Outcome of Hospital Admissions in HIV-infected Children at the Korle Bu Teaching Hospital, Accra, Ghana

Kwara, Awewura; Shah, Dhara; Renner, LA

doi:10.4314/wajm.v29i6.68264

Cited by 5 publications

(5 citation statements)

References 9 publications

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“…The average age of children in our study at admission was high; 5 years 7 months (66.11 months) in group A and 4 years 1 month (49 months) in group B. Kwara et al [6] in Ghana and Ugochukwu [7] in Nigeria reported similar mean age (4.5 years and 4.78 years). The majority of children in group A (84.74%) and more than one third of children in group B (29.28%) were symptomatic.…”

Section: Discussionsupporting

confidence: 47%

HIV Morbidity and Mortality in the Pediatric Population of Côte d’Ivoire

ME¹

2014

Clinics Mother Child Health

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Section: Discussionsupporting

confidence: 47%

HIV Morbidity and Mortality in the Pediatric Population of Côte d’Ivoire

ME¹

2014

Clinics Mother Child Health

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“…Early deaths in HIV-infected children are often a result of overwhelming infections in a setting of severe immunodeficiency and malnutrition [27,28]. Due to the rapid progression of disease and the delays in diagnosis, many infants enroll for medical care when infection, malnutrition and severe immunodeficiency have set in.…”

Section: Discussionmentioning

confidence: 99%

Virologic, immunologic and clinical response of infants to antiretroviral therapy in Kampala, Uganda

et al. 2013

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BackgroundAntiretroviral therapy (ART) is known to save lives. Among HIV-infected infants living in resource constrained settings, the short and long term benefits of ART are only partially known. This study was designed to determine the virologic, immunologic and clinical outcomes of antiretroviral therapy in a cohort of HIV-infected infants receiving care from an outpatient clinic in Kampala, Uganda.MethodsA prospective cohort of HIV-infected infants receiving treatment at the Baylor-Uganda clinic was analyzed. Patients were diagnosed, enrolled and followed up at the clinic. HIV viral load, CD4 cell counts and clinical progress were assessed during follow-up. Descriptive statistical analysis and logistic regression modeling to determine predictors of treatment success were conducted.ResultsOf 91 HIV-infected infants enrolled into the cohort, 53 (58.2%) infants were female; 43 (47.3%) were 6 months of age or younger, and 50 (55.6%) had advanced HIV/AIDS disease (Clinical stage 3 or 4). Eighty four infants started ART and 78 (92.9%) completed 6 months of treatments. Fifty six (71.8%) infants attained virologic suppression by month-6 of ART, and at month-12 of ART, the cumulative probability of attaining viral suppression was 83.1%. None of the baseline infant factors (age, sex, WHO stage, CD4 cell percent, weight for age, or height for age z-score) predicted treatment success. There was an increase in CD4 cells from a baseline mean of 23% to 30% at month-6 of treatment (p<0.001) and by month-24 of ART, the mean CD4 percent was 36%. A total of 7 patients died while on ART and another 7 experienced adverse events that were related to treatment.ConclusionOur results show that, even among very young patients from resource constrained settings, ART dramatically suppresses HIV replication, allows immune recovery and clinical improvement, and is safe. However, baseline characteristics do not predict recovery in this age group.

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“…Ghana, with an estimated population of nearly 24 million, has an estimated 336,000 people living with HIV [17] with considerable variations in various regions of the country [18]. Nearly all regions of Ghana are malaria-endemic with transmission being all year-round.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of clinically captured and confirmed malaria among HIV seropositve clinic attendants in five hospitals in Ghana

Adu-Gyasi

Fanello

Baiden

et al. 2013

Malar J

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BackgroundMalaria is associated with an increase in HIV viral load and a fall in CD4-cell count. Conversely, HIV infection disrupts the acquired immune responses to malaria and the efficacy of antimalarial drugs. This study was carried out in five Ghanaian hospitals to estimate the prevalence of clinically confirmed malaria among HIV patients by evaluating their hospital records.MethodsThis retrospective descriptive cross sectional study reviewed and collected data on malaria, using Case Record Forms from HIV patients’ folders in five hospitals in Ghana.ResultsThere were 933 patients records made up of 272 (29.2%) males and 661 (70.8%) females. Majority of the patients were aged between 21–40 (63.6%) years and the rest were between the ages 1–20 (2.8%) years, 41–60 (31.6%) years and 61–80 (2.1%) years of age.A total of 38.1% (355/933) of the patients were clinically suspected of having clinical malaria. Of these 339 (95.5%) were referred to the laboratory for confirmation of the diagnosis of malaria. Only 4.4% (15/339) of patients tested were confirmed as cases of malaria among the patients that were clinically suspected of having malaria and subsequently confirmed. Fever, was not significantly associated with a confirmed diagnosis of malaria [OR = 3.11, 95% CI: (0.63, 15.37), P = 0.142].ConclusionsThere was a 4.4% prevalence of confirmed malaria and 38.1% of presumptively diagnosed malaria from the case records of HIV patients from the selected hospitals in Ghana.

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Outcome of Hospital Admissions in HIV-infected Children at the Korle Bu Teaching Hospital, Accra, Ghana

Cited by 5 publications

References 9 publications

HIV Morbidity and Mortality in the Pediatric Population of Côte d’Ivoire

HIV Morbidity and Mortality in the Pediatric Population of Côte d’Ivoire

Virologic, immunologic and clinical response of infants to antiretroviral therapy in Kampala, Uganda

Prevalence of clinically captured and confirmed malaria among HIV seropositve clinic attendants in five hospitals in Ghana

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