bisphosphonate related-osteonecrosis of the jaw (BRONJ) is an intractable disease because it often recurs after surgery or is exacerbated following conservative treatment. Therefore, an alternative approach for treating BRONJ is needed. In this study, we developed a bone marrow-derived multipotent mesenchymal stromal cell (MSC) sheet to treat BRONJ and investigated the effect of MSC sheet transplantation in a rat model of BRONJ-like disease. The MSC sheet transplantation group showed wound healing in most cases, while only minimal healing was observed in the control group and MSC intravenous injection group. Our results suggest that the MSC sheet is a promising alternative approach for the treatment of BRONJ.

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“…Literatürde bazı yazarlar uzun süreli antibiyotik ilaç ve antimikrobiyal ağız gargaraları gibi konservatif tedavi seçeneklerini önermektedirler 22,23 ; fakat konservatif yaklaşım literatürde geçen bu vakaların üçte ikisinden daha azında ancak geçici bir iyileşme sağlayabilmektedir [23][24][25] . Buna karşın literatürde lezyonun patolojik kırık, ekstraoral fistül oluşumu gibi daha ileri komplikasyonlara sebep olmadan cerrahi olarak uzaklaştırılmasının, olguların yaklaşık %80'inin tedavisinde başarılı olduğu bildirilmektedir [26][27][28][29][30] . AAOMS'un 2014 yılında yayınlamış olduğu görüş bildirgesinde, hastanın BP cinsinin ve kullanım süresinin İÇKON oluşmasına olan etkisi bildirilmiştir 1 .…”

Section: Discussionunclassified

Oral bisphosphonate induced osteonecrosis of the jaw causing pathological mandibular fracture: literature review and a case report

Duygu¹,

Ülker²,

Cabbar³

et al. 2016

Yeditepe J Dent

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Outcome of Surgical Management of Bisphosphonate-Related Osteonecrosis of the Jaws: Review of 33 Surgical Cases

Cited by 112 publications

References 10 publications

Resective Surgical Approach Shows a High Performance in the Management of Advanced Cases of Bisphosphonate-Related Osteonecrosis of the Jaws: A Retrospective Survey of 347 Cases

Resective Surgical Approach Shows a High Performance in the Management of Advanced Cases of Bisphosphonate-Related Osteonecrosis of the Jaws: A Retrospective Survey of 347 Cases

Multipotent mesenchymal stromal cell sheet therapy for bisphosphonate-related osteonecrosis of the jaw in a rat model

Oral bisphosphonate induced osteonecrosis of the jaw causing pathological mandibular fracture: literature review and a case report

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