Outcome of paediatric convulsive status epilepticus: a systematic review

Raspall-Chaure, Miquel; Chin, Richard; Neville, Brian; Scott, Rod C.

doi:10.1016/s1474-4422(06)70546-4

Cited by 258 publications

(275 citation statements)

References 98 publications

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“…The risk of subsequent epilepsy after SE is high in both children and adults, with highest onset risk during the first year of follow‐up 4. In pediatric patients, this risk ranges from 5% to 36% 6, 26, 27, 28, 29.…”

Section: Long‐term Outcomes Of Sementioning

confidence: 99%

“…Status epilepticus (SE), especially refractory SE (RSE), is a life‐threatening condition often requiring intensive care 1, 2, 3, 4. Long‐term sequelae may include neurological, cognitive, and behavioral impairments and decline in quality of life (QoL),4, 5 and impose heavy burdens on the patient, the caregivers, and the healthcare system.…”

Section: Introductionmentioning

confidence: 99%

“…Long‐term sequelae may include neurological, cognitive, and behavioral impairments and decline in quality of life (QoL),4, 5 and impose heavy burdens on the patient, the caregivers, and the healthcare system. Outcomes are influenced by type of epilepsy, type of SE, etiology, SE duration, and patient's age 4. This review aims to provide an overview of long‐term outcomes in patients with SE.…”

Section: Introductionmentioning

confidence: 99%

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Long‐term outcomes of status epilepticus: A critical assessment

et al. 2018

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SummaryWe reviewed 37 studies reporting long‐term outcomes after a status epilepticus (SE) episode in pediatric and adult populations. Study design, length of follow‐up, outcome measures, domains investigated (mortality, SE recurrence, subsequent epilepsy, cognitive outcome, functional outcome, or quality of life), and predictors of long‐term outcomes are summarized. Despite heterogeneity in the design of prior studies, overall risk of poor long‐term outcome after SE is high in both children and adults. Etiology is the main determinant of outcome, and the effect of age or SE duration is often difficult to distinguish from the underlying cause. The effect of the treatment on long‐term outcome after SE is still unknown.

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Section: Long‐term Outcomes Of Sementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Long‐term outcomes of status epilepticus: A critical assessment

et al. 2018

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“…Furthermore, Gauthey et al describe a more severe phenotype with children with fragile X presenting with status epilepticus (seizures lasting > 30 min) at their initial seizure with recurrent prolonged seizures on follow-up (Gauthey et al, 2010). Status epilepticus in the developing brain is known to significantly increase the risk of epilepsy, hippocampal sclerosis and further behavioural and cognitive deficits in later life in human and animals studies (Raspall-Chaure et al, 2006;Dunleavy et al, 2010). There is a large amount of data from animal studies (described above) to support a role for disruption of normal GABAergic function in seizure generation in FXS.…”

Section: Clinical Evidence Of a Role For Gabaergic Involvement In Epimentioning

confidence: 99%

GABAergic Dysfunction in Autism and Epilepsy

Genovesi¹,

Provenzano²,

Dunleavy³

et al. 2011

Autism - A Neurodevelopmental Journey From Genes to Behaviour

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“…SE affects people of all ages, though it is more common and causes greater morbidity and mortality in infants. [1][2][3][4][5] Status epilepticus (SE) is an epileptic seizure of greater than five minutes or more than one seizure within a fiveminute period without the regaining the conciousness in between the episodes. 6 The incidence of childhood convulsive SE (CSE) in developed countries is approximately 20/100,000/year but it varies according to socioeconomic and ethnic characteristics of the population.…”

Section: Introductionmentioning

confidence: 99%

A study of the etiology and short term outcome of status epilepticus in children

Selvan

Murthy

Saravanan

et al. 2017

Int J Contemp Pediatr

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Background: Convulsive status epilepticus is the most common childhood medical neurological emergency, and is associated with significant morbidity and mortality. Most data for this disorder are from mainly adult populations and might not be relevant to childhood. This study was done to obtain a uniquely paediatric perspective. The objective of the study was to the etiology and short term outcome of patients admitted with status epilepticus between the age group 1 month to 12 years at a medical college hospital.Methods: Study design: Prospective descriptive study. Study Place: Department of Paediatrics, SIMS and RC, Bangalore, India. Study population: All children in the age group of 1 month to 12 years admitted with status epilepticus. Sample size:66. Study period: From January 2016 to December 2016.Results: Prevalence of status epilepticus among children admitted in this study was 8.7%. Most common age was found to be 1-3 years (54.5%). Preponderance of male (51.5%) over female (48.5%) was observed. The two most common etiology observed was Atypical febrile seizures (33.3%) and meningitis (22.7%). 57.5% children presented as first episode of seizure and duration of seizure was less than 2 hours in 65.1%.In our study, short term mortality rate was found to be 3% and morbidity was found to be 9% and meningitis was responsible for all the deaths. The mortality and morbidity in the form of neurodeficits were observed between the age group of 1 month to 3 years. Based on the duration of seizure lasting more than 8 hours, two third had mortality and one third had morbidity.Conclusions: Status epilepticus is a severe life threatening emergency with substantial morbidity and mortality. Major causes were due to atypical febrile seizure and meningitis. Patients with younger age, male sex and seizures lasting longer duration had higher mortality and morbidity, predicting the poor outcome.

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Outcome of paediatric convulsive status epilepticus: a systematic review

Cited by 258 publications

References 98 publications

Long‐term outcomes of status epilepticus: A critical assessment

Long‐term outcomes of status epilepticus: A critical assessment

GABAergic Dysfunction in Autism and Epilepsy

A study of the etiology and short term outcome of status epilepticus in children

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