Outcome of Infants With Birth Weights Less Than 1000 g With Respiratory Distress Syndrome Treated With High-Frequency Ventilation and Surfactant Replacement Therapy

Effect of vibration on auditory organ systems in low‐birth weight infants treated with high‐frequency oscillatory ventilation: 5 year outcome

“…Patel et al 10 have reported that there were no differences in the incidence of significant hearing impairment between the HFOV group (3.7%) and the CMV group (2.4%).…”

High-frequency oscillation versus conventional ventilation following surfactant administration and partial liquid ventilation

“…Others have shown that surfactant used during HFO produces similar physiologic and similar or improved pathologic outcomes as surfactant during CV. [25][26][27] Likewise, HFO using PLV produces similar to improved physiologic outcomes when compared to HFO alone. 22 Finally, surfactant treatment followed by PLV produces better physiologic and pathologic outcomes than conventional ventilation with surfactant alone.…”

“…18 A number of studies suggest that surfactant used in conjunction with HFO is as effective as when used during CV, and may further decrease lung injury. [25][26][27] There is little information about the interaction between PLV and surfactant during high-frequency ventilation.…”

“…While recommendations exist for administration of surfactant during conventional ventilation, the optimum technique for surfactant delivery and ventilator management during HFO has not been clearly defined. Tamura 28 and Patel 25 both described improved outcomes using combined surfactant and HFO treatment in neonates, but neither provided specific management details. Studies in preterm lambs and premature baboons suggested that the early use of HFO alone might reduce or prevent the formation of hyaline membranes seen in respiratory distress syndrome.…”

“…Though surfactant administration using this technique has not been studied as definitively, good clinical outcomes in patients with RDS have been reported. 25,33 We chose this technique for study to best approximate the clinical situation, but did not aggressively increase MAP until 30 min after perflubron administration. In spite of our initial selection of a MAP at least 2 cm H 2 O higher than that used during conventional ventilation, the HFO animals in this study were still at lower than optimal lung volumes when surfactant was given.…”