Outcome of Septic Shock in the Elderly Following the Implementation of the Sepsis Bundle: A Propensity-Adjusted Analysis

Akinnusi, Morohunfolu E.; Alsawalha, Leith N.; Pineda, Lilibeth A.

doi:10.1378/chest.132.4_meetingabstracts.494

Cited by 4 publications

(1 citation statement)

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“…13 Multiple studies have repeatedly demonstrated that ED-based sepsis protocols improve outcomes. 4,9,14,21,[28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44] Definitive recognition and rapid treatment of sepsis has been shown to improve patient outcomes. Early goal-directed therapy has been shown to decrease absolute mortality by 16% 31 and compliance with a sepsis protocol has been shown to improve patient survival.…”

Section: Introductionmentioning

confidence: 99%

Sepsis Bundles and Compliance With Clinical Guidelines

Stoneking

Denninghoff

DeLuca

et al. 2011

J Intensive Care Med

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Realizing the vast medical benefits of validated protocols, recommendations and practice guidelines requires acceptance and implementation by frontline care providers. Knowledge translation is the science of accelerating the transfer of knowledge to practice by understanding and creatively addressing the barriers that prevent adoption of new professional standards. In an attempt to improve patient care and reduce mortality, the Surviving Sepsis Campaign and The Institute for Healthcare Improvement created the resuscitation and management bundles for patients with severe sepsis and septic shock. These bundles have been accepted as best practice by many clinicians since multiple clinical trials have produced similar positive results when they were implemented. However, transferring these research outcomes-based guidelines to the clinical practice arena has been associated with poor compliance due to important barriers to implementation. Delays in the adoption of sepsis bundles are not surprising since the time from validation to implementation of a new clinical practice is typically 17 years. Using sepsis bundles as a model, this article explores why guidelines are important, examines physician adherence to protocols, and reviews the literature on strategies to improve clinical compliance and enhance knowledge translation.

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Section: Introductionmentioning

confidence: 99%

Sepsis Bundles and Compliance With Clinical Guidelines

Stoneking

Denninghoff

DeLuca

et al. 2011

J Intensive Care Med

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show abstract

Sepsis Response Team

Rivers

Amponsah²,

Coba³

2010

Textbook of Rapid Response Systems

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Early goal-directed therapy in severe sepsis and septic shock: a contemporary review of the literature

Rivers

Coba

Whitmill

2008

Current Opinion in Anaesthesiology

155

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Early goal-directed therapy modulates systemic inflammation and results in significant reductions in morbidity, mortality, and healthcare resource consumption. Early goal-directed therapy has been externally validated and is generalizable across multiple healthcare settings. Because of these robust findings, further emphasis should be placed on overcoming logistical, institutional, and professional barriers to implementation which can save the life of one of every six patients presenting with severe sepsis and septic shock.

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Outcome of Septic Shock in the Elderly Following the Implementation of the Sepsis Bundle: A Propensity-Adjusted Analysis

Cited by 4 publications

References 0 publications

Sepsis Bundles and Compliance With Clinical Guidelines

Sepsis Bundles and Compliance With Clinical Guidelines

Sepsis Response Team

Early goal-directed therapy in severe sepsis and septic shock: a contemporary review of the literature

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