Outcome of fetal echocardiography: A 17 year single‐institution experience in Japan

Abstract

Prenatal diagnosis of CHD enables planned labor, prevents ductal shock, and reduces prostaglandin E1 side-effects and medical expenditure.

Unexpected neonatal death caused by interrupted aortic arch, an uncommon congenital great vessel malformation: An autopsy case report

“…If there are no collateral vessels, the ductus arteriosus acts as the only supplier of arterial blood to the abdominal organs in IAA patients. In these cases, closure of the ductus arteriosus leads to multiple organ dysfunction and shock, called ''ductal shock'' [8]. In the present case, the patient was alive for 21 days, consistent with previous papers reporting the median age at death to be 4-10 days [3,4,9], and suggesting that closure of the ductus arteriosus is often prolonged in these patients.…”

Intrauterine fetal demise after prenatal diagnosis of congenital heart disease: assessment of risk

“…Viewing the problem from the prenatal perspective, there are limited published data that documents the incidence of IUFD amongst a wide range of CHD. In fact, the risk for stillbirth in the fetus with CHD varies depending on the study population analyzed (see Table ) but has been noted to be as high as 25–37% …”

“…Previous publications have noted up to a 20% incidence of genetic and extra‐cardiac anomalies (ECA) in the fetus with CHD . The reported incidence of IUFD in select populations of CHD varies according to the reference sited but ranges anywhere from 1 to 38% . The risk for IUFD in the fetus with CHD has led some practitioners to advocate a scheduled delivery prior to full term to control the timing of delivery with the goal of optimizing the postnatal care of the baby.…”

“…1,5,13 The reported incidence of IUFD in select populations of CHD varies according to the reference sited but ranges anywhere from 1 to 38%. 5,6,[8][9][10][11][12][13] The risk for IUFD in the fetus with CHD has led some practitioners to advocate a scheduled delivery prior to full term to control the timing of delivery with the goal of optimizing the postnatal care of the baby. There have been several recent publications [14][15][16] demonstrating that earlier delivery in the fetus with CHD, even in the late preterm and early term period, results in worse neonatal outcomes.…”

Microdeletion and Microduplication Analysis of Chinese Conotruncal Defects Patients with Targeted Array Comparative Genomic Hybridization

“…Moreover, a duplication of 22q11.2 region can also lead to 22q11.2 microduplication syndrome which has features overlapping 22q11.2 deletion syndrome [6,7]. Recent evidence have suggested that infant mortality associated with CHDs has improved considerably over recent decades [8–10]. Increasing sensitivity of diagnosis means that early preparation can be made for termination, surgery therapy and psychology, with the potential to improve survival [11].…”